Sentences with phrase «of adverse outcomes at»

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

One must ask then how it is that if Protestant leaders in higher education generally made the right — or at least virtually inevitable — decisions, what has gone wrong that the outcome should be so adverse to the apparent interests of Protestant Christianity?

Explain that if they plan birth at home there is a small increase in the risk of an adverse outcome for the baby.

Women who planned a home birth were at reduced risk of all obstetric interventions assessed and were at similar or reduced risk of adverse maternal outcomes compared with women who planned to give birth in hospital accompanied by a midwife or physician.

For healthy nulliparous women with a low risk pregnancy, the risk of an adverse perinatal outcome seems to be higher for planned births at home, and the intrapartum transfer rate is high in all settings other than an obstetric unit

For nulliparous women, there is some evidence that planning birth at home is associated with a higher risk of an adverse perinatal outcome.

The strengths of the study include the ability to compare outcomes by the woman's planned place of birth at the start of care in labour, the high participation of midwifery units and trusts in England, the large sample size and statistical power to detect clinically important differences in adverse perinatal outcomes, the minimisation of selection bias through achievement of a high response rate and absence of self selection bias due to non-consent, the ability to compare groups that were similar in terms of identified clinical risk (according to current clinical guidelines) and to further increase the comparability of the groups by conducting an additional analysis restricted to women with no complicating conditions identified at the start of care in labour, and the ability to control for several important potential confounders.

Labor induction has been increasing since the early 1990s, 1 and the rate is running at about 20 % for pregnancies at term.2, 3 Induction of labor compared with spontaneous labor is associated with adverse maternal outcomes, including at least a doubling in the caesarean delivery rate, 4,5 25 — 50 % increase in instrumental vaginal delivery rate, 3,5 higher postpartum hemorrhage rate, 5 and prolonged labor.5 Neonates born after induced labor are more likely to have low Apgar score and low umbilical cord blood pH. 5

Planned birth at home in low risk women without complicating conditions at the start of care in labour was associated with significant cost savings and a significant decrease in adverse perinatal outcomes avoided.

There was, however, an increased incidence of adverse perinatal outcome associated with planned birth at home in nulliparous low risk women, resulting in the probability of it being the most cost effective option at a cost effectiveness threshold of # 20000 declining to 0.63.

We used multiple regression to estimate the differences in total cost between the settings for birth and to adjust for potential confounders, including maternal age, parity, ethnicity, understanding of English, marital status, BMI, index of multiple deprivation score, parity, and gestational age at birth, which could each be associated with planned place of birth and with adverse outcomes.12 For the generalised linear model on costs, we selected a γ distribution and identity link function in preference to alternative distributional forms and link functions on the basis of its low Akaike's information criterion (AIC) statistic.

In further analyses restricted to women without complicating conditions at the start of care in labour, the adjusted odds of adverse perinatal outcomes were higher for births planned at home compared with those planned in obstetric units (adjusted odds ratio 1.59, 95 % confidence interval 1.01 to 2.52).

There was, however, an increased incidence of adverse perinatal outcomes associated with planned birth at home in nulliparous low risk women, resulting in the probability of it being the most cost effective option at a threshold of # 20000 declining to 0.63.

This review suggests that women who received midwife - led continuity models of care were less likely to experience intervention and more likely to be satisfied with their care with at least comparable adverse outcomes for women or their infants than women who received other models of care.

A comparison of adverse neonatal outcomes did not identify increased risk for babies born at home as part of the HBDP.

When we restricted the home - birth group to women who actually gave birth at home, the rates of adverse maternal and newborn outcomes did not differ significantly from those among all planned home births.

Poor nutrition during these critical growth and developmental periods places infants and children at risk of impaired emotional and cognitive development and adverse health outcomes.

«Our research indicates that insertion of cervical pessary at around 22 weeks in both randomly selected women pregnant with twins and in patients with a short cervix of less than 25 millimeters does not reduce the rate of spontaneous early preterm birth, perinatal death, adverse neonatal outcome, or need for neonatal therapy.»

Both adverse outcomes need to be studied further, according to Legro, who led a team that hosted the Chinese collaborators at Penn State College of Medicine for five weeks as the group wrote the protocol for the multi-center trial and participated in regular steering committee meetings overseeing the trial.

«After careful examination of the burden of disease among women aged 40 to 54 years, the guideline development group (GDG) concluded that the lesser, but not insignificant, burden of disease for women aged 40 to 44 years and the higher cumulative risk of adverse outcomes no longer warranted a direct recommendation to begin screening at age 40 years.»

These behaviors predict more serious adverse outcomes later in life, such as substance abuse, delinquency, and violence, explains study leader Anne Riley, PhD, professor in the Department of Population, Family, and Reproductive Health at the Johns Hopkins Bloomberg School of Health.

«It's an exciting development, and we await the outcome over the next year to see how well these cells integrate, and if there are any potential adverse reactions,» says Mike Cheetham of the Institute of Ophthalmology at University College London, one site where research is under way into a human embryonic stem - cell treatment for AMD.

«Mothers of infants with complex congenital heart disease are exposed to increased stress, which has been associated with numerous adverse outcomes,» said Barbara Medoff - Cooper, PhD, RN FAAN, principal investigator and nurse scientist in the Cardiac Center at Children's Hospital of Philadelphia and at Penn Nursing.

In the article, Stamatina Iliodromiti from the University of Glasgow, UK, and colleagues found birth weight less than 25th or greater than 85th centile to be associated with greater risk of adverse outcomes compared with birth weight within these cutoffs, suggesting an expansion of the definition of «fetus at risk» beyond the less than 10th or greater than 90th centile range that is commonly used to trigger surveillance of fetal well - being and / or delivery.

The study, which randomly assigned 1873 HIV - negative pregnant women at three sites in Malawi to receive either strategy, found that the risks of adverse birth outcomes, at 29.9 and 28.8 percent, was similar in the two groups.

«Our findings have broad implications not only for malaria in pregnancy (125 million pregnancies at risk each year), but also for other globally important causes of adverse birth outcomes such as preeclampsia,» says Dr. Kain, who is also Science Director, Tropical Disease Unit at the Toronto General Hospital, UHN.

She suggests that inappropriately designed fitness programs and services put users at increased risk of injury and adverse health outcomes rather than providing them with the tools to build a healthy lifestyle.

«We have animal literature, which shows direct links between exposure and adverse health outcomes, the limited human studies, and the fact that 90 to 100 percent of the population has measurable levels of these compounds in their bodies,» said John Meeker, an assistant professor of environmental health sciences at the University of Michigan School of Public Health and a lead author.

This database will serve as a basis for a future larger study to identify susceptible subpopulations at higher risk of adverse pregnancy outcomes.

«The fact that nearly half of all highest - risk hospitalizations were followed by at least one adverse outcome — either suicide, unintentional injury death, suicide attempt or rehospitalization — argues strongly for developing expanded post-hospital preventive intervention services for these highest - risk soldiers.»

At least one of these adverse outcomes occurred in the year after discharge in 46.3 percent of the highest - risk hospitalizations.

«The results of this study were of particular interest because more than half of the pregnant women with migraine experienced some type of adverse birth outcome, suggesting that these pregnancies should be considered high risk,» said study author Matthew S. Robbins, M.D., director of inpatient services at Montefiore Headache Center, chief of neurology at Jack D. Weiler Hospital of Montefiore, and associate professor of clinical neurology at Albert Einstein College of Medicine.

«Overall, our results suggest a connection between opioid and heroin use and heroin - related adverse outcomes at the population level, implying that frequent nonmedical users of prescription opioids, regardless of race or ethnicity, should be the focus of public health efforts to prevent and mitigate the harms of heroin use.»

«Together, these findings raise the possibility that hippocampal dysfunction in GWI is one of the adverse outcomes of persistently elevated oxidative stress and inflammation at the systemic level,» he added.

There is evidence that rTMS is safe and not associated with any adverse events, but given the variability in technique and outcome reporting that prevented meta - analysis, the evidence for efficacy of rTMS for seizure reduction is still lacking despite reasonable evidence that it is effective at reducing epileptiform discharges.

The objectives of the guidelines for the rational and responsible use of antimicrobials are: - Optimal outcome for male and female patients - Optimal use of antibiotics (range, mode of administration, dose, duration)- Minimizing side effects, such as adverse effects, development of resistance, nosocomial infections, C. difficile infections and costs The basics of the guidelines are evidence, international and national guidelines, the epidemiology of antimicrobial resistance at the USZ and the ex-factory prices of drugs.

Although it is often suggested that children with epilepsy who are benefiting from ketogenic dietary therapy continue this for at least two years, duration of treatment could be shorter in patients with infantile spasms who become seizure - free; one study reported no adverse effect on seizure outcomes and less risk of growth disturbances when treatment was tapered down after 8 months (15).

According to new research published in the Journal of Clinical Endocrinology and Metabolism, the current policy of limiting thyroid tests to women at high risk of thyroid disease overlooks most cases of thyroid disease during pregnancy, and undiagnosed, untreated thyroid disease in pregnancy carries a significant risk of an adverse outcome for both mother and baby.

The best chance of getting a good underwriting outcome will occur when lung cancer was diagnosed at an early stage, like In Situ or Stage I. (Note, it is probable you will receive an adverse rating if you apply too soon after completing cancer treatment.

Children who experience poverty, particularly during early life or for an extended period, are at risk of a host of adverse health and developmental outcomes through their life course.1 Poverty has a profound effect on specific circumstances, such as birth weight, infant mortality, language development, chronic illness, environmental exposure, nutrition, and injury.

Our findings add insight into the pathways linking early childhood adversity to poor adult wellbeing.29 Complementing past work that focused on physical health, 9 our findings provide information about links between ACEs and early childhood outcomes at the intersection of learning, behavior, and health.29 We found that ACEs experienced in early childhood were associated with poor foundational skills, such as language and literacy, that predispose individuals to low educational attainment and adult literacy, both of which are related to poor health.23, 30 — 33 Attention problems, social problems, and aggression were also associated with ACEs and also have the potential to interfere with children's educational experience given known associations between self - regulatory behavior and academic achievement.34, 35 Consistent with the original ACE study and subsequent research, we found that exposure to more ACEs was associated with more adverse outcomes, suggesting a dose — response association.3 — 8 In fact, experiencing ≥ 3 ACEs was associated with below - average performance or problems in every outcome examined.

Bright Futures, the AAP health promotion initiative, provides resources for pediatricians to detect both ACEs and adverse developmental outcomes.36 Programs like Reach Out and Read, in which pediatricians distribute books and model reading, simultaneously promote emergent literacy and parent — child relationships through shared reading.37, 38 However, ACEs can not be addressed in isolation and require collaborative efforts with partners in the education, home visitation, and other social service sectors in synergistic efforts to strengthen families.29 In this way, programs like Help Me Grow39 that create streamlined access to early childhood services for at - risk children can play a critical role in building an integrated system that connects families to needed resources to enhance the development of vulnerable children.

Cannabis use can be a significant contributor to poor mental health, particularly when it begins at a young age.4, 5 The adverse mental health effects of cannabis use in the general population are increasingly recognised, including anxiety, depression, 6 — 8 psychotic disorders, 4, 9 — 12 dependence6, 7, 13 withdrawal14, 15 and cognitive impairment.16, 17 Starting to use cannabis before age 15 is associated with an increased likelihood of developing later psychotic disorders, increased risk of dependence, other drug use, and poor educational and psychosocial outcomes.5

Relative to children with no ACEs, children who experienced ACEs had increased odds of having below - average academic skills including poor literacy skills, as well as attention problems, social problems, and aggression, placing them at significant risk for poor school achievement, which is associated with poor health.23 Our study adds to the growing literature on adverse outcomes associated with ACEs3 — 9,24 — 28 by pointing to ACEs during early childhood as a risk factor for child academic and behavioral problems that have implications for education and health trajectories, as well as achievement gaps and health disparities.

Felitti and colleagues1 first described ACEs and defined it as exposure to psychological, physical or sexual abuse, and household dysfunction including substance abuse (problem drinking / alcoholic and / or street drugs), mental illness, a mother treated violently and criminal behaviour in the household.1 Along with the initial ACE study, other studies have characterised ACEs as neglect, parental separation, loss of family members or friends, long - term financial adversity and witness to violence.2 3 From the original cohort of 9508 American adults, more than half of respondents (52 %) experienced at least one adverse childhood event.1 Since the original cohort, ACE exposures have been investigated globally revealing comparable prevalence to the original cohort.4 5 More recently in 2014, a survey of 4000 American children found that 60.8 % of children had at least one form of direct experience of violence, crime or abuse.6 The ACE study precipitated interest in the health conditions of adults maltreated as children as it revealed links to chronic diseases such as obesity, autoimmune diseases, heart, lung and liver diseases, and cancer in adulthood.1 Since then, further evidence has revealed relationships between ACEs and physical and mental health outcomes, such as increased risk of substance abuse, suicide and premature mortality.4 7

Approximately 37 % of all children live in poverty for some period during their childhood.16 Children who are born into poverty and live persistently in poor conditions are at greatest risk of adverse outcomes.

Recent examinations into the outcomes of childhood trauma have resulted in findings that demonstrate the notion that extreme childhood adversity is not only linked to undesirable juvenile and adult behaviors, but that there is also an intergenerational risk factor associated with adverse experiences at a young age (e.g., Bifulco et al., 2002; Chartier, Walker, & Naimark, 2010; Felitti et al., 1998; Gregorowski & Seedat, 2013; Mersky, Topitzes, & Reynolds, 2013; Sameroff, 2000).

Maternal glucose at 28 weeks of gestation is not associated with obesity in 2 - year - old offspring: the Belfast Hyperglycemia and Adverse Pregnancy Outcome (HAPO) family study

Where both parents are depressed, the child is at far greater disadvantage and poorer outcomes have been observed in children up to the age of 7.32 Heightened parental anxiety may result in adverse outcomes for the child, who is also put at increased risk of anxiety.33 Given that children born preterm are already at some disadvantage in comparison to their peers born at term, an increase in the prevalence of PD among this group of parents could compound the negative impact of an early delivery on child outcomes.