WEDNESDAY, April 12, 2017 (HealthDay News)-- Close to half of breast cancer patients who chose to have a double mastectomy after genetic testing didn't actually have the gene mutations known to raise the risk
of additional cancers, a new survey found.
«If successful, these new treatments could also be applicable to a variety
of additional cancers in which both genes are overexpressed.»
Not exact matches
HOUSTON, April 20, 2018 (GLOBE NEWSWIRE)-- Bellicum Pharmaceuticals, Inc. (NASDAQ: BLCM) a clinical stage biopharmaceutical company focused on discovering and developing cellular immunotherapies for
cancers and orphan inherited blood disorders, today announced the closing
of its previously announced underwritten public offering
of 9,200,000 shares
of its common stock, including 1,200,000 shares sold pursuant to the underwriters» full exercise
of their option to purchase
additional shares, at a public offering price
of $ 7.50 per share.
Dan Chen, head
of Roche / Genentech's
cancer immunotherapy unit, told Fortune the data were particularly promising since they could lead to Tecentriq becoming a first response treatment and give
additional credence to the company's argument that immunotherapies are more effective the earlier they're given to patients.
In December, SQZ partnered with global pharma firm and
cancer treatment leader F. Hoffmann - La Roche in a deal that could be worth $ 500 million or more — a large undisclosed upfront payment, and
additional sums when SQZ meets certain milestones — to speed up the development
of its technology specifically to inject a person's immune cells with a protein to activate a «killer T» cell response to fight off
cancer.
Buffett, 81, said his «condition is not remotely life - threatening or even debilitating in any meaningful way,» and that
additional tests didn't reveal incidence
of cancer anywhere else in his body.
In particular, sales
of prostate
cancer treatment Zytiga and anti-immune biologic Stelara grew the most in pure dollar terms, with the U.S. Food and Drug Administration having approved an
additional indication for Zytiga to help boost its revenue.
Conducted at the MD Anderson
Cancer Center, the study shows «
additional insight into just how meaningful poziotinib may be in this area
of high unmet need,» according to CEO Joe Turgeon.
Some experts predicted that the depletion
of ozone in the stratosphere due to the exhausts from the SST would produce about 10,000
additional cases
of skin
cancer in the world.
It also promotes anti-angiogenesis, meaning it helps prevent the development
of additional blood supply necessary for
cancer cell growth.
We realize that children
of cancer patients have
additional needs - and we address them by giving them extra attention and support.
It doesn't hurt that they have great sales and I purchase their breast
cancer card to get
additional 25 % off on top
of my purchase.
Cuomo said the law now requires insurance coverage
of screening - associated costs, support services and breast
cancer screening centers to be open an
additional four hours a week, after 5 p.m. or on weekends.
Health Secretary Jeremy Hunt said: «Radiotherapy is one
of the most clinically and cost - effective treatments for
cancer and this funding will bring our
additional investment in radiotherapy over the Spending Review period to # 165 million.»
Volunteer firefighters say they are at greater risk than the general population
of contracting
cancer due to toxins they encounter on calls, and they are pushing for
additional medical coverage through state legislation.
Cuomo said the law now requires insurance coverage
of screening - associated costs, support services and breast
cancer screening centers to be open an
additional four hours week, after 5 p.m. or on weekends.
In his proposed state budget, Cuomo also has proposed $ 11 million in funding to hire
additional health care workers at
cancer treatment facilities for outreach work, $ 15 million for public education campaigns targeting underserved communities, and $ 5 million to support commercialization
of cancer - related technologies.
Because
of this, it is necessary to offer
additional benefits and protections to all firefighters so that if they do develop
cancer, they are not left alone.
I hope that Governor Cuomo will sign this law as soon as possible to expand the Volunteer Firefighters» Benefits Law to include
additional forms
of cancer that are connected to the hazardous materials that volunteers come in contact with while on duty.
While the combination therapies block off the principal pathway that
cancer cells use to fuel their growth, the cells come to bypass this blockade and, like vehicles on a detour route, make use
of additional pathways to continue growing and spreading.
After an hour - long informational session, a follow - up questionnaire found that nearly all attendees were able to correctly answer questions about the rationale for screening, the difference between the need for
additional testing and a
cancer diagnosis, the benefit
of negative screenings as a baseline for future comparisons, and the continued importance
of physical examinations.
Study authors intend to perform
additional research in the future to follow up on their estimate
of how well the current vaccines protect against HPV - associated
cancers.
«Considering the marked prevalence
of both prostate
cancer and depression,
additional efforts are needed to better understand and ameliorate the decreased survival following prostate
cancer diagnosis in the depressed male patient.
Although mutations can occur anywhere in the human intestine, certain types
of colorectal
cancer tend to develop in particular locations, suggesting that
additional, nongenetic factors contribute to tumor growth and dictate where polyps appear.
NRG Oncology / RTOG 0232 is a phase III, multi-institutional trial conducted at 68
cancer centers throughout the U.S. and Canada from 2003 to 2012 to assess whether adding EBT to transperineal interstitial permanent brachytherapy conveyed an
additional benefit in progression free survival (PFS), or control
of the
cancer growth, at five years following treatment.
Additional U.S. institutions that participated in the trial include University
of Texas MD Anderson
Cancer Center, Stanford
Cancer Institute, University
of Chicago, University
of Michigan, and Dana - Farber
Cancer Institute.
Professor Ali Tavassoli, who led the study with colleague Dr. Ishna Mistry, explains: «In an effort to better understand the role
of HIF - 1 in
cancer, and to demonstrate the potential for inhibiting this protein in
cancer therapy, we engineered a human cell line with an
additional genetic circuit that produces the HIF - 1 inhibiting molecule when placed in a hypoxic environment.
An international team
of researchers has identified eight
additional types
of cancer linked to excess weight and obesity: stomach, liver, gall bladder, pancreas, ovary, meningioma (a type
of brain tumor), thyroid
cancer and the blood
cancer multiple myeloma.
WHO noted that females have a 0.75 % lifetime risk
of developing thyroid
cancer; it estimated that the highest exposures in the Fukushima area raised that risk by an
additional 0.5 %.
For
additional ways to protect your skin from the sun and reduce your risk
of skin
cancer, visit the Academy's SpotSkinCancer.org.
However,
additional research, including more formal mediation analyses, on the underlying mechanisms for the recreational physical activity -
cancer association should be pursued vigorously,» writes Marilie D. Gammon, Ph.D.,
of the University
of North Carolina at Chapel Hill Gillings School
of Public Health, and coauthors in a related commentary.
«However, patients eventually experience progression
of cancer on this treatment, highlighting the need for
additional therapies.
The findings
of this study may be useful for planning future support programs for
cancer patients, and can provide
additional information to guide programs for people with specific
cancer types.
The results
of this trial are encouraging and deserve
additional testing prior to becoming a standard
of care for patients with advanced pancreatic
cancer.
Raquel Oliveira, first author
of this study, explains: «Many
cancer cells have these type
of chromosomal abnormalities and we now show that this can bring
additional problems every time a cell divides.»
«In upcoming decades, an increasing proportion
of breast
cancer patients will be elderly and, therefore, the
additional costs
of treating over-diagnosed tumors could result in a tremendous increase in health expenditure, while no actual health benefits are being obtained.
It includes numerous policy recommendations and a laundry list
of projects by the National
Cancer Institute (NCI) and other federal agencies that would require
additional funding.
«However,
additional research is needed to further evaluate the therapy for this type
of ovarian
cancer.»
The report, drafted by a panel
of international experts in radiation risks and public health, concluded that there was no
additional cancer risk for the population in most
of Japan — even most parts
of Fukushima Prefecture — or in neighboring countries.
«The increased risk is such that if Canada was to switch over to a system
of private, for - profit hospitals, we would expect an
additional 2200 Canadians to die each year,» says the cardiologist, adding that this number is comparable to that
of Canadians dying each year in motor vehicle accidents or from colorectal
cancer.
Women who have a genetic mutation face a higher risk
of developing a second breast
cancer and may wish to consider more aggressive treatment, preventive measures or
additional screening.
Based on the pioneering work
of Dr. Claire Lugassy and Dr. Raymond Barnhill at UCLA's Jonsson Comprehensive
Cancer Center, a new study provides additional support for a process by which melanoma cells, a deadly form of skin cancer, can spread throughout the body by creeping like tiny spiders along the outside of blood vessels without ever entering the blood stream, and that this process is exacerbated by exposure to ultraviolet (UV)
Cancer Center, a new study provides
additional support for a process by which melanoma cells, a deadly form
of skin
cancer, can spread throughout the body by creeping like tiny spiders along the outside of blood vessels without ever entering the blood stream, and that this process is exacerbated by exposure to ultraviolet (UV)
cancer, can spread throughout the body by creeping like tiny spiders along the outside
of blood vessels without ever entering the blood stream, and that this process is exacerbated by exposure to ultraviolet (UV) light.
«The promising safety results
of these early trials set the stage for
additional HCQ trials in different
cancers, and trials involving new autophagy inhibitors that are being developed by pharmaceutical companies,» said Amaravadi.
Specifically, they found that chemotherapy alone leads to two types
of dormant
cancer cells that are not killed outright and become resistant to
additional chemotherapy, but when combined with immunotherapy, a majority
of dormant cells also is destroyed.
«
Additional studies are needed to see if these nanoparticles could also effectively deliver other antitumor genes for the treatment
of brain tumors as well as systemic
cancers.»
«Recent studies have reported supplemental
cancer detection rates
of 1.9 per 1,000 women screened with automated whole breast ultrasound and 1.2 to 2.8 per 1,000 women screened with digital breast tomosynthesis, so our finding
of an
additional 8.8
cancers per 1,000 women makes MBI a very compelling option for women who elect supplemental screening,» says Dr. Rhodes.
Additional experiments using a combination
of maraviroc and a drug that blocks the VEGF protein suggest that the treatment duo could be an effective way to prevent metastatic disease in human breast
cancer patients, according to the researchers.
miR - 34a could have an
additional therapeutic application, offering protection from bone metastases in a variety
of cancers, Dr. Wan noted.
«These findings suggest that MBI has a more favorable balance
of additional invasive
cancers detected versus
additional biopsies incurred relative to other supplemental screening options.»
They also estimate that a population - wide 1 kg / m ² increase in average BMI (roughly an extra 3 to 4 kg, or 8 to 10 pounds, per adult), which would occur every 12 years or so based on recent trends, would result in an
additional 3790 cases
of these 10
cancers in the UK each year.