Sentences with phrase «of adenovirus»

Characterization of the nucleic acid binding region of adenovirus DNA binding protein by partial proteolysis and photochemical cross-linking

Isolation and analysis of adenovirus type 5 mutants containing deletions in the gene encoding the DNA - binding protein

Barroso spent his first year at GSK's Biopharmaceuticals Centre of Excellence for Drug Discovery near London looking at the use of adenoviruses in gene - transfer therapy.

Until now the use of adenoviruses in tumor therapy has been very limited.

Such serotypes of adenovirus do not circulate in the human population.

Such antibodies are expected to reduce the efficacy of vaccines based on common human serotypes of adenovirus in a human target population.

Review of «Intrastriatal Transplantation of Adenovirus - Generated Induced Pluripotent Stem Cells for Treating Neuropathological and Functional Deficits in a Rodent Model of Huntington's Disease» from Stem Cell Translational Medicine by Stuart P. Atkinson.

Special strains of the adenovirus, the researchers say, have been altered to deploy anticancer genes within tumors, killing cancer cells while leaving healthy ones unscathed.

Now, a new report confirms that the Davis outbreak was the first known case of an adenovirus jumping from monkeys to humans.

We used the Virochip, a microarray designed to detect all viruses, to identify a new species of adenovirus (TMAdV, or titi monkey adenovirus) that caused a deadly outbreak in a colony of New World titi monkeys at the California National Primate Research Center (CNPRC), and also infected a human researcher.

In addition, phylogenetic analyses of adenoviruses from greater apes reveal that they fall precisely into «human» adenoviral species B, C, and E [7].

We initially used consensus primers derived from a highly conserved region of the hexon gene to confirm the Virochip finding of an adenovirus by PCR [25].

Mutations that affect phosphorylation of the adenovirus DNA - binding protein alter its ability to enhance its own synthesis

In addition, the genome of the adenovirus is very large and does not integrate into human chromosomes.

The numerous advantages of adenoviruses will likely help to tackle one of the greatest problems of cancer medicine: The development of resistances against drugs.

Genetic material is found in the core of each adenovirus (shown in green) and is surrounded by a protein coat (the red part).

«There is no question that the efficiency of the adenovirus is much better,» says Williamson, «but there is also no question that everyone would rather get away from (using a) virus strategy if they could.»

To the team's surprise, a single shot of the adenovirus proved to be enough: after 28 days, eight monkeys survived doses of the virus that killed two unprotected animals.

Merck has initiated a proof - of - concept phase IIb clinical trial to study the effectiveness of its adenovirus - based vaccine, along with subjects» resistance to infection by the relatively common adenovirus — a potential drawback to the vaccine.

The paper describes two new studies in which investigators evaluated the protective efficacy of an adenovirus serotype 26 (Ad26) vectored vaccine boosted with a purified envelope protein.

Therefore, Jensen - Jarolim and her team used parts of adenoviruses, so - called adeno - associated viral particles (AAV particles) as carriers.

When you get the sniffles, your immune system detects the invasion of an adenovirus or other cold - causing pathogen and counterattacks.

Neither the lab worker nor her family members sought medical attention, and all recovered within 4 weeks, after which it was too late for researchers to swab for traces of the adenoviruses directly.

Entry of adenoviruses into cells involves an initial attachment of the fiber knob to the cell receptor, followed by internalization via a secondary interaction of the penton base with αv integrins [34], [35].

In nonhuman primates, most epidemiologic studies of adenoviruses have focused on their identification in fecal samples from asymptomatic animals [6], [7], [8].

To confirm the presence of virus in diseased tissues, we examined lung tissue from affected monkeys by transmission electron microscopy, revealing abundant icosahedral particles characteristic of adenovirus filling the alveoli (Fig. 1D - 4).

While there, I developed a class of adenovirus vectors known as «gutted» or helper - dependent Ad.

Scientists have uncovered variations in the surface structures of adenovirus species that may help us develop better gene delivery tools

Cis - acting elements and a trans - acting factor affecting alternative splicing of adenovirus L1 transcripts

Similar regulation of the synthesis of adenovirus fiber and of simian virus 40 - specific proteins encoded by the helper - defective Ad2 + SV40 hybrid viruses Ad2 + ND5 and Ad2 + ND4del

Characterization of adenovirus type 5 insertion and deletion mutants encoding altered DNA binding proteins

Nuclear localization of the adenovirus DNA - binding protein: Requirement for two signals and complementation during viral infection

Proteins containing only half of the coding information of early region 1b of adenovirus are functional in human cells transformed with the herpes simplex virus type 1 thymidine kinase gene and adenovirus type 2 DNA

Recently, inactivated forms of the adenovirus have been used as vaccine - delivery vehicles, due to their well - known structure, which makes them easier for scientists to modify.

Multiple Functions of the Adenovirus DNA - Binding Protein Are Required for Efficient Viral DNA Synthesis

Independent, spontaneous mutants of adenovirus type 2 - simian virus 40 hybrid Ad2 + ND3 that grow efficiently in monkey cells possess indentical mutations in the adenovirus type 2 DNA - binding protein gene

As a specific disease, Infectious Canine Hepatitis (ICH) is a viral infection caused by a member of the Adenovirus family.

Dr. Dodds believes that with the appearance of adenovirus 1 in the Maritimes, if you live in or visit the New England area and your dog could be exposed to potentially infected wildlife, you can add CAV - 2 vaccines — two doses for puppies, and then re-vaccinate adult dogs as needed based on hepatitis titers.

This immediately caused a huge panic because of the virulence of the adenovirus 1 strain.

Intrastriatal Transplantation of Adenovirus - Generated Induced Pluripotent Stem Cells for Treating Neuropathological and Functional Deficits in a Rodent Model of Huntington's Disease» from Stem Cell Translational Medicine by Stuart P. Atkinson.

A possible problem facing a human vaccine is that some people already have an immune response to some strains of adenoviruses, which would reduce the body's response to the vaccine strain.

Now, I've never even seen a case of adenovirus in my practice, so I asked Dr. Dodds to help us understand what's going on.

To confirm the Virochip finding of an adenovirus, we used consensus primers to amplify a 301 bp fragment from the hexon gene by PCR [25].

Phosphorylation of the Adenovirus DNA - Binding Protein and Epitope Mapping of Monoclonal Antibodies against It

Researchers at first blamed the failure on the use of adenovirus 5 as the carrier for three HIV genes designed to stimulate immunity to HIV.