Sentences with phrase «of additional genes»

There is evidence that the expression of hundreds of additional genes in adult rats changes in response to differences in maternal care [19].

[17] Mutations of additional genes have been implicated in the pathogenesis of Kallmann syndrome and / or hypogonadotropic hypogonadism, including the following genes: WDR11, FGF17, IL17RD, DUSP6, SPRY4, FLRT3, AXL, SOX10, SEMA3A, and HS6ST11.

«We generated over 600 engineered tobacco plant lines that harbour different combinations of these additional genes, and analysed them in terms of the amounts of artemisinic compounds they acquired.

The first steps in this have already been accomplished with the transplanting of additional genes for growth hormone into sheep in Australia to produce larger animals and therefore more wool.

Not exact matches

What if these «maternal sensitivity» genes have the additional, independent effect of making it easier for children to develop strong executive function skills?

Gene Cilento of the state Department of Transportation said while the trucks may be a separate issue requiring additional consideration, he said the I - 81 project is a balancing act trying to benefit the most people while negatively impacting the fewest.

The researchers then found that these same genes carry an additional risk for a phenomenon called spreading depolarization, a slowly - progressing, temporary electrical blackout of a region in the brain.

If Rudenko confirms Clark's PCR tests using additional gene targets, and if Clark or Rudenko manage to grow Borrelia cultures out of human and lone star tick samples, then even the fiercest skeptics will have to recognize that Southern Lyme strains threaten human health, and that Lyme - like illness deserves Lyme - like treatment.

Apparently, NPAS4 accounts for some addiction - related learning and memory processes in the brain, but not all of them, meaning that HDAC5 must be regulating additional genes that reduce relapse events.

The disorder arises when some or all of an extra copy of chromosome 21 is present, but exactly how this additional set of genes disrupts development, leading to learning difficulties and other symptoms of Down's, isn't clear.

In an additional group of endometriosis samples biopsied from 15 women at the University of British Columbia, the scientists looked specifically for mutations in the KRAS gene, whose expression signals proteins that spur cell growth and replication.

Our data demonstrate the feasibility of targeted gene disruption in multiple rat strains within 4 months time, paving the way to a humanized monoclonal antibody platform and additional human disease models.

An additional study, currently available at bioRxiv, led by the researchers from the CRG and Cold Spring Harbour Laboratory, highlights the fact that a substantial part of human and mice genes have maintained an essentially constant expression throughout evolution, in tissues and various organs.

The IGF1 protein is crucial for the growth of mammals, including mice and humans, so Ostrander's group and other collaborators began collecting DNA from additional breeds to see if they also shared the same gene variant.

Then a bath of additional TB - sensitive antibodies, modified with a gene that produces fluorescence, is added.

In experiments on cell cultures, both of these inhibitors succeeded in breaking various forms of the TKI resistance: including forms caused by additional mutations of the gene Bcr - Abl as well as those caused by large quantities of the protein Gab2.

And five months later, Jerry Shay and Woodring Wright of University of Texas Southwestern Medical Center, also working with Geron collaborators, published additional findings, showing that, by introducing the hTRT gene to cells, they could make those cells repair unraveling telomeres.

«Our stem cell - based studies indicate that low - calorie sweeteners promote additional fat accumulation within cells compared with cells not exposed to these substances, in a dose - dependent fashion — meaning that as the dose of sucralose is increased more cells showed increased fat droplet accumulation,» said Sabyasachi Sen, M.D., Associate Professor of Medicine at George Washington University in Washington, D.C. «This most likely occurs by increasing glucose entry into cells through increased activity of genes called glucose transporters.»

Before the consortium came together, he had participated in sequencing the genomes of two vocal learners, a songbird and a parrot, but he knew he couldn't do all of the additional sequencing and analysis work that would be required to identify genes related to vocal learning — not by himself, at least — so he teamed up with Genome 10K, a project aiming to collect genomes for 10,000 vertebrate species.

Because environmental exposures have not had time to impact IBD progression in children, researchers have a clearer genetic picture of the disease allowing them to pick out additional genes overlooked in adult research, says senior study author Hakon Hakonarson, director of the Center for Applied Genomics at The Children's Hospital of Philadelphia.

Indeed, all of the tumors from patients who carried this particular T - to - A mutation also had additional mutations that inactivate the APC gene.

Using this method, the researchers found 91 genes missing from one or more virulent strains of M. bovis (8 strains total) and an additional 38 genes missing from some or all strains of BCG (13 strains total).

Many of the additional 38 missing genes looked like they coded for proteins involved in controlling the activity of other genes.

A variant of the gene that allowed additional cell divisions, Lahn surmises, gave some hominids the additional neural infrastructure that eventually let them develop abstract reasoning and language skills.

Additional experiments revealed that SIRT1 stymies PPARγ, which is known to jack up the activity of several genes that boost fat production.

Additional support could come from the chimpanzee genome, which may allow researchers to clock when the genes for slow - twitch muscle fibers — crucial for running long distances and plentiful in people but not chimps — diverged in the common evolutionary history of humans and apes.

The cutting edge, however, is «gene doping,» in which additional copies of a naturally - occurring gene or modified copies may be inserted into an athlete's genome using a virus carrier.

This new gene expression data therefore provides additional evidence that the altered behavior of bacteria in space results from decreased gravity driving reduced extracellular transport of molecules.

The function of these genes were involved in molecular maintenance strategies, such as DNA repair, chromosomal maintenance, immune response and programmed cell death The authors argue that the «slower rate of change in these functions is consistent with increased constraint on somatic cell maintenance as would be required in these relatively long - lived and large - bodied mammals, illustrated by the additional large and long - lived species with slower rates in these genes (e.g. double - strand break repair gene XRCC4 is also highly constrained in elephant.»

Additional research is also needed to determine how the C version of the gene affects the protein's function.

«Additional studies are needed to see if these nanoparticles could also effectively deliver other antitumor genes for the treatment of brain tumors as well as systemic cancers.»

«If successful, these new treatments could also be applicable to a variety of additional cancers in which both genes are overexpressed.»

«This knowledge will facilitate identification and isolation of additional resistance genes for improved control of Septoria,» adds Kanyuka.

A family of neuropeptide genes which includes the gene encoding ELH along with two additional genes encoding the A and B peptides thought to initiate the egg - laying process has been isolated and their nucleotide sequence has been determined.

Importantly, the small remnants of the messenger RNA can then function like additional microRNAs, binding to other copies of the messenger RNA, causing further gene silencing.

The researchers considered two possible explanations: Disease suppression might be the result of one or two additional substitutions on the same gene that buffer the harmful effect of the mutation; or suppression may be caused by numerous small substitutions throughout the genome that form an aggregate «shield.»

Next they tested an additional 27 genes that are known to be involved in various steps of ribosome biogenesis to verify whether SSUP was required for ESC maintenance.

Center for Elephant Conservation, elephants have 38 additional modified copies (alleles) of a gene that encodes p53, a well - defined tumor suppressor, as compared to humans, who have only two.

The social velvet spider's genome, however, revealed 10 genes just for that one kind of silk and nine other genes for additional silk proteins.

They found additional changes to the small number of genes carried within the mitochondria, the cell's powerhouses.

If a woman with a strong family history of breast and ovarian cancers tests negative for the BRCA1 / 2 genes, that does not mean her relatives are not at risk, says Daly — her siblings could still carry the gene, or there could be additional genes present that predispose them to cancer that clinicians don't yet know how to test for.

Additional validation was undertaken in separate studies of children with meningococcal disease (n = 24) and inflammatory diseases (n = 48) and on published gene expression datasets.

That means that there's a lot of additional information here, outside of where genes are expressed,» he says.

But in a polyploid organism such as wheat, mutations in individual genes often have no apparent effect, because additional copies of the mutated gene compensate for the loss.

The team then used their best transplastomic tobacco plant line to introduce an additional set of genes into its nuclear genome, generating the COSTREL lines.

Additional genes included in the database could be the focus of future drug development efforts because they belong to classes of genes that are thought to make promising drug targets.

To further explore nuclear transport's role in Huntington's disease, Grima took lab - grown mouse neurons and used chemical switches to a) turn on both an additional healthy copy of the RanGAP1 gene and a mutant version of Huntingtin; b) just turn on the mutant Huntingtin; or c) just turn on a healthy version of Huntingtin.

But they provide additional gene markers in bipolar disorder that could potentially lead to the future development of diagnostics or treatments.»

Beyond the seven genes linked to CoQ, «our ongoing analysis has already led to some 20 additional predictions of protein function, and each could become a thesis project,» says Pagliarini.

Additional micro-patterning of the substrate changes the cytoskeleton in the cell and the shape of the nucleus, which cause the genes in the cell to change.