Sentences with phrase «of adjuvant therapy»

«In an era of increasing use of minimally invasive surgery that enables administration of adjuvant therapy more reliably,» says Dr. Yendamuri, «the paradigm of routine neoadjuvant therapy for patients with this stage of disease should be reconsidered.»

The degree of involvement of regional lymph nodes is predictive of overall survival and is also a key factor in determining the appropriateness of adjuvant therapy and the patient's eligibility for investigational trials.

Not exact matches

The research also found adjuvant therapy did not increase rates of erectile dysfunction.

«Urologists tend to prefer to forgo adjuvant radiation therapy, because they fear the side effects, and radiation oncologists tend to prefer offering adjuvant radiation therapy because they fear the risk of metastasis [cancer spreading to other sites in the body],» Showalter said.

Some adjuvants have been tested as therapy in and of themselves, but they have rarely proved effective and have usually been shelved.

Furthermore, older patients are at risk from the adverse side - effects of adjuvant treatments such as hormone therapy or chemotherapy.

As reported in 2015, the study met its primary endpoint after a median follow up of 2.3 years, with ipilimumab significantly improving recurrence - free survival.2 The drug was subsequently approved by the US Food and Drug Administration as adjuvant therapy for stage III melanoma.

The HOPE study looked at the effect of exercise on body weight, body fat, and inflammatory biomarkers in 121 women with joint pain from taking aromatase inhibitors (AI) as adjuvant therapy.

«By understanding how stress accelerates invasion in aggressive breast tumor cells, this work will inform future studies into whether beta - blockers could be a useful adjuvant therapy in the treatment of some aggressive breast cancers.»

Trial # 1: A phase I / II trial of HCQ in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

«We have identified a subgroup of older patients at sufficiently low risk of recurrence for whom omission of postoperative radiotherapy after breast - conserving surgery and adjuvant endocrine therapy is a reasonable option.

«Standard first line treatment consists of surgical resection followed by radiation and concomitant and adjuvant temozolomide therapy.

His laboratory at the German Cancer Research Center in Heidelberg and at the Medical Faculty Mannheim of Heidelberg University is studying the mechanisms of metastasis with the goal to develop more gentle supportive adjuvant therapies for tumor patients without detectable metastases following surgery of the primary tumor.

Based on these results, two phase 3 trials are being planned for platinum - sensitive and platinum - resistant ovarian cancer patients by one of NCI's new National Cancer Trial Network Groups, the NRG Oncology Group (formerly 3 cooperative groups: the National Surgical Adjuvant Breast and Bowel Project (NSABP), the Radiation Therapy Oncology Group (RTOG), and the Gynecologic Oncology Group (GOG).

Helmut Oettle, M.D., Ph.D., of the Charite - Universitatsmedizin Berlin, Germany, and colleagues conducted follow - up of a randomized trial that previously reported improvement in disease - free survival with adjuvant (in addition to surgery) gemcitabine therapy to determine if this treatment improved overall survival.

Interferon alfa - 2b adjuvant therapy of high - risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684.

The Use of Antimicrobials as Adjuvant Therapy for the Treatment of Obesity and Insulin Resistance: Effects and Associated Mechanisms — Sandra Aparecida dos Reis — Diabetes / Metabolism Research and Reviews

Letrozole is approved by the FDA for the adjuvant treatment of early - stage breast cancer in postmenopausal women who have already been treated with 5 years of tamoxifen therapy.

PALLAS: Palbociclib Collaborative Adjuvant Study: A Randomized Phase III Trial of Palbociclib with Standard Adjuvant Endocrine Therapy versus Standard Adjuvant Endocrine Therapy Alone for Hormone Receptor Positive (HR +) / Human Epidermal Growth Factor Receptor 2 (HER2)- Negative Early Breast Cancer

Phase III Randomized, Placebo - Controlled Clinical Trial Evaluating the Use of Adjuvant Endocrine Therapy + / - One Year of Everolimus in Patients with High - Risk, Hormone Receptor - Positive and HER2 / neu Negative Breast Cancer.

The adjuvant therapy program offered through our Breast Center closely monitors each patient's condition throughout every step of her treatment — transforming her from someone who may have become a victim, to a survivor.

A Phase III, Multicenter, Randomized, Placebo - Controlled, Double - Blind Study Of Atezolizumab (Anti − PD - L1 Antibody) As Adjuvant Therapy In Patients With Renal Cell Carcinoma At High Risk Of Developing Metastasis Following Nephrectomy

A Randomized, Phase III Trial to Evaluate The Efficacy and Safety of MK - 3475 (Pembrolizumab) as Adjuvant Therapy for Triple Receptor - Negative Breast Cancer with ≥ 1 cm Residual Invasive Cancer or Positive Lymph Nodes (yPN +) After Neoadjuvant Chemotherapy

Currently, lymphadenectomy is an eligibility requirement for cutting - edge adjuvant therapy trials such as Southwest Oncology Group (SWOG) 1404 (ClinicalTrials.gov identifier: NCT02506153), which randomizes stage III melanoma patients to an anti — programmed death 1 antibody or standard - of - care adjuvant therapy (high - dose interferon or high - dose ipilimumab).

SEATTLE, Feb. 05, 2018 (GLOBE NEWSWIRE)-- NanoString Technologies, Inc. (NASDAQ: NSTG), a provider of life science tools for translational research and molecular diagnostic products, today announced the publication of a landmark study in which Danish researchers used the Prosigna ® Breast Cancer Assay risk of recurrence (ROR) score to accurately predict rates of 10 - year distant recurrence (DR) of cancer in a comprehensive and population - based cohort including all postmenopausal women in Denmark with early - stage hormone receptor (HR)- positive, Her - 2 negative breast cancer who received 5 years of adjuvant endocrine therapy according to nationwide guidelines between 2000 and 2003.

For example, adjuvant therapies that inhibit this type of cell plasticity may be a very effective way to keep metastasis at bay.»

There was no difference in lactate dehydrogenase, the number of metastatic sites, prior adjuvant therapy, primary in place at initiation of therapy, or intent of treatment across the cohorts for right - compared with left - sided tumors.

The role of adjuvant systemic therapy in patients with mucosal melanoma following definitive therapy is not clear.

Following surgery, adjuvant therapy will consist of up to 12 months of atezolizumab in participants who demonstrate clinical benefit with neoadjuvant therapy.

Important reports from the Weiner lab include the first DNA vaccine studied for HIV as well as for cancer immune therapy of cutaneous T cell lymphoma, the early development of DNA encoded genetic adjuvants, including IL - 12, advances in gene optimization, and advances in electroporation technologies resulting in improved gene delivery.

Inclusion Criteria: • The participant may have no more than 2 prior lines of systemic therapies (neoadjuvant and adjuvant therapies will not be considered as a prior line of therapy) for advanced or metastatic disease and is suitable to receive gemcitabine and docetaxel therapy.

February 2, 2017 Under and misuse of hormone therapy decreasing, but still high A nationwide cancer registry of almost one million patients treated for hormone - sensitive breast cancer shows that one out of six women who should have received post-surgical treatment known as adjuvant endocrine therapy did not get this recommended component of care, which can reduce the odds of recurrence.

Mature results of a phase III randomized trial of bacillus Calmette - Guerin (BCG) versus observation and BCG plus dacarbazine versus BCG in the adjuvant therapy of American Joint Committee on Cancer stage I - III melanoma (E1673).

Chaired by Prof. Dirk Schadendorf, talks covered topics which included: melanoma epidemiology in the in period since the start of the German National Skin Cancer screening programme (Dr Andreas Strang); an overview of melanoma therapies used in stage IV melanoma; adjuvant therapies and prognosis in stage III melanoma (Dr Lisa Zimmer); tumour heterogeneity, plasticity and resistance in melanoma (Alexander Roesch); epigenomics of normal and abnormal cell differentiation (Bernard Horsthermeke); and, genetics and epigenetics of uveal melanoma (Michael Zeschnigk).

A phase I / II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme.

Whereas, a phase I / II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme led to no significant improvement in overall survival, which could be due to inconsistent autophagy inhibition in patients treated with this regimen [29].

But a type of therapy called cognitive behavioral therapy (CBT)-- which focuses on changing behavior, rather than talking about your childhood, for instance — can be an effective adjuvant to or even substitute for drugs.

But the authors of the new study do link stress - reduction techniques with improved immunity: «Added immune control of disease processes, particularly early — when patients were recovering from surgery and receiving adjuvant cancer therapies — may have occurred with the declining stress.»

A 2015 article in the International Journal of Biochemistry and Cell Biology sums up the findings of multiple studies on ketogenic diets and cancer with the following: «there is increasing evidence that the ketogenic diet may also be beneficial as an adjuvant cancer therapy by potentiating the antitumor effect of chemotherapy and radiation treatment.»

Gerbin and co-researchers at the Institute of cell biology in Switzerland found creatine could be used successfully as an adjuvant therapy for bone fracture healing or for the treatment of osteoporosis 7.

Indications for radiation therapy (RT) include the primary treatment of specific tumor types, such as nasal tumors and brain tumors, adjuvant treatment of incompletely excised tumors, and palliation to improve quality of life for patients with non-resectable or advanced cancers.

Adjuvant chemotherapy (after surgery or radiation therapy) may help to prevent or delay the onset of metastases.

Conventional standard therapy for canine appendicular OSA includes amputation of the affected limb, and administration of adjuvant chemotherapy.

There is currently limited information regarding the effect of adjuvant radiation therapy in dogs with axial osteosarcomas.

There has been a substantial increase in the use of temporary androgen suppression therapy (AST) as an adjuvant management of prostate cancer.