Sentences with phrase «of adaptive immune responses»

This group seeks to dissect the complex dynamics of host - virus interactions with a particular focus on the development and function of adaptive immune responses.

how dendritic cells respond to infectious or inflammatory stimuli and the roles they play in the induction and polarization of adaptive immune responses against pathogens.

Topics covered will include how the immune system and commensal microbes interact in the context of health and disease; how dendritic cells respond to infectious or inflammatory stimuli and the roles they play in the induction and polarization of adaptive immune responses against pathogens; how the innate immune pathways regulate inflammation at mucosal barrier tissue sites and how the macrophages are involved in intestinal inflammation.

NKp46 was critical for the subsequent development of antiviral and antibacterial T cell responses, which suggests that the regulation of NK cell function by NKp46 allows for the optimal development of adaptive immune responses.

SHP2 also suppresses T - cell activity against growing tumors through regulation of the adaptive immune response by binding to PD - 1 and dephosphorylating CD28 and the protein LCK.

Not exact matches

Sian says: «As well the part of our immune system known as «innate immunity», the body also has processes in place called «adaptive immunity» which is when the body recognises a virus it has encountered before and initiates a response.

Polymeric adjuvants in the form of nanoparticles, matrices or micelles have the ability to prompt strong adaptive immune responses without sacrificing biocompatibility.

«An exaggerated inflammatory response among cellular elements of the innate immune system can drive the adaptive immune system down an allergy - associated T H2 pathway,» said Vuillermin.

Strains of bacterial species induce a greatly varied acute adaptive immune response: The contribution of the accessory genome.

The UNC research team, led by Lemon and Jason Whitmire, Ph.D., Associate Professor in UNC's Department of Genetics, is now poised to investigate the complicated interplay of nonspecific «innate» and specific «adaptive» immune responses that ultimately control the infection and eliminate HAV from the host — processes that are not well understood for any of the five human hepatitis viruses.

Dr. Quintana's research is focused on the regulation of the adaptive and innate immune response and the identification of biomarkers for multiple sclerosis (MS) and other immune - mediated diseases.

«An acute stress hormone response is likely to enhance adaptive immunity and wound healing, whereas the sluggish and prolonged elevation» of stress hormones «is likely to impair immune function.»

Following transmission by mosquitoes, the early specific (also called adaptive) immune response to WNV is thought to be dominated by antibodies, and, consistent with this, the researchers found that older mice had less potent WNV - specific antibody responses during the early phase of infection.

Up until now, efforts in generating a vaccine against TB have been mainly focused on T cells (cells from the adaptive arm of our immune response with memory capacity), with very disappointing outcomes in both pre-clinical as well as clinical trials.

They found that an antibody - associated drop in bacteria levels only became apparent after seven weeks and suggest that the adaptive immune response in the gut only begins to mature at six weeks of age.

Adaptive immune responses are initiated by the clonal selection of naive T lymphocytes, which recognize their cognate ligands through antigen - specific T cell receptors.

Noncytolytic control of viral infections by the innate and adaptive immune response.

The group also has experience in the creation of custom panels for the analysis of pathogen specific immune responses with focus on innate and adaptive arms of the immune system.

Furthermore, such multi-omics approaches can identify early signatures / biomarkers predictive of magnitude, quality and / or duration of vaccine - induced adaptive immune responses.

Recently, the crucial involvement of IRFs in innate and adaptive immune responses has been gaining much attention, particularly with the discovery of their role in immunoregulation by Toll - like receptors and other pattern - recognition receptors.

In the paper, the researchers conducted blood tests on a few dozen people and found that the presence of pre-existing adaptive immune responses in humans to either Cas9 homolog «may hinder the safe and efficacious use of the Cas9 / gRNA system to treat disease, and may even result in significant toxicity to patients.»

[14] In the gut, the release of cytokines and chemokines is important in initiating an adaptive immune response.

Immune Regenerative Medicine is the field of medicine which encompasses numerous strategies used to improve the body's healing response in restoring the cells and function of the innate and adaptive immune system.

She and her colleagues study the cellular and molecular aspects of the innate and adaptive immune responses (the two arms of the immune system), and more specifically, dendritic cells, a specialized subset of leukocytes that coordinate them.

Ateba - Ngoa U, Adegnika AA, Zinsou JF, Kassa Kassa RF, Smits H, Massinga - Loembe M, Mordmüller B, Kremsner PG, Yazdanbakhsh M. Cytokine and chemokine profile of the innate and adaptive immune response of schistosoma haematobium and plasmodium falciparum single and co-infected, school - aged children from an endemic area of Lambaréné, Gabon.

The discoveries of the three Nobel laureates have revealed how the innate and adaptive phases of the immune response are activated and thereby provided novel insights into disease mechanisms.

Title: Chemotherapy response of spontaneous mammary tumours is independant of the adaptive immune system Authors: Ciampricotti M, Hau CS, Doornebal CW, Jonkers J, de Visser KE Date: 2012 Publication Details: Nature Medicine 18,344 — 346 (2012) doi: 10.1038 / nm.2652

Stimulation of the STING pathway appears essential to generate a de novo immune response comprising tumor cell death, generation of antigens, and activation of the innate and adaptive immune system.

But the findings, including detailed examination of the bladder and kidney tissue, are consistent with an adaptive immune response stemming from the vaccination, he says.

She also investigates the cellular and molecular mechanisms of innate and adaptive immune responses by RNA vaccines.

This is often enough to halt the infection but the second part of the immune response is adaptive immunity, when dendritic cells activate T lymphocytes and trigger a cascade of immune reactions, such as the formation of antibodies and killer cells that clear the infection from the body and form a memory of the invading pathogen.

Therefore the group studies with sophisticated imaging technology in vitro and ex vivo: i) the molecular mechanism driving the migration of HIV through the intestinal epithelial barrier; ii) the cellular targets in the mucosa, in specific macrophages and DCs, to identify the possible pathways to invade the tissue and disseminate to other organs; iii) the involvement of DCs and their functional properties in mediating adaptive immune responses at mucosal level; and iv) the role of antibodies with different effector functions in changing the pathways of the virus.

In a person with an immunodeficiency disorder, one or more components of either the adaptive or innate immune response is impaired, resulting in the body being unable to effectively resolve infections or disease.

Data indicate that Dendritic cells (DC) are an early target for HIV and may become a source of virus for the surrounding cells affecting in turn innate and adaptive immune responses.

Among the diversity of immune cell types, dendritic cells (DCs) are central to the immune response and have the unique capacity to link innate and adaptive immunity.

Intralesional bacillus Calmette - Guérin and interleukin - 2 have both shown good responses in injected lesions; however, they have had minimal to no effect on noninjected lesions, likely due to inadequate activation of the adaptive immune system.

NK cells are one of the innate immune systems «first responders» that help to control an infection while the adaptive immune responses are gearing up.

HESC have been shown to have reduced immunogenicity, expressing low levels of MHC - I and MHC - II in both the undifferentiated and dedifferentiated state, and to possess an adaptive mechanism to immune responses [60]--[62].

When accompanied by an antigen in protein form, generation of a strong, antigen - specific adaptive immune response characterized by CD4 T cells.

Furthermore, chronic inflammation exacerbates osteoarthritis and autoimmune diseases, decreases the (adaptive immune) response to infections, and is being increasingly recognized as an important cause of premature aging.

Zonulin evolved as an adaptive mechanism to flush out microorganisms as part of the innate immune response against bacterial colonization of the small intestine (Fasano, 2011).

Of the two parts of the immune system, it's the adaptive immune response that declines the mosOf the two parts of the immune system, it's the adaptive immune response that declines the mosof the immune system, it's the adaptive immune response that declines the most.

A different immune mechanism, the innate immune response, comes into play in reactions of gluten sensitivity, as opposed to the long - term adaptive immune response that arises in celiac disease.

''... we propose that lifelong exposure to (exogenous and endogenous) stressors can stimulate local and systemic adaptive responses, including activation of the immune system to incur «physiological inflammation.»

When a healthy person gets sick, the body has a natural immune response which triggers the first line of defense (innate immune response) that then call the second line of defense (adaptive immune response) into action and raise the antibody response.