Sentences with phrase «of adverse effects with»

If it is decided to use antidepressant therapy, the selection of the antidepressant should be based on the mother's prior response and experience of adverse effects with a particular agent, risk of interactions with concurrent medications and published adverse effects associated with a particular agent on breastfeeding mothers and their infants.

If you suffer from trimethylaminuria, renal disease, liver disease, depression or Parkinson's disease, you might be at risk of adverse effects with choline intakes.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

If you're struggling with any of the adverse side effects of goal setting outlined above, try a new strategy.

The Healthcare Reform Law, including The Patient Protection and Affordable Care Act and The Healthcare and Education Reconciliation Act of 2010, could have a material adverse effect on Humana's results of operations, including restricting revenue, enrollment and premium growth in certain products and market segments, restricting the company's ability to expand into new markets, increasing the company's medical and operating costs by, among other things, requiring a minimum benefit ratio on insured products, lowering the company's Medicare payment rates and increasing the company's expenses associated with a non-deductible health insurance industry fee and other assessments; the company's financial position, including the company's ability to maintain the value of its goodwill; and the company's cash flows.

As lawyer and legal scholar Scott Killingsworth argues, «command - and - control» approaches to compliance come with a number of inherent limitations and adverse side effects.

The discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations.

Legalistic, command - and - control messaging is discussed and its inherent limitations and adverse side effects are contrasted with the virtues of ethical or values - based messaging.

These risks and uncertainties include competition and other economic conditions including fragmentation of the media landscape and competition from other media alternatives; changes in advertising demand, circulation levels and audience shares; the Company's ability to develop and grow its online businesses; the Company's reliance on revenue from printing and distributing third - party publications; changes in newsprint prices; macroeconomic trends and conditions; the Company's ability to adapt to technological changes; the Company's ability to realize benefits or synergies from acquisitions or divestitures or to operate its businesses effectively following acquisitions or divestitures; the Company's success in implementing expense mitigation efforts; the Company's reliance on third - party vendors for various services; adverse results from litigation, governmental investigations or tax - related proceedings or audits; the Company's ability to attract and retain employees; the Company's ability to satisfy pension and other postretirement employee benefit obligations; changes in accounting standards; the effect of labor strikes, lockouts and labor negotiations; regulatory and judicial rulings; the Company's indebtedness and ability to comply with debt covenants applicable to its debt facilities; the Company's ability to satisfy future capital and liquidity requirements; the Company's ability to access the credit and capital markets at the times and in the amounts needed and on acceptable terms; and other events beyond the Company's control that may result in unexpected adverse operating results.

For example, the expected timing and likelihood of completion of the proposed merger, including the timing, receipt and terms and conditions of any required governmental and regulatory approvals of the proposed merger that could reduce anticipated benefits or cause the parties to abandon the transaction, the ability to successfully integrate the businesses, the occurrence of any event, change or other circumstances that could give rise to the termination of the merger agreement, the possibility that Kraft shareholders may not approve the merger agreement, the risk that the parties may not be able to satisfy the conditions to the proposed transaction in a timely manner or at all, risks related to disruption of management time from ongoing business operations due to the proposed transaction, the risk that any announcements relating to the proposed transaction could have adverse effects on the market price of Kraft's common stock, and the risk that the proposed transaction and its announcement could have an adverse effect on the ability of Kraft and Heinz to retain customers and retain and hire key personnel and maintain relationships with their suppliers and customers and on their operating results and businesses generally, problems may arise in successfully integrating the businesses of the companies, which may result in the combined company not operating as effectively and efficiently as expected, the combined company may be unable to achieve cost - cutting synergies or it may take longer than expected to achieve those synergies, and other factors.

The Enterprise Compensation Committee discharges the board of directors» responsibilities relating to the compensation of our executives and directors; reviews and discusses with management the Compensation Discussion and Analysis and performs other reviews and analyses and makes additional disclosures as required of compensation committees by the rules of the SEC or applicable exchange listing requirements; provides general oversight of our compensation structure, including our equity compensation plans and benefits programs, and confirms that these plans and programs do not encourage risk taking that is reasonably likely to have a material adverse effect on Hewlett Packard Enterprise; reviews and provides guidance on our human resources programs; and retains and approves the retention terms of the Enterprise Compensation Committee's independent compensation consultants and other independent compensation experts.

There are no areas of life unaffected by the substantialist view, with adverse effects.

From the days of his youth he had met with a form of Christian apologetic which could be nothing if not ineffective and which could only have adverse effects upon him, because it was uninformed and proceeded from unexamined presuppositions.

... one front of mission can not be neglected or denied without adverse effect on other fronts; and already the domestic agencies of the churches are being afflicted with blight and malnutrition.

I thank Michael Knower for his insightful «on - the - ground» report as a palliative care physician in Oregon, which affords him firsthand experience with the adverse effects of the law permitting assisted suicide.

I always bake them, and I use half the amount of oil listed with no adverse effects.

But by making your own protein - powered, coffee - free lattes at home, you'll get all the deliciousness and energy with none of the adverse effects.

You need to rinse your body very thoroughly though, since the ground coffee will stick to your body like the devil, but since the coffee will be flushed out of the tub / shower with PLENTY of water (for above mentioned reason), I haven't been able to see any adverse effects on the plumbing yet.

When inflammation strikes, we are conditioned into reaching for a quick fix in the way of pharmaceutical or prescribed drugs such as aspirin and ibuprofen, temporary panacea's that come with their own adverse side effects and with long term use have the potential to create a host of health problems independently.

It relies on ecological processes, biodiversity and cycles adapted to local conditions, rather than the use of inputs with adverse effects.

It relies on ecological processes, biodiversity and cycles adapted to local conditions, rather thanthe use of inputs with adverse effects.

That means Food Toxicology deals with the study of substance found in the food that cause adverse effect to the body when it is consumed by the large quantities.

It relies on ecological processes, biodiversity and nutrients, energy and water cycles adapted to local conditions, rather than on the use of external inputs with adverse effects.

Nicholas believes that the influence of Alexis Sanchez since his January move from Arsenal has had an adverse effect on the team, particularly with regards to Romelu Lukaku as it changes the way in which Man Utd play.

With Inter continuing to battle for a Champions League spot this season, it remains to be seen if failure to book a place at Europe's top table has an adverse effect on their ability to keep him at the San Siro, but according to Calciomercato the fear of losing him is growing.

I don't want to be misconstrued here; I will wholeheartedly welcome a new striker who will give us another 6 - 12 PL goals, and our overall chances of winning the league will undoubtedly increase (assuming of course, all things being equal, there are no adverse effects to the team overall with a new face scoring more goals — weakening us defensively, not linking as well with others, dressing room morale etc).

After all, having spent 98 days in administration (the equivalent of footballing bankruptcy), the footballing factory of England was only heading downwards with points deductions as well downsizing due to have an adverse effect.

So, whereas I was of the opinion that heading into Monday's encounter no longer top of the league would have a negative effect on the team, it will instead empower them with so much reassurance and positivity that any sort of result would be enough to keep them on course for the title, but it does also mean they're there to be shot at so don't be at all surprised if United come sprinting out of the blocks this evening and put the Gunners to the sword very early on as don't forget, United had top - spot stolen away from them because of the recent bout of adverse weather.

In addition to the tiredness, any jet lag associated with the lot of travelling in order to get back to New Zealand may cause adverse effects to the players in these two matches, according to Hudson.

Chemicals with estrogenic activity «have been reported to have potential adverse health effects in mammals, including humans, especially in fetal and infant states,» says Dr. George Bittner, a professor of neurobiology at the University of Texas at Austin who has served on many National Institutes of Health panels.

EFSA Limits 3 - MCPD Concentration Levels Due to the growing concern over the potential adverse health effects associated with 3 - monochloropropanediol (3 - MCPD), the European Food Safety Authority (EFSA) has limited concentration levels of this chemical byproduct in certain foods like hydrolyzed vegetable proteins.

J Shaped - Premium Contoured Body Pregnancy Maternity Pillow comes up with back and belly protection to neutralize adverse effects of sleeping troubles.

Sunday After a rather late night, I was up early Sunday morning to sit in on a special Hot Topic session with Dr. Isabelle Fox, who spoke on divorce, custody, and child development with emphasis on the adverse effects of overnight visitations with infants and toddlers.

Mass Audubon does not interfere with the natural water regime of wetlands on our properties to control mosquitoes, because of the significant adverse effects on wildlife and the natural system as a whole.

Previous research has shown the adverse health effects associated with suboptimal breastfeeding cost the United States $ 14.2 billion annually (2011 dollars) in pediatric disease, including the costs of 911 child deaths.4

FDA: «FDA Drug Safety Communication: Reports of a rare, but serious and potentially fatal adverse effect with the use of OTC benzocaine gels and liquids applied to the gums or mouth.»

Tests showed that people allergic to regular strawberries could eat or handle white strawberries with little in the way of adverse effects.

Twenty - nine percent of children 2 to 3 years of age have a television in their bedroom, and 30 % of parents have reported that watching a television program enabled their children to fall asleep.3 Although parents perceive a televised program to be a calming sleep aid, some programs actually increase bedtime resistance, delay the onset of sleep, cause anxiety about falling asleep, and shorten sleep duration.41 Specifically, in children younger than 3 years, television viewing is associated with irregular sleep schedules.42 Poor sleep habits have adverse effects on mood, behavior, and learning.

These questions pertained to the length of time they breastfed, use of any medications and / or tobacco during the period they breastfed, whether they supplemented with formula feedings, and whether they had noted any adverse effects in their infants while breastfeeding or after weaning.

In his study «The Nutritive Value of Strained Vegetables in Infant Feeding,» George W. Caldwell, MD, noting on the first page that «the vegetables used in this investigation were furnished through the courtesy of the Gerber Products Company, Fremont, Michigan,» concluded that infants fed vegetables are healthier, with no adverse side effects.

There are now 400 reports of adverse side effects — including 10 deaths — associated with these products, according to the FDA.

Once I was done with my research, and you are welcome to read my paper on it here, I concluded that sleep training done right doesn't have any adverse effects but leads to a host of positive ones.

FDA Drug Safety Communication: Reports of a rare, but serious and potentially fatal adverse effect with the use of over-the-counter (OTC) benzocaine gels and liquids applied to the gums or mouth.

These findings are all consistent with the growing body of literature on the impact of adverse childhood experiences on neurological, cognitive, emotional and social development, as well as physical health.38 Although some studies have found no relation between physical punishment and negative outcomes, 35 and others have found the relation to be moderated by other factors, 12 no study has found physical punishment to have a long - term positive effect, and most studies have found negative effects.17

Tough documents the devastating effects of adverse childhood experiences on children's ability to cope with stress, and he reports on recent educational programs to help students develop «non-cognitive» skills - grit, optimism, curiosity, zest, social intelligence, gratitude, and self - control — that are essential to success in life.

Note that the U.S. Surgeon General is vigorously promoting breastfeeding, while saying nothing about the possibility of adverse effects associated with breastfeeding.

The news is both favorable and reassuring: «Only a small proportion of medications are contraindicated in breastfeeding mothers or associated with adverse effects on their infants.»

He said, «The incessant breaching and vandalisation of pipelines and oil theft have taken direct tolls on oil production and supplies with corresponding adverse effects on the economy of our country.

An increase in the child element of the child tax credit by a further # 30 in 2011 - 12 and # 50 in 2012 - 13 above inflation will ensure low income families with children would be protected from the «adverse effect from these essential savings», he said.