Sentences with phrase «of additional tumors»

More targeted sequencing of additional tumors was conducted to track how instructions encoded in DNA were translated into the proteins that do the work of cells.

The mean age of the K: B fusion population was 7.4 years old, compared to 15.2 years old in the non-K: B population; 73 percent of the K: B PAs were found in the cerebellum, whereas 78 percent of the non-K: B PAs were found elsewhere; and non-K: B PAs were much more likely associated with co-occurrence of the disease Type 1 Neurofibromatosis, which can lead to the formation of additional tumors.

The influx of additional tumor - attacking cells pushed the cancer to regress in about half the patients (Science, 25 October 2002, p. 850).

Not exact matches

Of the seven comments, someone suggests additional x-rays while another commenter asks if it could be a hemangioma, a benign tumor.

This additional information will help in the next steps of the research, which involve more detailed study of the PD - 1 at different points in its pathway and with different viral or tumor loads.

Although mutations can occur anywhere in the human intestine, certain types of colorectal cancer tend to develop in particular locations, suggesting that additional, nongenetic factors contribute to tumor growth and dictate where polyps appear.

An international team of researchers has identified eight additional types of cancer linked to excess weight and obesity: stomach, liver, gall bladder, pancreas, ovary, meningioma (a type of brain tumor), thyroid cancer and the blood cancer multiple myeloma.

Indeed, all of the tumors from patients who carried this particular T - to - A mutation also had additional mutations that inactivate the APC gene.

«One of the major and immediate downstream effects of myc activation is a dramatic increase in the capacity of affected cells to make protein,» Ruggero said «This, in turn, leads to increased cell survival and proliferation, and to unstable genomes that foster additional mutations that turn these abnormal cells into tumor cells.»

«In upcoming decades, an increasing proportion of breast cancer patients will be elderly and, therefore, the additional costs of treating over-diagnosed tumors could result in a tremendous increase in health expenditure, while no actual health benefits are being obtained.

This lengthy period of time, compared to a mouse's lifetime, indicates that additional factors play a role in tumor development.

«Additional studies are needed to see if these nanoparticles could also effectively deliver other antitumor genes for the treatment of brain tumors as well as systemic cancers.»

Additional studies suggest that f - circM9 may also help tumor cells persist in the face of anti-cancer drugs.

Center for Elephant Conservation, elephants have 38 additional modified copies (alleles) of a gene that encodes p53, a well - defined tumor suppressor, as compared to humans, who have only two.

The additional seven patients lived incrementally longer than one would have predicted based on the number of previous treatments they received and the multifocal nature of the GBM tumor recurrences.

The researchers found that OTL38 accumulated in FRα - positive tumors and metastases, and enabled the surgeons to remove an additional 29 percent of malignant lesions (confirmed by pathological examination of the resected tumors) that could not be identified with naked eyes and / or palpation.

A newly devised tumor - specific fluorescent agent and imaging system guided surgeons in real time to remove additional tumors in ovarian cancer patients that were not visible without fluorescence or could not be felt during surgery, reports Alexander L. Vahrmeijer MD, PhD, head of the Image - guided Surgery group in the Department of Surgery at Leiden University Medical Center in the Netherlands.

In cases where there are lots of T cells in the vicinity of a tumor, or where tumor cells have undergone large numbers of mutations, which creates additional targets for immune sentries, T cells will signal a full - fledged immune response to the cancer.

An additional set of 18 prostate cancer tissue samples was analyzed by qPCR and five lncRNAs were found to be significantly higher in prostate tumor tissues compared with matched normal tissues.

Antibodies stimulate the recruitment of additional immune cells that help to activate T cells; the vaccine stimulates proliferation of T cells that can attack the tumor; IL - 2 helps the T cell population to expand quickly; and the anti-PD1 molecule helps T cells stay active longer.

The team conducted additional experiments in which mouse breast tumors were sampled to generate so - called organoids — spheres of cells that grow in three - dimensional culture.

A new study focused on describing genetic variations within a primary tumor, differences between the primary and a metastatic branch of that tumor, and additional diversity found in tumor DNA in the blood stream could help physicians make better treatment choices for patients with gastric and esophageal adenocarcinoma.

«If our findings are confirmed by additional studies, they may open doors to the development of targeted therapies against the tumor subtypes more likely to affect African Americans and potentially help reduce racial disparities in breast cancer.»

The identification of patients with high - risk breast cancer is key to knowing whether a patient will require only the removal of the tumor by surgery or whether if she will need additional chemotherapy to make sure the removal of breast cancer cells.

Polyploid cells, which carry additional copies of important tumor suppressor genes, are better protected and more resistant to cancer formation because they have these extra copies of the genome,» said Dr. Zhu, who is also an Assistant Professor of Pediatrics and Internal Medicine at UT Southwestern.

Once the tumors are established in the mice, the researchers can introduce additional mutations at any time, allowing them to study the influence of each mutation on tumor initiation, progression, and metastasis.

So, for example, if one type of immunotherapy is used to knock out an inhibitory signal produced by a cancer, and the tumor responds by upregulating a second signal, an additional therapy could then be used to target this one as well, Lu says.

The DNA of their tumors also contained those additional cancer drivers.

Nine additional patients had recurrence within the involved lobe (range, 0.1 to 5.9 years after SBRT), resulting in a five - year primary tumor and involved lobe (local) failure rate of 20 percent.

Additional studies in which we more precisely define the mechanisms of resistance and growth in an individual's tumor with genomic sequencing, and other means, will be important to maximize the ability to target all the critical pathways to achieve greater success.»

In order to determine whether reduced miR - 192 levels are only a chance side effect of cancer and inflammation or whether they in fact influence tumor progression, the investigators equipped pancreatic cancer cells with additional miR - 192.

In additional preliminary tests, Callmann and colleagues were able to halt the growth of the tumors for a least two weeks, using a single lower dose of the drug.

Additional evidence supporting the tumor - promoting role of inflammation is the observation that individuals with chronic inflammation are more susceptible to cancers at the site of that inflammation — e.g. patients with Crohn's disease show increased incidence of colorectal cancer.

Another collaboration was unfolding among the cancer geneticists, sequencing experts, clinical researchers, and surgical oncologists at Johns Hopkins, MD Anderson, and Baylor College of Medicine to study 32 pairs of head and neck tumor and normal tissue samples by whole - exome sequencing and validate the findings in an additional 88 samples.

Additional studies are attempting to determine if the transgene expression of various anti-apoptotic genes can protect T cells from tumor - induced apoptosis.

About 35 % of additional LCH tumors have mutations in related genes, Campbell says.

Significant pre-clinical data demonstrates that TheraT ® is a powerful modality capable of turning «cold tumors hot» which should result in an additional layer of efficacy in the fight against solid tumors.

[69,72] In gastrointestinal stromal tumors (GIST), secondary resistance to KIT inhibition is caused primarily by development of additional KIT mutations.

Total 4E - BP1 and p - 4E - BP1 was predominantly cytoplasmic, although additional nuclear localization was seen in a small subset of tumor cells.

That, in turn, generates free radicals — unstable molecules that can damage DNA, creating additional mutations that allow the tumor to become more invasive, infiltrating tissues and migrating to other parts of the body.

A cancer cell is a cabin that wants to expand (cell growth) and then build a cluster of additional cabins to create a tumor (cell division).

In this case, the weakened version of the typically food - borne bacterium won't make patients sick, rather has the additional benefit of further rousing the attention of the immune system and quietening the tumor's ability to defend itself, Ghamande said.

«The additional information we can now derive from tumor biomarkers such as E-cadherin, nm23 and microvessel counts should begin to allow us to tailor therapy according to individual tumor types,» added Samuel Hellman, MD, A.N. Pritzker Distinguished Service Professor of radiation and cellular oncology at the University of Chicago and co-author of the paper.

According to an international clinical trial led by Sylvia Adams, MD, associate professor of medicine, breast tumors shrank by more than 30 percent in 12 (23 percent) of 52 patients who received pembrolizumab as first - line therapy, and the disease stabilized in 9 additional patients (17 percent).

More recently, we elucidated an additional mechanism of tumor suppression mediated by canonical ephrin - induced EphA2 signaling (Figure 1A), which leads to inhibition of the AKT - mTORC1 oncogenic pathway through interplay of EphA2 with a phosphatase that dephosphorylates the AKT serine / threonine kinase.

In this study, human lung cancer cells with additional copies of the opioid receptor grew more than twice as fast as tumor cells that lacked extra receptors when transplanted into mice.

Two additional tumors had a substantially reduced proportion of mutations attributed to MMR deficiency, where the predominant mutational signatures were related to APOBEC enzymatic activity.

Vogelstein has gone on to investigate additional genes involved in colon cancer such as APC, mutations of which lead to colorectal tumors, and PIK3CA, whose mutations turn benign tumors malignant.

In summary, stromal collagen alignment may provide additional, clinically - relevant information about PDAC tumors and underscores the importance of stroma - cancer interactions.

The progression of the ancestral tumor cell to a full - blown cancer results from the sequential acquisition of additional mutations that confer a selective growth advantage to the original clone.