Sentences with phrase «of active sites for»

Nature of the active sites for carbon dioxide reduction on metal nanoparticles: suggestions for optimizing performance T. Cheng, Z. Wang, W. A. Goddard

Not exact matches

Chris Slowe, chief technology officer for the site, which is one of the most active hubs of Bitcoin enthusiasts, told Cheddar it was Coinbase's migration to a new platform that led to the Bitcoin ban in late March, but ongoing site changes at Reddit should allow it to accept crypto payments again.

Personalized pricing for virtually any product is already a fact of life on hyper - active shopping sites such as Safeway.com.

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For those who want to remain active while traveling, Ambrose does also have a 24 - hour fitness room on - site that includes a full range of high - quality exercise equipment: treadmills, ellipticals, bicycles and free weights.

As part of the agreement, a dedicated promotional channel for Australian companies will be created on youku.com, a Chinese video sharing site with 500 million active users.

James Breen, director of the St. Charles Park District, told the South Elgin Village Board this week that some of the proposed park property lies in a wetland, and most of the park sites are too small for active uses such as soccer and baseball.

Keryn is the founder and editor - in - chief of Walking on Travels, an award - winning site that gives hope to today's active parents who don't want to stop their lives; they simply bring their kids along for the ride.

Tools are not causes of social actions, but parts of socio - technical action, things that help us do some things, hinder others, and are integral to how we live, act, and see ourselves — this is also how I hope people will think of the role of social networking sites and other technologies in the popular uprisings in Tunisia and Egypt, not as causes, or as irrelevant, but as tools (for protesters, though sometimes also for security forces)-- in North Africa, even with a less than open internet, some of those involved in recent events certainly seemed to produce their own role as active citizens partially through the use of everyday tools and technologies.

By the late 90s, when I was helping to put together a massive index of political websites for the now - defunct PoliticalInformation.com, Libertarian sites, independent or party - associated, were extremely active and seemed to outnumber sites associated with the more traditional political parties and their issues.

The Ron Paul army was particularly active on The Caucus and The Trail before the wind finally went out of their sails, for instance, and these sites have also seen heated discussion among supporters and opponents of Obama, Clinton and McCain.

She also listed a growing market for second - hand devices and the increasing use of social media sites (active social media users) as contributing factors.

Remediation of legacy sites is a broad issue for industry and ExxonMobil is an active participant.

The distribution of nitrogen atoms after the dissociation allowed the identification of the «active sites» for this reaction, which are formed by the low - coordinated, top metal atoms of atomic steps.

Three positive, conserved electrostatic patches on the N - terminal domain of DnaB may also serve as a binding site for DNA and thereby guide the DNA to a DnaG active site.

«Breaking down metal oxide into tiny particles increases its surface area and exposes lots of ultra-small, interconnected grain boundaries that become active sites for the water - splitting catalytic reaction,» Cui said.

«It will be a permanent network of sites for these observations, including the active layer, the thawing layer,» Brown says.

In many diseases, however — for example of the central nervous system — it is of decisive importance to transport the active substance as efficiently as possible to the required target site.

Perhaps the most promising new addition to the online mental health scene is afterdeployment.org, a site for veterans and active servicemen and servicewomen who may be dealing with a host of problems, including post-traumatic stress disorder, anxiety and depression.

By targeting RNA or protein subunits that have multiple sites for inactivation, but that are inextricably linked, this method allows for killing or disabling the RNA or protein without requiring the inhibition of multiple pathways that might be used by the organism to remain active and viable (and thus, multiple drugs are not needed, as well).

«This TFLY motif comprises a significant part of the binding pocket that enables the enzyme to grapple the RNA template and guide it to the active site of the enzyme for catalysis,» Skordalakes said, «but it also facilitates the stable association of the protein with its RNA component thus forming a fully functional telomerase enzyme.»

This model structure of the catalytic portion of telomerase shows how the TFLY motif (green) is positioned at the entry of the pocket that guides the RNA template in the interior cavity of the telomerase ring and were the active site of the enzyme if located for catalysis.

Based on this work, a team of scientists from the University of Granada (Spain), the University of Uppsala (Sweden), the «Instituto de Quimica Fisica Rocasolano» (Madrid, Spain), the Georgia Institute of Technology (USA) and with data collected at the ESRF, the European Synchrotron, located in Grenoble (France), explored and tested these notions using resurrected Precambrian β - lactamases as scaffolds for the engineering of completely new active sites.

«Three - dimensional structural information derived from the data obtained at the ESRF was essential for the interpretation of the work, as it led to a high - resolution structure of the new active site and provided conclusive evidence of the role of protein re-organisation in the emergence of the new function» explains Jose A. Gavira, corresponding author, from the University of Granada.

But compared with most typical new moms, those suffering from postpartum depression are less active on the social media site, Munmun De Choudhury of Georgia Tech reported February 14 at the annual meeting of the American Association for the Advancement of Science.

Despite the substantial differences between these two classes of natural products, each is synthesized biologically under the control of exceptionally large, multifunctional proteins termed polyketide synthases (PKSs) and non-ribosomal peptide synthetases (NRPSs) that contain repeated, coordinated groups of active sites called modules, in which each module is responsible for catalysis of one complete cycle of polyketide or polypeptide chain elongation and associated functional group modifications.

To increase screening success, Zhou chose a probe that specifically binds to the Pin1 enzyme active site very tightly, an approach that is not commonly used for this kind of screen.

The antibodies EM - 4C04 and 1009 - 3B06 are specific for the active site of the HA molecule, whereas 70 - 1F02 binds to the stalk region.

Interestingly, the dominant model for the mechanism by which a small molecule like a drug fits into the active site of a disease - promoting enzyme and modulates its activity is that of a «lock and key».

Funds raised here will directly support the rebuilding of urgently needed infrastructure (e.g. rain water collectors) for the monkeys and will help ensure Cayo Santiago remains the active field site on which future scientific discoveries and the livelihood of the local community depend.

Researchers at the Moorea site have been active in developing the cyberinfrastructure for a sensor network that would provide real - time environmental data to enable better management of the reef ecosystem.

The implication: It is not just the active site that is important for determining the activity of a protein.

«This is the highest - resolution structure of a eukaryotic Argonaute to date, which allows for more in - depth analysis of important features like its active site,» says Joshua - Tor.

Chemists from the US Department of Energy's Brookhaven National Laboratory and their collaborators have definitively identified the active sites of a catalyst commonly used for making methanol from CO2.

PUM has a lower resistance rate and a smaller resistance target than Rif — just 2 to 4 positions where alterations that result in PUM - resistance (blue) vs. 27 positions where alterations result in Rif - resistance (red)-- due to functional constraints on alteration of the binding site for PUM in the RNA polymerase active center.

• Patients must have adequate coagulation (international normalized ratio (INR) or prothrombin time (PT), partial thromboplastin time (PTT) ≤ 1.5 times ULN) • Adequate liver function (total bilirubin ≤ 1.5 times the ULN, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 times ULN Exclusion Criteria: • Presence of active / uncontrolled central nervous system involvement • History of clinically significant cardiac disease; uncontrolled hypertension • Left ventricular ejection fraction (LVEF) < 45 % • Allogeneic stem cell transplant within 100 days before first dose of study drug • Known history of human immunodeficiency virus (HIV) infection • Chronic or active hepatitis B or C, requiring antiviral therapy • Evidence of history of bleeding disorder, dialysis, or coexisting cancer that is distinct in primary site or histology from the cancer evaluated in this study • Serious, uncontrolled infection • Unresolved chronic toxicity > grade 1 from prior therapy • Use of strong CYP3A4 inhibitors or strong inducers within 7 days prior to the start of study treatment and for the duration of the study

We have previously used this approach to demonstrate phenotypic robustness for the antibiotic degradation activity at the natural active site of the GNCA β - lactamase11.

Certainly, reaching high levels of catalysis for increasingly complex reactions will likely require the concomitant evolution, sophistication and specialization of the catalytic machinery at the active site.

Mechanisms for the emergence of completely new active sites must therefore either plausibly exist or at least have existed at the primordial protein stage.

This has been viewed as a «relaxation» of the enzyme active site that is charged with iron - hydrides that are needed for the N2 reduction reaction.

Identification of highly active Fe sites in (Ni, Fe) OOH for electrocatalytic water splitting.

Interestingly, several analogs of MolPort -016-359-762 also showed higher affinities for the active site pocket of RIPK2, suggesting a high preference of this scaffold for the active site pocket.

Furthermore, our identified RIPK2 inhibitors appear to have more affinity for the active site of RIPK2 than others, are more efficacious at inhibition of proliferation, and can effectively resolve lung inflammation and intestinal inflammation more robustly than gefitinib (Fig. 6B; Table 2).

Figure 1B shows the location of the pharmacophoric points identified for the interaction of ponatinib with the RIPK2 active site and the proposed binding modes of the ligands with the lowest binding free energies, respectively.

Site - directed mutagenesis in a biologically active nucleic acid for the purpose of reverse genetics of phage Qß; method extended to DNA to determine structure - function relationships in the promoter and splice sites of the ß - globin gene.

It has also been suggested for serine proteases and other enzymes that binding interactions away from the site of chemical transformation position the substrate such that active site hydrogen bonds are prevented from achieving their optimal length in the ground state.

It also transports cholesterol from extra-hepatic sites, including the arterial wall, to the liver for excretion via reverse cholesterol transport.77 Results from IER (60 - 85 % ER / alternate days) trials have thus far been inconsistent, with some reporting decreases 40, and others increases 37, 39, but with the majority showing no effects on HDL cholesterol levels.38, 42, 43, 45, 49, 51, 52Inconsistencies may have arisen due to the biphasic response of HDL documented by studies of ER induced weight - loss, whereby levels typically decrease during active weight - loss then either return to baseline or (less commonly) rise following attainment of weight stability.78 Complementary increases in HDL levels and particle size have been shown when endurance exercise have been combined with IER 42, 46, 47 however further discussion goes beyond the scope of this review.

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