AML is one of the most deadly types of leukemia and the most common type
of acute leukemia in adults; it increases in frequency as we age.
Those of us who love and esteem him pray for a miracle that will cure the rare
forms of acute leukemia that now afflict him.
Researchers at the University of Michigan Comprehensive Cancer Center have developed a new drug candidate that shows potential in laboratory studies against a rare
type of acute leukemia.
Research on antimetabolites of nucleic acid purines led to drugs for the
treatment of acute leukemia (6 - mercaptopurine and thioguanine), gout and hyperuricemia (allopurinol), and herpesvirus infections (acyclovir), and for the prevention of organ transplant rejection (azathioprine).
One such mutation, found in about 25 %
of acute leukemia patients, involves a gene known as FLT3, which encodes an enzyme called a kinase that usually promotes cell division in a controlled way.
Thomas Look and colleagues use a type of genomic screen and identify abnormal HGF expression as a crucial factor for development of a
class of acute leukemia in leukemia cell lines and clinical samples.
Cancer in general is a devastating disease, but your dog's prognosis is better if he develops the chronic form of canine leukemia
instead of acute leukemia.
Among these, the genes responsible for inherited
forms of acute leukemia and myelodysplastic syndrome are the best characterized.
Leukemia researcher Brian Druker of Oregon Health and Science University praises the work, calling FLT3 «one of the best targets in
all of acute leukemia, because it's one of the most common.»