Researchers in Uppsala together with colleagues from Lund as well as Namibia, Botswana, France, and the USA have studied the microscopic structure
of aggregates formed with the protein.
Not exact matches
Enthusiasm for auto debt comes at a time when
aggregate growth
of mortgages, credit cards, lines
of credit and other
forms of borrowing has slowed.
«The possibility that stock value in
aggregate can become irrationally high is contrary to the hard -
form «efficient market» theory that many
of you once learned as gospel from your mistaken professors
of yore.
In the course
of recent months, the JPY has commanded Bitcoin exchange volumes against different monetary
forms with 40 - 60 %
of the
aggregated volume.
Modernised reporting
forms that are collected by APRA on behalf
of the RBA and the Australian Bureau
of Statistics will significantly improve the
aggregate and institution - level data that are currently collected from ADIs and registered financial corporations (RFCs).
may be reflected in the
form of prospectus filed with the Securities and Exchange Commission pursuant to Rule 424 (b) if, in the
aggregate, the changes in volume and price represent no more than a 20 percent change in the maximum
aggregate offering price set forth in the «Calculation
of Registration Fee» table in the effective registration statement; and
It seems to be, in other words, an
aggregate of actual occasions possessing a «common element
of form.»
Robert Kane & Stephen Phillips (Albany, NY: SUNY Press, Forthcoming), 16: «Leibniz's most important but largely ignored contribution, Hartshorne says, was his distinction between two types
of things that can be
formed when multitudes
of low - grade individua1s are joined together: compound individuals and mere
aggregates.
The philosophy
of absolute idealism, so vigorously represented both in Scotland and America to - day, has to struggle with this difficulty quite as much as scholastic theism struggled in its time; and although it would be premature to say that there is no speculative issue whatever from the puzzle, it is perfectly fair to say that there is no clear or easy - issue, and that the only obvious escape from paradox here is to cut loose from the monistic assumption altogether, and to allow the world to have existed from its origin in pluralistic
form, as an
aggregate or collection
of higher and lower things and principles, rather than an absolutely unitary fact.
When AAFRC announces charitable giving according to its «use» categories, it does so in
aggregate form, without acknowledging changes in population or the amount
of taxes paid.
First, there is the inorganic
form of individuality in which the composite whole is merely the sum
of its parts, i.e., the entity in question is a simple «
aggregate,» a non-individual, so to speak.
-LSB-...] These common values do not constitute an anarchic or uncertain
aggregate but
form a coherent whole which is ordered and expressed historically on the basis
of a precise anthropological vision.
Below the threshold
of sense perception
of corpuscular
aggregates there is a dimmer and cloudier impression
of things as not yet sharply set out in distinct shapes and
forms.
These monads group themselves together to
form the objects
of our everyday experience, none
of which are single substances, and all
of which are
aggregates of substances (i.e.,
of monads) 11 (M 70).
A more likely view, and one held by many competent interpreters, is that this present collection
of ten commandments, this Decalogue, this
aggregate of «ten words,» probably represents not an original nucleus around which the growing fullness
of Old Testament torah
formed, not a chronologically prior basic code which was subsequently expanded, but rather a self - conscious, consummately discerning effort to reduce to its most significant essence a relatively comprehensive and detailed body
of torah.
Then they
aggregate at a number
of centers to
form at each center a slug - like creature that slithers like a slug.
Co-lead researcher, Australian National University Professor John Carver, said that two unrelated proteins
aggregate in UHT milk over a period
of months to
form clusters called amyloid fibrils, which cause the milk to transform from a liquid into a gel.
Ronaldino was in sparkling
form that night at Stamford Bridge, but it wasn't enough as goals from Eidur Gudjohnsen, Frank Lampard, Damien Duff and John Terry saw the Blues through 5 - 4 on
aggregate, and they would later be cruelly knocked out
of the semi-final by a Luis Garcia's «ghost goal» for Liverpool in the semi-final second leg at Anfield.
And, based on current
form, that looks set to worsen over the course
of the weekend, as Kean has been unable to prevent the team from losing four successive games away from home, to an
aggregate score
of 13 - 4, Rovers shipping exactly 4 goals in their previous two away clashes alone.
The club's downturn in
form was so severe — during 70 days from January 31 onward, they won just two
of eight in the league and were bounced out
of the Champions League 10 - 2 on
aggregate by Bayern Munich — that at any comparable club, Wenger's tenure would likely have been terminated.
The 2017 - 18 Champions League round
of 16 witnessed an upset in the
form of Manchester United being knocked out by Sevilla, by 2 - 1 on
aggregate.
Parenting Ideas collects non-personal information in
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of visits to our Service, the number
of visits to specific areas
of our Service, the sources
of referral to our Service, and devices used to access our Service.
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form, medium, or technology now known or later developed.
In count five and six, FG alleged that Yakubu had with intent to avoid a lawful transaction under the law, transferred at various times in Kaduna,
aggregate sums
of $ 9,772, 800 and # 74, 000, when he reasonably ought to know that the said funds
formed part
of the proceed
of some
form of unlawful activity and thereby committed an offence contrary to section 7 (4)(b)(ii)
of the Advance Fee Fraud Act, 2006.
One
of the counts reads: «That you Air Chief Marshal Alex S Badeh (whilst being the Chief
of Air Staff, Nigerian Air Force) and IYALIKAM NIGERIA LIMITED between 28th March and 5th December, 2013 in Abuja within the jurisdiction
of this Court, did use an
aggregate sum
of N878, 362,732.94 (Eight Hundred and Seventy - Eight Million, Three Hundred and Sixty Two Thousand, Seven Hundred and Thirty - Two Naira, Ninety - Four kobo) removed from the accounts
of the Nigerian Air Force and paid into the account
of Rytebuilders Technologies Limited with Zenith Bank Plc for the construction
of a shopping mall situate at Plot 1386, Oda Crescent Cadastral Zone A07, Wuse II, Abuja for yourself, when you reasonably ought to have known that the said funds
formed part
of the proceed
of unlawful activity (to wit: criminal breach
of trust and corruption)
of Air Chief Marshal Alex S Badeh and you thereby committed an offence contrary to Section 15 (2)(d)
of the Money Laundering (Prohibition) Act, 2011 (as amended) and punishable under Section 15 (3)
of the same Act»
If the necessary ribosome - associated quality control machinery (RQC) does not function properly, defective proteins accumulate and
form toxic
aggregates in the cytoplasm
of the cells.
The stone's noble gas content supports an extraterrestrial origin, while the presence
of tiny diamonds — larger than nanodiamonds found in a common kind
of meteorite called chondrites, but similar in size to diamond
aggregates known to be
formed by impacts — supports a cometary origin.
By
aggregating the sizes
of the modern dark asteroids, researchers suggest the original dark planetesimals
formed about 4 billion years ago, making this one
of the oldest asteroid families in the main belt; most asteroid families are thought to have
formed about 1 billion years ago.
Once CAT - tailed proteins are imported into the mitochondria, they
form aggregates that may act as a seed, and ultimately bind proteins free
of defects that have vital roles for the cell» explains Toshiaki Izawa, first author
of the study, together with Sae - Hun Park.
The other piece was insoluble, so the researchers had to use a solution
of micelles — dispersed lipid or detergent - like
aggregates in a solution — to let the insoluble piece
form its structure within a membrane - like environment.
But this
form of tissue regeneration does not occur in humans, so the researchers recreated similar conditions in the laboratory by growing human cells as 3D
aggregates.
It remains unknown whether the clusters
form critical nuclei that grow classically by single - ion attachment or
aggregate and then precipitate and how the precipitation
of different ACC phases at different pH values can be explained precisely, because several options exist (Fig. 4).
The ever - growing crowd
of misfolded proteins
form the
aggregates seen in the brains
of patients with neurodegenerative disorders such as Parkinson's and Alzheimer's diseases.
The changing color is a visualization
of changing experimental conditions that give rise to the different bulk properties
of a liquid, as
aggregates are
formed in different degrees.
«We already know from previous studies on the protein huntingtin, which spontaneously
forms aggregates and is responsible for the development
of the neurodegenerative disorder Huntington's disease, that protein
aggregates also bind to essential proteins that have no defects.»
In several diseases
of the brain, long fibres
of protein
form, and eventually become tangled to
form dense bodies known as «plaque» or «
aggregates.»
«Crick slightly anticipates, in one sentence, that perhaps what we have is a
form of protein that
aggregates somewhere,» he said.
«But every possible effort, every feasible level
form of contribution from whatever source — small, medium, big countries — we would need all
of them because what really matters is to
aggregate all these efforts.»
The researchers considered two possible explanations: Disease suppression might be the result
of one or two additional substitutions on the same gene that buffer the harmful effect
of the mutation; or suppression may be caused by numerous small substitutions throughout the genome that
form an
aggregate «shield.»
«Our results not only demonstrate a potential mechanism for the development
of neurodegenera - tive disorders but we have also found another example
of the way in which proteins can
form aggregates and damage the cell.
«If Ltn1p is not active in pathologically modified cells or if other components
of quality control are missing, defective proteins accumulate and
form aggregates in cell interiors,» says Park.
This time, Wolynes and his team were interested in knowing how the varying length
of repeats — as few as 20 and as many as 50 — influenced how
aggregates form.
While typically thought
of as solitary life
forms, microbes frequently
aggregate to
form dense cell clusters.
Previously, researchers have shown that treating cells with neuregulin - 1, for example, dampens levels
of amyloid precursor protein, a molecule that generates amyloid beta, which
aggregate and
form plaques in the brains
of Alzheimer's patients.
But mutations, which are found in 96 percent
of patients with high - grade serous ovarian tumors, can cause p53 to
form clumps, or «
aggregates,» which impair the protein's normal function.
The algae and its marine snow
aggregates can serve as a major food source for other
forms of marine life like plankton - eating fish and shellfish.
In the brains
of patients with Alzheimer's, amyloid peptides
aggregate to
form oligomers and plaques that are thought to be responsible for the disease symptoms.
Apart from that, the research has a practical use: long - term cultures
of multicellular
aggregates,
forming during the reaggregation process, may become a basis for producing biologically active substances used in pharmaceutics and cosmetics.
In the brains
of patients with Alzheimer's disease (AD), amyloid precursor protein is broken apart, and the resulting fragments — β - amyloid peptides, or Aβ peptides —
aggregate to
form plaques.
Protein
aggregates that
form after a cell is exposed to high, non-lethal temperatures appear to be part
of an organized response to stress, and not the accumulation
of damaged proteins en route to destruction.