Sentences with phrase «of active sites by»

Not exact matches

And while its reach may not be broad, Reddit is clearly a substantial digital - media entity when measured by its sheer size: The site gets more than 200 million unique visitors every month, and typically has about 4 million logged - in users every day, looking at or commenting on one of the community's more than 8 billion active pages.

Those companies are part of a small pack that see active secondary market trading, both privately and facilitated by sites like SecondMarket and SharesPost.

Recognizing that the 43 - year - old club is beloved by many active members and neighbors, Carondelet looks forward to developing relationships with the community to explore ways the facility can continue to serve as a resource during the transition of ownership, site improvement and renovation, and long - term in ways compatible with school use.

Admittedly, the $ 104 million spent advertising in print and on newspaper websites in 2006 was still only 5 % of the amount spent on TV ads in that cycle, but some politicians and consultants swear by newspapers and their sites as a channel to reach the politically active — including those under 40, who tend to get their news online.

By the late 90s, when I was helping to put together a massive index of political websites for the now - defunct PoliticalInformation.com, Libertarian sites, independent or party - associated, were extremely active and seemed to outnumber sites associated with the more traditional political parties and their issues.

The distribution of nitrogen atoms after the dissociation allowed the identification of the «active sites» for this reaction, which are formed by the low - coordinated, top metal atoms of atomic steps.

To their surprise, the researchers found that the samples from the thermokarst sites had lower levels of colored dissolved organic matter than did reference sites, suggesting that the carbon in the deeper soils exposed by thermokarst failure is significantly different from the carbon draining from the topmost, active layer of the permafrost, the team reports in the Proceedings of the National Academy of Sciences.

PET employs the antiparticle of the electron, the positron, that is emitted by radioactive elements which can be attached to biologically active molecules that target specific sites of the body.

By targeting RNA or protein subunits that have multiple sites for inactivation, but that are inextricably linked, this method allows for killing or disabling the RNA or protein without requiring the inhibition of multiple pathways that might be used by the organism to remain active and viable (and thus, multiple drugs are not needed, as wellBy targeting RNA or protein subunits that have multiple sites for inactivation, but that are inextricably linked, this method allows for killing or disabling the RNA or protein without requiring the inhibition of multiple pathways that might be used by the organism to remain active and viable (and thus, multiple drugs are not needed, as wellby the organism to remain active and viable (and thus, multiple drugs are not needed, as well).

The idea is that the drug, being within the nano - hydrogels, is transported directly to cancer cells where it can be released without damaging other parts of the body, because hydrogels offer the possibility of dosing a myriad of active substances on the site desired and can be administered as dry or swollen hydrogels by different routes: oral, nasal, buccal, rectal, transdermal, vaginal, ocular and parental.

This sequence contains the active site of the enzyme produced by the DFR - B gene.

One surprising finding from the study co-led by Johns Hopkins, Ehret says, was that many of the new sites identified were near genes that are active in cells that line the inside of blood vessels, suggesting those cells are somehow involved directly in blood pressure control.

By comparing high - resolution structures of two complexes — one containing both a DUB and a pseudo-DUB, and two copies of an inactive DUB by itself — the team determined that KIAA0157 alters the shape of the BRCC36 active site, by swinging an amino acid into position to make the complex able to catalyze chemical reactionBy comparing high - resolution structures of two complexes — one containing both a DUB and a pseudo-DUB, and two copies of an inactive DUB by itself — the team determined that KIAA0157 alters the shape of the BRCC36 active site, by swinging an amino acid into position to make the complex able to catalyze chemical reactionby itself — the team determined that KIAA0157 alters the shape of the BRCC36 active site, by swinging an amino acid into position to make the complex able to catalyze chemical reactionby swinging an amino acid into position to make the complex able to catalyze chemical reactions.

This construct was used to introduce the corresponding human FOP mutation R206H and the constitutive active variant of the receptor Q207D by Site - Directed Mutagenesis (QuikChange, Stratagene) using the following primer pairs (with lower - case letters indicating the nucleotides changed relative to wild - type Acvr1 sequence): R206H - chAcvr1 - fwd, 5 ′ - GCAAAGAACAGTGGCTCaCCAGATCACGCTTGTGG - 3 ′ and R206H - chAcvr1 - rev, 5 ′ - CCACAAGCGTGATCTGGtGAGCCACTGTTCTTTGC - 3 ′; chAcvr1 - ca - Q207D - fwd, 5 ′ - GCAAAGAACAGTGGCTCGCgAcATCACGCTTGTGGAGTG - 3 ′ and chAcvr1 - ca - Q207D - rev, 5 ′ - CACTCCACAAGCGTGATgTcGCGAGCCACTGTTCTTTGC - 3 ′).

Interestingly, the dominant model for the mechanism by which a small molecule like a drug fits into the active site of a disease - promoting enzyme and modulates its activity is that of a «lock and key».

That PNNL research team, led by Dr. Wendy Shaw, predicted that many parts of the protein scaffold play critical roles in catalytic activity and efficiency instead of only the active site.

The team demonstrates in their new work the ability to transform hAgo1 into a «slicer» by changing key parts of the protein at and away from the active site.

The scientific interest in this problem is motivated by the unusual structure of the active site of the enzyme, which consists of an Fe7MoS9 ensemble.

Copy of technical paper by Research Director Paul Robinson on long - term groundwater contamination at two uranium mill tailings sites in New Mexico titled: GROUNDWATER RESTORATION LONG BEYOND CLOSURE AT THE HOMESTAKE - MILAN AND UNITED NUCLEAR - CHURCH ROCK URANIUM MILL TAILINGS PILES, NEW MEXICO, USA: FULL - SCALE PROGRAMS REQUIRING MORE THAN 20 YEARS OF ACTIVE TREATMENT (24k document) in: «Proceedings of Conference on Uranium Mining and Hydrogeology - II», Claudia Helling, eof technical paper by Research Director Paul Robinson on long - term groundwater contamination at two uranium mill tailings sites in New Mexico titled: GROUNDWATER RESTORATION LONG BEYOND CLOSURE AT THE HOMESTAKE - MILAN AND UNITED NUCLEAR - CHURCH ROCK URANIUM MILL TAILINGS PILES, NEW MEXICO, USA: FULL - SCALE PROGRAMS REQUIRING MORE THAN 20 YEARS OF ACTIVE TREATMENT (24k document) in: «Proceedings of Conference on Uranium Mining and Hydrogeology - II», Claudia Helling, eOF ACTIVE TREATMENT (24k document) in: «Proceedings of Conference on Uranium Mining and Hydrogeology - II», Claudia Helling, eof Conference on Uranium Mining and Hydrogeology - II», Claudia Helling, et.

The researchers knew they needed a catalyst that could not only support active and efficient chemical reactions, but one that could also provide a stable interface with the semiconductor, allow the charge generated by the absorption of light from the semiconductor to be efficiently transferred to the sites doing catalysis, and permit as much light as possible to pass through.

Along the trajectories, active site mutations occurred, followed by other mutations that helped optimize the positioning of the residues in the new active sites.

We provide experimental and computational evidence that conformational flexibility can assist the emergence and subsequent evolution of new active sites by improving substrate and transition - state binding, through the sampling of many potentially productive conformations.

«I wonder if communication between active sites separated by a few hundred nanometers is a general feature of heterogeneous catalysts.»

In addition, the high activity of Fe - N - C catalysts and the FeN4 active - site structure was predicted by computer modeling conducted at Los Alamos, as was the possible reaction pathway.

The strategy, which she developed a decade ago, minimizes the emergence of resistance by using structural biology and other tools to guide the design of chemicals that bind precisely to an active site on a protein.

It also transports cholesterol from extra-hepatic sites, including the arterial wall, to the liver for excretion via reverse cholesterol transport.77 Results from IER (60 - 85 % ER / alternate days) trials have thus far been inconsistent, with some reporting decreases 40, and others increases 37, 39, but with the majority showing no effects on HDL cholesterol levels.38, 42, 43, 45, 49, 51, 52Inconsistencies may have arisen due to the biphasic response of HDL documented by studies of ER induced weight - loss, whereby levels typically decrease during active weight - loss then either return to baseline or (less commonly) rise following attainment of weight stability.78 Complementary increases in HDL levels and particle size have been shown when endurance exercise have been combined with IER 42, 46, 47 however further discussion goes beyond the scope of this review.

Some dating sites will attempt to deceive visitors in regards to the number of active users by leaving inactive accounts showing.

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The members weren't that active on the site as was evident by the profiles created just around few days of their last login.

Don't be misled by other dating sites claiming to have millions of members - most of those are probably not active or fake.

The site also does a good job of letting members sort those results by singles who are the most active, newest, closest to them, and online now, as well as those with profile photos.

I'm still trying to be diligent by reaching out and sending questions to a couple of guys a week, but frankly the options are getting further and further away from what I'm looking for (the age range of matches eharmony provides now swings widely, anywhere from 18 to 55 — most of which haven't even been active on the site in over a month).

This site has thousands of active users and almost every profile is crosschecked by the site administration for authenticity.

If any Ukrainian woman is ignorant of the fact that her profile is active in any dating site, it is likely that her false profile is created by any fraud person.

Live members are members who registered and confirmed their registration on the date of the report and are still active on the site — have not deleted their profile or were not deleted by moderators.

Oasis Active is also one of the few truly free dating sites in Australia, although that does mean your information and photos can be used by the company unless you change certain settings.

We delete profiles of women who are active on PPL sites as these profiles most often are managed by substitutes and only set up to get a man to pay for false correspondence.

FriendsDateNetwork HIV singles database is powered by a recognized name in HIV dating sites which adds both a layer of protecting and a extensive marketing team which leads to a more active community.

They are trying to «encourage active participation» which means of course they want you to participate more in the site, by sending and reply to emails which is obviously going to cost you money.

By launching a dating site with a white label provider, partners are provided with a database of active members, so that their site is never empty.

The site goes above and beyond the duties of the average online dating site, by providing members an active news center and a magazine in which they can participate.

By actively participating in our dating site, you'll find one of the most active databases for singles online.

I was fooled by some members of the site and I reported their profiles but still they are active members.

Our rankings for the best UK dating sites are determined primarily by the number of active members at each dating site.

Still number 1 rank pretty much since the site started in Thailand and powered by cupid media the world's largest online dating network Cupid still has the most active profiles of any of the major 5 dating sites in Thailand.

I came up with this number by adding Plenty of Fish's 2 million active users with 2.5 million US paid subscribers, and then adding in an extra million singles for all of the other free dating sites that people use.

Community features can be a real bonus to an adult dating site, especially when they are actually used by an active community of members.

The investigation of popular online dating sites used by millions of Australians, including RSVP, eHarmony, Oasis Active and OkCupid, found.

Members can be as involved or laid - back as they want to, with options ranging from simply browsing the site and perhaps creating a personal hotlist of favorite members, to becoming extremely active and engaging in life - like virtual sex using the Connexion feature, where you can digitally and physically connect by video sexting models as you both pleasure yourselves, as well as sending sensations to each other using high - tech paired sex toys.