Sentences with phrase «of adenoviral»

Despite the marginal improvements in survival of patients suffering from malignant glioma treated with gene therapy vectors, the clinical trials conducted so far using viral vectors, in particular adenoviral vectors, have proven that the use of adenoviral vectors is a safe therapeutic approach, even in large, multicenter, phase 3 clinical trials.

Preparation and distribution of 19 reference antigens for several diseases including malaria, HIV and tuberculosis, and the establishment of five new cell banks to improve the growth of adenoviral vectors.

The complete genome of TMAdV was found to be 36,842 base pairs in length, with a base composition of 20.8 % A, 29.8 % C, 29.8 % G, and 19.6 % T, and a GC content of 59.6 %, comparable to that of adenoviral species Groups C, D, and E in the Mastadenovirus genus.

Fourth, the finding of intranuclear inclusions in diseased tissues, as well as direct visualization of adenoviral - like particles (TMAdV) in lung alveoli by electron microscopy (Figs. 1D - 2 to 1D - 4), support a primary role for TMAdV in the pathogenesis of tissue injury in affected monkeys.

Not exact matches

VETERINARY health company Imugene has been granted a key patent in Japan for the product that is the basis of its poultry vaccines.Called the Fowl Adenoviral Delivery Vector, the product is a componen

Perth biotechnology company Imugene Ltd has received notice of grant for patent protection for its Porcine Adenoviral Delivery Vector technology in the United States of America, the company has announced.

To confirm the accuracy of the coding sequence, the sequence of each identified ORF was aligned to a database containing all adenoviral proteins in GenBank by BLASTX.

The high degree of sequence relatedness within members of each species suggests that at least some adenoviral strains may be capable of infecting both nonhuman primates and humans.

However, the high sequence divergence in the fiber protein (Table 2), as well as the absence of fiber motifs conserved among adenoviruses that bind CAR [36], [37](coxsackievirus - adenovirus receptor) or CD46 [38], [39], [40](data not shown), suggest that neither of these two human adenoviral receptors may be the attachment receptor for TMAdV.

The closest human adenoviral relatives were the species D adenoviruses, which share 54.3 % to 55.1 % identity to TMAdV, with human adenoviruses of other species slightly less similar (51.1 % — 54.6 %).

With the exception of SAdV - 23, these highly conserved probes are part of the core Virochip design and were derived from all available adenoviral sequences in GenBank as of 2002 [21].

Second, the clinical presentation of pneumonia and hepatitis is consistent with the known spectrum of disease associated with adenoviral infections.

In PNP's Phase I trial, an adenoviral vector is used to deliver E. coli PNP to head and neck tumors followed by intravenous administration of the prodrug fludarabine.

In the current work we used adenoviral - type 5 (dE1 / E3)(Cytomegalovirus promoter) with human ABCA10 transgene (Ad - h - ABCA10) purchased from Vector Labs ® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin.

Svensson, Eric et al. «Long - term erythropoietin expression in rodents and non-human primates following intramuscular injection of a replication - defective adenoviral vector.»

Additionally, the adenoviral generation of the iPSCs did not lead to any teratomas or other abnormalities suggesting that they are safe for this type of use.

In animal models, E1 - deleted human adenoviral recombinants of the serotype 5 (AdHu5) have shown high efficacy as vaccine carriers.

To circumvent this problem, novel replication - defective adenoviral vaccine carriers based on El - deleted recombinants of chimpanzee - derived adenoviruses were developed.

This research, funded by NIH, aims to test adenoviral recombinants based on simian serotypes for induction of immune responses to gag / pol / rev of HIV - 1 or SIV - 1 in a mouse model.

Lack of preexisting virus - neutralizing antibodies in the human population suggests that these novel adenoviral recombinants may provide improved vaccine carriers for use in humans.

The InterPlay Adenoviral TAP System combines our unique tandem affinity purification (TAP) system with our exclusive adenoviral gene delivery system, the AdEasy Adenoviral Vector System, for enhanced gene delivery to a broader range of mam... ReAdenoviral TAP System combines our unique tandem affinity purification (TAP) system with our exclusive adenoviral gene delivery system, the AdEasy Adenoviral Vector System, for enhanced gene delivery to a broader range of mam... Readenoviral gene delivery system, the AdEasy Adenoviral Vector System, for enhanced gene delivery to a broader range of mam... ReAdenoviral Vector System, for enhanced gene delivery to a broader range of mam... Read more...

The gene - targeting approach developed by Suzuki and his colleagues relies on the use of so - called helper - dependent adenoviral vector to deliver large mutation - free DNA molecules into cells.

A featured paper in the February issue of the research journal Cancer Gene Therapy demonstrates that cancer cells in the liver are excellent targets for gene therapy using adenoviral vectors, based upon a fundamental new understanding of the differences between cancerous and normal liver cells.

«At that time, I was treating patients with colon cancer that had spread to the liver using a very similar adenoviral vector administered in exactly the same way — direct infusion into the main artery feeding the liver,» said Reid, who is now an associate professor of clinical medicine in the UCSD School of Medicine.

Under the mentorship of Drs. Richard L. Hurwitz and Catherine M. Bollard, he characterized the immune response against an adenoviral vector delivered intravitreally in retinoblastoma patients.

2/13/2007 Study Shows Liver an Excellent Target For Cancer Gene Therapy Using Viral Vectors A featured paper in the February issue of the research journal Cancer Gene Therapy demonstrates that cancer cells in the liver are excellent targets for gene therapy using adenoviral vectors, based upon a fundamental new understanding of the differen... More...

The disorganized structure of the cancer cells exposes the receptors so that Onyx - 015, the adenoviral vectors used in this study, can readily enter tumor cells.

Adenoviral vectors can be produced by human embryonic kidney (HEK293) and human embryonic retinal (PER.C6) cell lines (31), both of which also can be used for lentiviral vector production.

It is also important to realize that studying a truly systemic LPL — KO mouse is difficult, as 97 % of the mice die shortly (15 days) after birth, unless they receive adenoviral rescue of LPL expression in the heart, in which case the animals have residual post-heparin LPL activity (31).

Adenovirus was produced by transfecting adenoviral expression vector into E1 - complemented cell line 293A and performing successive rounds of amplification until high titer was achieved.

In separate experiments, an adenoviral construct inhibiting IKKβ, an upstream component of the nuclear factor kappa - b (NFkB) pathway, was a priori injected into the NAc.