Sentences with phrase «of adenosine in»

Caffeine is an adenosine antagonist, and the accumulation of adenosine in the brain throughout the day is thought to be a chemical mediator of sleep pressure.

Caffeine has the ability to block the actions of adenosine in the brain for a short period, which explains why caffeine helps to keep us alert.

As you might expect, the act of sleeping reduces the amount of adenosine in the body.

We discovered that these MCs are the primary source of high levels of adenosine in tumor tissue, achieved via unique co-expression of CD39 and CD73 and regulated by TGFβ.

Led by researchers at NYU Langone Medical Center, the study found that maintaining high levels of adenosine in rats with damage to the anterior cruciate ligament (ACL), which is known to lead to osteoarthritis in humans, prevented the rats from developing the disease.

«The effect of sleep deprivation on pain sensitivity in operated and intact rats was virtually eliminated by pharmacologically blocking the action of adenosine in a brain region in the anterior hypothalamus known to regulate sleep, which is connected to major pain - related areas,» Vanini says.

«Caffeine in coffee and other beverages blocks the actions of adenosine in the brain.

Not exact matches

Beef also contains a natural form of creatine, which aids in the production of adenosine - triphosphate or ATP, which is another key to producing lean muscle mass.

How did your body ever come to process energy in the form of adenosine triphosphate (ATP) when ATP is required to make ATP?

Morrison explains Kaivac's SystemSure Plus measures adenosine triphosphate (ATP), which is an energy molecule found in all animal, plant, bacterial, yeast and mold cells, all of which should be significantly reduced after cleaning.

Stored in the muscles, it helps regenerate adenosine triphosphate (ATP), one of the body's sources of quick energy.

It can be thought of like the mitochondria in the cells that produce adenosine triphosphate (ATP), or energy.

Mitochondria, specialized organelles found in nearly every cell of the body, use cellular respiration to generate one of the most important sources of chemical energy — adenosine triphosphate (ATP), a versatile nucleotide that powers everything from cell division to cell signaling to transportation of large molecules across the cell membrane.

Adenosine 3», 5» - monophosphate at a concentration of 5 x 10 - 7 mole per liter causes a 400 percent increase in the rate of phosphorylation of histone catalyzed by a partially purified enzyme preparation from rabbit brain.

The presence of synthetic ovine corticotropin - releasing factor leads to a rapid and marked stimulation of adenosine 3», 5» - monophosphate accumulation in an enriched population of rat pituitary corticotrophs in primary culture.

The data provide the first direct evidence of a biochemical action of adenosine 3», 5» - monophosphate in the brain.

In fact, both of the studies found that when adenosine was turned on in mouse tissue by other mechanisms, the pain response was equal to or better than the response generated by acupuncturIn fact, both of the studies found that when adenosine was turned on in mouse tissue by other mechanisms, the pain response was equal to or better than the response generated by acupuncturin mouse tissue by other mechanisms, the pain response was equal to or better than the response generated by acupuncture.

The researchers reported a 24-fold increase in adenosine concentration in the blood of the animals after acupuncture, which corresponded to a two - thirds reduction in discomfort, as revealed by how quickly they recoiled from heat and touch.

For this reason, Salvemini and colleagues teamed up with researchers from the National Institutes of Health, the University of Arizona and two institutes in Quebec, Canada, to investigate a new target for treating chronic pain: the A3 adenosine receptor or A3AR.

Recognizing this, He and his research team developed a way to reduce the amount of chemical energy — adenosine triphosphate (ATP)-- available to the efflux pumps in cancer cells.

In a study published in the April issue of the Journal of Neuroscience, Saint Louis University scientists led by professor of pharmacological and physiological sciences Daniela Salvemini, Ph.D., discovered that drugs targeting the A3 adenosine receptor can «turn off» pain signals in the spinal cord to provide relief from chronic paiIn a study published in the April issue of the Journal of Neuroscience, Saint Louis University scientists led by professor of pharmacological and physiological sciences Daniela Salvemini, Ph.D., discovered that drugs targeting the A3 adenosine receptor can «turn off» pain signals in the spinal cord to provide relief from chronic paiin the April issue of the Journal of Neuroscience, Saint Louis University scientists led by professor of pharmacological and physiological sciences Daniela Salvemini, Ph.D., discovered that drugs targeting the A3 adenosine receptor can «turn off» pain signals in the spinal cord to provide relief from chronic paiin the spinal cord to provide relief from chronic pain.

But the effects of adenosine had never been demonstrated in live animals, says Robert McCarley, a neurophysiologist at Harvard Medical School.

Researchers showed that limiting the supply or the function of the neuromodulator adenosine in a brain structure called the auditory thalamus preserved the ability of adult mice to learn from passive exposure to sound much as young children learn from the soundscape of their world.

Researchers at the University of California San Diego have discovered an easy and efficient way to coax human pluripotent stem cells to regenerate bone tissue — by feeding them adenosine, a naturally occurring molecule in the body.

Deletion of this enzyme returned the adenosine level in adult mice to the level of newborn mice.

«By disrupting adenosine signaling in the auditory thalamus, we have extended the window for auditory learning for the longest period yet reported, well into adulthood and far beyond the usual critical period in mice,» said corresponding author Stanislav Zakharenko, M.D., Ph.D., a member of the St. Jude Department of Developmental Neurobiology.

In another landmark success, scientists in Italy and the United States cured «bubble» babies who have a malfunctioning gene for the enzyme adenosine deaminase, which causes a buildup of toxic products that destroy immune cellIn another landmark success, scientists in Italy and the United States cured «bubble» babies who have a malfunctioning gene for the enzyme adenosine deaminase, which causes a buildup of toxic products that destroy immune cellin Italy and the United States cured «bubble» babies who have a malfunctioning gene for the enzyme adenosine deaminase, which causes a buildup of toxic products that destroy immune cells.

The serotonin simply crossed the synapse and temporarily modified proteins in the membrane of the target cell, leading to production of messenger chemicals such as CAMP (cyclic adenosine monophosphate).

The existence of this enzyme may account for the increased amount of adenosine 3», 5» monophosphate associated with synaptic activity in the ganglion.

C. elegans is a microscopic worm that like humans highly expresses a family of proteins in the nervous system called ADARs — adenosine deaminases that act on RNA — a family that includes ADR - 1.

The results suggest that the physiological effects of dopamine in the ganglion, and possibly elsewhere in the nervous system, may be mediated by stimulating the synthesis of adenosine 3», 5» - monophosphate.

In this pathway, dopamine - and an adenosine 3 ′, 5 ′ - monophosphate (cAMP)-- regulated phospho - protein of 32 kilodaltons (DARPP - 32) is phosphorylated or dephosphorylated at three sites, in a pattern predicted to cause a synergistic inhibition of protein phosphatase — 1 and concomitant regulation of its downstream effector proteins glycogen synthesis kinase — 3 (GSK - 3), cAMP response element — binding protein (CREB), and c - FoIn this pathway, dopamine - and an adenosine 3 ′, 5 ′ - monophosphate (cAMP)-- regulated phospho - protein of 32 kilodaltons (DARPP - 32) is phosphorylated or dephosphorylated at three sites, in a pattern predicted to cause a synergistic inhibition of protein phosphatase — 1 and concomitant regulation of its downstream effector proteins glycogen synthesis kinase — 3 (GSK - 3), cAMP response element — binding protein (CREB), and c - Foin a pattern predicted to cause a synergistic inhibition of protein phosphatase — 1 and concomitant regulation of its downstream effector proteins glycogen synthesis kinase — 3 (GSK - 3), cAMP response element — binding protein (CREB), and c - Fos.

But recent data hinted that the drug might also have an effect on the mitochondria, organelles that act as cells» powerhouses, producing energy in the form of adenosine triphosphate (ATP).

When oxygen combines with calcium, adenosine triphosphate (ATP) and the chemical luciferin in the presence of luciferase, a bioluminescent enzyme, light is produced.

There are many causes of this disorder; in Katlyn's case it was lack of the enzyme adenosine deaminase, or ADA, which rids the body of a natural toxin called deoxyadenosine.

Caffeine potentiated responses of mushroom body neurons involved in olfactory learning and memory by acting as an adenosine receptor antagonist.

Animals also make use of quinones in metabolism, «to build the pH gradient which drives synthesis of ATP, or adenosine triphosphate,» he adds.

The researchers focused on astrocytes after their initial finding that patients with Alzheimer's disease have unusually high numbers of adenosine receptors in these cells.

In a new report published in the January 2015 issue of the FASEB Journal, scientists use mice to show that a human membrane - bound enzyme called CD39, which can clear the dangerous buildup of adenosine triphosphate (ATP) from the bloodstream, significantly improves survival of mice in sepsiIn a new report published in the January 2015 issue of the FASEB Journal, scientists use mice to show that a human membrane - bound enzyme called CD39, which can clear the dangerous buildup of adenosine triphosphate (ATP) from the bloodstream, significantly improves survival of mice in sepsiin the January 2015 issue of the FASEB Journal, scientists use mice to show that a human membrane - bound enzyme called CD39, which can clear the dangerous buildup of adenosine triphosphate (ATP) from the bloodstream, significantly improves survival of mice in sepsiin sepsis.

That base, an adenosine, is conserved in organisms throughout the tree of life, he reports, and it could well date back to the RNA world.

Taking this one step further, the researchers performed the same experiments in a mouse model of Alzheimer's disease to see if these astrocytic adenosine receptors were also involved in memory loss associated with the disease.

«Next, we will explore the therapeutic implications of our discovery by repurposing available drugs that block these adenosine receptors and are well tolerated in humans.»

The difference in the concentration of protons across these two environments enabled protons to flow into the cell, driving the production of a molecule called adenosine triphosphate (ATP) which powered the growth of cells, just as it does today.

The difference is that Keeling's parasites steal energy, in the form of a molecule called adenosine triphosphate or ATP, from their hosts, but they possess the necessary genes to replicate DNA.

Previous research has described at least some of the fundamental processes involved in healthy, on - going peripheral nerve growth regeneration, including the critical role of mitochondria — cellular organelles that produce adenosine triphosphate (ATP), the energy - carrying molecule found in all cells that is vital to driving nerve recovery after injury.

This energy — in the form of adenosine triphosphate (ATP)-- is provided by mitochondria, the cell's internal power plants.

Nyce's group created a single strand of DNA whose amino acids complement those in the messenger RNA that helps make adenosine receptors.

The Escherichia coli methyl - directed reaction has been reconstituted in a purified system consisting of MutH, MutL, and MutS proteins, DNA helicase II, single - strand DNA binding protein, DNA polymerase III holoenzyme, exonuclease I, DNA ligase, along with ATP (adenosine triphosphate), and the four deoxynucleoside triphosphates.

A suspected trigger for this constriction is adenosine, a chemical messenger found in high amounts in the lung fluid of asthmatics, says Jonathan Nyce, a molecular pharmacologist at EpiGenesis Pharmaceuticals in Greenville, North Carolina.

ADA addition resulted in adenosine degradation leading to a reduction of regulatory T - cell mediated suppression.