Sentences with phrase «of adaptive immune cells»

The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2 - mediated Rac activation and actin polymerization.

One study showed that ovarian tumors produce a signaling molecule that serves to attract regulatory T cells, a subclass of adaptive immune cells responsible for quieting other T cells.

Not exact matches

When the dendritic cells are activated, they train T cells — their allies in the adaptive arm of the immune system — to attack cancer cells anywhere in the body, whether at the site of the original tumor or distant metastases.

NKp46 was critical for the subsequent development of antiviral and antibacterial T cell responses, which suggests that the regulation of NK cell function by NKp46 allows for the optimal development of adaptive immune responses.

«This study shows that NF - kB might coordinate a network of immune - suppressor genes whose products enable tumor cells to evade adaptive immunity,» he adds.

T cells, along with B cells and others, comprise the adaptive arm of the immune system, the body's second line of defense which quickly attacks and «remembers» specific pathogens.

A healthy gut depends on a balance of inflammatory and tolerant T cells, which make up part of the adaptive immune system.

The macrophages are capable of killing tumor cells or sending out an alarm to T cells of the adaptive immune system that something is amiss.

As the infection progresses, adaptive immune cells called T cells move to the area of infection, where they detect and kill infected cells.

Areas covered range from basic studies into the biology of innate and adaptive immunity (immune cell development and differentiation, immunogenomics, systems immunology, structural immunology, antigen presentation, immunometabolism, and mucosal immunology) to immune contributions to health and disease (host defense, inflammation, cancer immunology, autoimmunity, allergy, transplantation, and immunodeficiency).

Until now, most researchers have focused on one of two strategies: attacking tumors with antibodies, which activate the innate immune system, or stimulating T cells, which form the backbone of the adaptive immune system.

«Recent successes in cancer immunotherapy — in the form of immune checkpoint inhibitors and adoptive T cell transfer — demonstrate how activated immune cells can eradicate tumors, but until now we didn't fully appreciate immunosurveillance or the role of adaptive immunity in tumor formation,» said senior author Michael Karin, PhD, Distinguished Professor of Pharmacology and Pathology at UC San Diego School of Medicine.

MHC I & II molecules then bind the antigen and present it to different arms of the adaptive immune system, potentially mobilizing T cells, B cells and natural killer (NK) cells.

The researchers are investigating an adaptive immune system, termed CRISPR - Cas, which is found in half of all bacterial species and in almost all single - celled microbes in the archaea domain.

Up until now, efforts in generating a vaccine against TB have been mainly focused on T cells (cells from the adaptive arm of our immune response with memory capacity), with very disappointing outcomes in both pre-clinical as well as clinical trials.

Adaptive immune responses are initiated by the clonal selection of naive T lymphocytes, which recognize their cognate ligands through antigen - specific T cell receptors.

Systemic vs. mucosal immunisation regimens will be compared for optimal induction of innate and adaptive immune cell subsets, including Th1, Th2, Th17, Th22 and regulatory T cells, as well as inflammation genes.

With respect to biological applications, the group is focusing on how cellular heterogeneity and cell - to - cell communication drive ensemble - level decision - making in the immune system, with an emphasis on «two - body» interaction (e.g., host cell - virus interactions, innate immune control of adaptive immunity, tumor infiltration by immune cells).

Our experts in mucosal vaccine delivery have established in vitro and in vivo models to assess the activity of adjuvants and vaccine formulations on innate and adaptive immune cells, as well their capacity to stimulate different effector mechanisms of clearance.

Vα14 invariant NKT (Vα14 iNKT) cells are a population of T lymphocytes that have several unique characteristics; many of these are related to their ability to function similarly to cells of the innate as opposed to the adaptive immune system.

Taking advantage of infected patients, proprietary animal models of infection and new technological advances in the field of static and dynamic imaging, Immunopathology Unit tackles unresolved issues that include the means by which innate and adaptive immune cells traffic and function within the normal, cirrhotic or cancerous livers.

Our laboratory is interested broadly in the interface between the innate and adaptive immune systems, and the unique subsets of T lymphocytes that bridge these systems by adopting properties that are very characteristic of innate immune cells.

The main mechanism includes phagocytosis of macrophages which play a critical role in nonspecific defense (innate immunity) and, moreover; they have a role as antigen presenters which also help initiate specific defense mechanisms (adaptive immunity) by recruiting other immune cells such as lymphocytes.

B cells (bursal or bone marrow - derived cells) are lymphocytes that play a pivotal role in the adaptive immune system and disruption of B cell function is a common hallmark of many different diseases.

In the late 1960s, Rowley and his graduate student Donald Mosier were the first to describe the function of a previously unrecognized cell type, a component of the adaptive immune system they labeled the «A cell,» for its «adherent, accessory or antigen - presenting capacity.»

Immune Regenerative Medicine is the field of medicine which encompasses numerous strategies used to improve the body's healing response in restoring the cells and function of the innate and adaptive immune system.

Adaptive immune cell methylation pattern may be a fingerprint of acute rejection in kidney transplant recipients.

She and her colleagues study the cellular and molecular aspects of the innate and adaptive immune responses (the two arms of the immune system), and more specifically, dendritic cells, a specialized subset of leukocytes that coordinate them.

Topics covered will include how the immune system and commensal microbes interact in the context of health and disease; how dendritic cells respond to infectious or inflammatory stimuli and the roles they play in the induction and polarization of adaptive immune responses against pathogens; how the innate immune pathways regulate inflammation at mucosal barrier tissue sites and how the macrophages are involved in intestinal inflammation.

Adaptive or Acquired Immune System — Also known as the specific immune system, it is composed of highly specialized cells that, when working properly, are specific to a particular pathogen.

For HIV to develop into full - blown AIDS, the virus must deplete a subset of immune cells called CD4 + T cells, disabling an infected person's adaptive immune system in the process.

how dendritic cells respond to infectious or inflammatory stimuli and the roles they play in the induction and polarization of adaptive immune responses against pathogens.

Stimulation of the STING pathway appears essential to generate a de novo immune response comprising tumor cell death, generation of antigens, and activation of the innate and adaptive immune system.

SHP2 also suppresses T - cell activity against growing tumors through regulation of the adaptive immune response by binding to PD - 1 and dephosphorylating CD28 and the protein LCK.

GM - CSF also promotes an inflammatory environment for the adaptive arm of the immune system, especially in Th17 cell biology [64, 65].

The range of subjects includes, but is not limited to, immune cell development and senescence, signal transduction, gene regulation, innate and adaptive immunity, autoimmunity, infectious disease, allergy and asthma, transplantation, and tumor immunology.

This is often enough to halt the infection but the second part of the immune response is adaptive immunity, when dendritic cells activate T lymphocytes and trigger a cascade of immune reactions, such as the formation of antibodies and killer cells that clear the infection from the body and form a memory of the invading pathogen.

B cell immunodeficiencies (adaptive)-- B cells are one of two key cell types of the adaptive immune system.

Data indicate that Dendritic cells (DC) are an early target for HIV and may become a source of virus for the surrounding cells affecting in turn innate and adaptive immune responses.

The strict limit in proliferative potential of normal human somatic cells - a process known as replicative senescence - is highly relevant to the immune system, because clonal expansion is fundamental to adaptive immunity.

T cell immunodeficiencies (adaptive)-- T cells are the second of two key cell types of the adaptive immune system.

Among the diversity of immune cell types, dendritic cells (DCs) are central to the immune response and have the unique capacity to link innate and adaptive immunity.

NK cells are one of the innate immune systems «first responders» that help to control an infection while the adaptive immune responses are gearing up.

T cells form a vital component of our adaptive immune system.

When accompanied by an antigen in protein form, generation of a strong, antigen - specific adaptive immune response characterized by CD4 T cells.

Interleukin 15 (IL - 15) regulates the development, survival, and functions of multiple innate and adaptive immune cells and plays a dual role in promoting both tumor cell growth and antitumor immunity.

Zebrafish have both an innate and adaptive immune system with the full repertoire of immune and inflammatory cells found in mammalian systems.

Persistent inflammation induced by prolonged or repetitive exposure to specific allergens, typically characterized not only by the presence of large numbers of innate and adaptive immune cells (in the form of leukocytes) at the affected site but also by substantial changes in the extracellular matrix and alterations in the number, phenotype and function of structural cells in the affected tissues.

The macrophages release cytokines that can activate more innate immune cells, readying them for attack on viruses or cancer cells, or they can activate the adaptive arm of immunity, priming it for clonal expansion.

This arm of the immune system instructs the «learned» or adaptive system, which employs B cells and T cells to build antibodies that continues to re-recognize the offending agent.