Sentences with phrase «of aged mice»

There is increased ER stress in the pancreas of aged mice.

At 10 months of age the mouse models were found have no amyloid plaque deposits at all.

One group of aged mice was fed resistant starch while the control group was fed highly digestible starch.

Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors.

View our related Science in the Classroom annotated research paper on rejuvenation of the aging mouse brain.

In another experiment, the researchers used viral gene transfer and increased RbAp48expression inthe DG of aged mice.

Furthermore, examination of aged mice showed dramatically reduced levels of Cbf - beta in bone marrow cells, as compared to younger mice.

Since then, Stanford researchers and others, including Wagers, have published about a half - dozen papers showing that old - young parabiosis can also improve the health of an aging mouse's liver, spinal cord, and brain.

At Cornell, he studied the metabolism of neurotransmitters, including dopamine, in the noggins of aging mice.

It also partially restored protein solubility in the lenses of aged mice in vivo and in human lenses ex vivo.

The researchers also did functional MRI (fMRI) studies of the mice with inhibited RbAp48 and found a selective effect in the DG, similar to that seen in fMRI studies of aged mice, monkeys, and humans.

Rapamycin significantly reduced the proportion of aged mice presenting with cancers and / or precancerous lesions upon pathological assessment in the 16 - month cohort (vehicle, 4 of 10; rapamycin, 0 of 15; P = 0.0166, Fisher exact test), but had no measurable effect in the 25 - month cohort (vehicle, 1 of 5; rapamycin, 2 of 8; P = 1.0, Fisher exact test) or the 34 - month cohort (vehicle, 1 of 5; rapamycin, 3 of 10; P = 1.0, Fisher exact test).

In particular, the microbiota of aged mice fed resistant starch had higher levels of Bacteroidetes and Bifidobacterium, Akkermansia, and Allobaculum species in proportions that were dependent on the concentration of the resistant starch.

Accordingly, by performing genetic or pharmacological interventions to limit TOR activity chronically, the researchers were able to prevent or reverse stem cell loss in tracheae and muscle of aging mice.

In another experiment, the researchers used viral gene transfer and increased RbAp48 expression in the DG of aged mice.

According to a study published in Science, the protein, called growth differentiation factor 11 (GDF11), can reverse the decline in blood vessel volume seen in the brains of aging mice and enhance neurogenesis (the generation of new nerve cells).