Sentences with phrase «of aggregated proteins»

The biggest surprise came when the team looked at the fates of aggregated proteins.

Optineurin is involved, for example, in the elimination of aggregated proteins and bacterial infection defense.

A common feature of neurodegenerative diseases such as Alzheimer's, Parkinson's or Huntington's disease are deposits of aggregated proteins in the patient's cells that cause damage to cellular functions.

They traced the effect to increased production of a specific type of lipid that, surprisingly, prevented the formation of aggregate proteins.

Patrik Verstreken (VIB / KU Leuven): «We have set up a new in vitro system specifically for this research, to enable us to study the distribution throughout the brain of aggregate proteins that are typical of neurodegenerative diseases.

5 µl of aggregated protein slurry was then placed on the top of a diamond PRO450 - S attenuated total reflectance unit from Jasco Products, adapted to the FT / IR -4100 system.

Not exact matches

Co-lead researcher, Australian National University Professor John Carver, said that two unrelated proteins aggregate in UHT milk over a period of months to form clusters called amyloid fibrils, which cause the milk to transform from a liquid into a gel.

As an amphiphilic emulsifier and stabilizer, acacia gum is a complex aggregate of molecular fractions, including: arabinogalactan protein (AGP); arabinogalactan peptide (AG); and glycoprotein (GP).

«Large aggregates of ALS - causing protein might actually help brain cells: UNC School of Medicine scientists add to evidence that small aggregates of SOD1 protein are the brain - cell killing culprits in ALS, but the formation of larger, more visible, and fibril - like aggregates of the same protein may protect brain cells.»

Left: cells with large, fibril - like aggregates of SOD1 protein.

Many of the candidate drugs developed in recent years were designed to clear these protein aggregates.

If the necessary ribosome - associated quality control machinery (RQC) does not function properly, defective proteins accumulate and form toxic aggregates in the cytoplasm of the cells.

In order to get rid of these toxic aggregates, cells have developed an elaborate protein quality control system, which the researchers now describe in the journal Cell.

Once CAT - tailed proteins are imported into the mitochondria, they form aggregates that may act as a seed, and ultimately bind proteins free of defects that have vital roles for the cell» explains Toshiaki Izawa, first author of the study, together with Sae - Hun Park.

Hartl has been investigating protein aggregates, a cellular cause of neurodegenerative diseases, for many years.

Remarkably, mice raised in the germ - free cages displayed fewer motor deficits and reducedaccumulation of misfolded protein aggregates in brain regions involved in controlling movement.

While these compounds did not reduce the amount of protein aggregates, they were found to reduce the protein's toxicity and to increase the stability of amyloid fibrils — a finding that lends further evidence to the theory that smaller assemblies of amyloid - beta known as oligomers, and not the fibrils themselves, are the toxic agents responsible for Alzheimer's symptoms.

However, scientists have long debated whether the proteins themselves or primarily their aggregates cause the neurological decline characteristic of Huntington's.

Taken together, the results suggest that gut microbes exacerbate motor symptoms by creating an environment that could favor the accumulation of misfolded protein aggregates.

Lessons learned in this disease could help foster understanding of how these types of diseases develop, and what role the protein aggregates play.

A protein fragment called amyloid - beta (Aβ) is known to aggregate and create plaque in the brains of Alzheimer's patients.

Feeding the fruit flies spermidin significantly reduced the amount of protein aggregates in their brains, and their memories improved to juvenile levels.

The ever - growing crowd of misfolded proteins form the aggregates seen in the brains of patients with neurodegenerative disorders such as Parkinson's and Alzheimer's diseases.

Key to this process is a repetitive stretch of a protein building block called glutamine, which is known to serve as a glue for protein aggregates in disease.

The background image shows a picture of the nematode C. elegans with clumps of the Huntington's aggregates (bright green because they're tagged with green fluorescent protein) in the body wall muscle cells.

Also, as therapies are developed to treat protein - aggregation - based pathologies, it will be critical to consider that there may be many useful aggregates that should not be destroyed in the process of treating disease - causing aggregates.

«We already know from previous studies on the protein huntingtin, which spontaneously forms aggregates and is responsible for the development of the neurodegenerative disorder Huntington's disease, that protein aggregates also bind to essential proteins that have no defects.»

As more examples of useful protein aggregation are identified, it should become clear how aggregates are regulated so that they do not reach toxic levels associated with diseases.

«Stop signals against protein clumps: Synthesis of faulty protein chains leads to the formation of toxic aggregates.»

In several diseases of the brain, long fibres of protein form, and eventually become tangled to form dense bodies known as «plaque» or «aggregates.»

«Crick slightly anticipates, in one sentence, that perhaps what we have is a form of protein that aggregates somewhere,» he said.

«We were able to show that the formation of aggregates is promoted by defects in the protein blueprint and these are not detected by the internal quality control machinery,» explains Young - Jun Choe, first author of the study together with Sae - Hun Park.

A determining cause is believed to be protein deposits — aggregates of misfolded proteins.

This research on these protein clusters, or aggregates as scientists call them, could help guide design of new anticancer drugs.

«Our results not only demonstrate a potential mechanism for the development of neurodegenera - tive disorders but we have also found another example of the way in which proteins can form aggregates and damage the cell.

«If Ltn1p is not active in pathologically modified cells or if other components of quality control are missing, defective proteins accumulate and form aggregates in cell interiors,» says Park.

They confirmed the number of repeats is critical to how many proteins are needed to start an aggregate.

Previously, researchers have shown that treating cells with neuregulin - 1, for example, dampens levels of amyloid precursor protein, a molecule that generates amyloid beta, which aggregate and form plaques in the brains of Alzheimer's patients.

The mutant Huntingtin gene is thought to cause toxic levels of protein to aggregate in the brain.

But mutations, which are found in 96 percent of patients with high - grade serous ovarian tumors, can cause p53 to form clumps, or «aggregates,» which impair the protein's normal function.

A typical characteristic of the brain of an Alzheimer sufferer is the presence of insoluble Tau protein aggregates.

«These findings suggest that the ability of proteins to aggregate into amyloid fibrils can be considered a more general property of proteins than previously believed,» says Massimo Stefani, a protein chemist at the University of Florence in Italy who co-led the project.

The findings shed new light on the biological nature of protein aggregates, which have been widely considered to be toxic dead - end products, but are increasingly being recognized as a new layer of cellular organization.

In addition to determining that protein aggregation is regulated and requires active translation, Stowers scientists revealed that the mitochondria, the cell's powerhouses, play a key role in the mobility of these protein aggregates.

Scientists at the Stowers Institute for Medical Research have made a surprising finding about the aggregates of misfolded cellular proteins that have been linked to aging - related disorders such as Parkinson's disease.

In the brains of patients with Alzheimer's disease (AD), amyloid precursor protein is broken apart, and the resulting fragments — β - amyloid peptides, or Aβ peptides — aggregate to form plaques.

Protein aggregates that form after a cell is exposed to high, non-lethal temperatures appear to be part of an organized response to stress, and not the accumulation of damaged proteins en route to destruction.

«In contrast to what's been observed in many studies on foreign proteins and mutant cells, disassembly of native aggregates after heat shock in normal cells is essentially complete under these conditions,» Drummond said.

«Aggregation likely inactivates the vast majority of proteins, but it's remarkable that some can remain active when aggregated.

The researchers identified more than 175 different proteins that aggregated in response to heat shock, representing around a sixth of the proteins measured and about ten times as many as were known before.