Sentences with phrase «of aging tissues»

MDI Biological Laboratory Associate Professor James A. Coffman, Ph.D., is studying the regenerative capacity of sea urchins in hopes that a deeper understanding of the process of regeneration, which governs the regeneration of aging tissues as well as lost or damaged body parts, will lead to a deeper understanding of the aging process in humans, with whom sea urchins share a close genetic relationship.

This approach is rooted in the century - old concept of heterochronic parabiosis, whereby exposure of aged tissues to young factors can extend organismal lifespan and improve aged tissue function.

For setting cancer in the context of ageing tissue, study of normal adult homeostasis is important — we are studying mutational processes, clonal dynamics and cellular competition in thousands of non-cancerous cells and samples from a range of tissue types, in health and disease.

Possible reasons for this include the fact that most stem cell treatments, even without addressing issues of the aged tissue environment, represent a considerable improvement in the scope of what is possible to achieve through modern medicine.

Not exact matches

-- Ashley Black, bestselling author of The Cellulite Myth, coauthor of the scientific paper «The Effects of a Fascia Manipulation Device on Subcutaneous Fat Tissue and Cellulite Appearance in Middle Aged Women,» and inventor of the FasciaBlaster

Last year a woman who had an ovary frozen at the age of 13 gave birth after doctors used the tissue to restore her fertility.

The technology may correct loss of organ and tissue function with age, diseases or trauma.

conditions such as premature aging of the skin and inflammation of various tissues.

These particular amino acids are found to generate cell growth much quicker because the natural ability to produce supporting amounts of connective tissue diminishes after the age of 25.

If you want to improve the look and feel of your skin, collagen is known to enhance the softness and support of the skin tissue and reduce wrinkles and aging.

Malfunctioning mitochondria can cause problems in every cell in the body, contributing massive stress to our internal environment, increasing inflammation, rapid breakdown of tissues, and eventually degeneration of the human body (AKA rapid aging).

In the middle of his lean black torso a knot of scar tissue the color and breadth of a Ping - Pong ball emblazoned a grotesque reminder of his despair, a badge of the degeneration that made him an unlikely and, ultimately, unsuccessful pro rookie at the age of 25.

A study in 2011 looking at more than 645 ACL surgeries found that in patients between the ages of 10 ««19, allograft tissue had a four times higher failure rate than using your own tissue.

Recent studies show nearly half of all children aged 2 and 3 have at least mild inflammation of gum tissues.

Though it is rare in preschool children and usually occurs in adolescence and adulthood, up to 35 % of children between the ages of 3 to 5 have some form of gingivitis, a periodontal disease that is caused by inflammation or infection of periodontal tissue.

As we age, our skin loses some of its elastic properties and if it stretched significantly — like say, over two growing babies — the connective tissue often tears rather than stretches.

For the study, the data of 31 men (mean age of 67.2 years) who had undergone prostatectomies and preoperative PET scans were analyzed, with the SUVmax generated for suspicious areas and visually normal tissue.

In this study, researchers analyzed ovarian tissue from populations of reproductively «young» (equivalent to women in their early twenties) and «old» mice (equivalent to women ages 38 - 45).

«The level of preservation in combination with the age is remarkable,» says Frank Rühli at the University of Zurich, Switzerland, who has examined medieval brain tissue.

Lead author David W. Frederick, PhD, a postdoctoral fellow in the Baur lab, and the team generated mice in which they could restrict the amount of NAD in specific tissues in order to simulate this aspect of normal aging in otherwise healthy mice.

The scientists compared that tissue with brain tissue samples from three young amateur American football players and a professional wrestler, all of whom had a history of repetitive concussive injury, and with four samples from comparably aged control subjects with no history of blast exposure, concussive injury or neurological disease.

A technique to keep the tips of your chromosomes healthy could reverse tissue ageing.

The risk of diabetes was highest for women, who have more fatty tissue to sequester PCBs, compared to men in the same age groups.

Recent studies suggest that the total loss in brain volume due to atrophy — a wasting away of tissue caused by cell degeneration — between our teen years and old age is 15 percent or more, which means that by the time we're in our seventies, our brains have shrunk to the size they were when we were between 2 and 3 years old.

The immediate payoff was a commercialization deal in age - related macular degeneration in which Pfizer became the first big pharma company to make a move into the use of embryonic stem cells as the basis for a tissue regeneration therapy.

IBM developed a technique for making carbon nanotubes emit light, paving the way for new fiber optics; Harvard scientists figured out how to deposit tiny wires on glass or plastic, opening the door for the development of supercheap computers; and at the University of Central Florida, neuroscientist Beverly Rzigalinski discovered a nanomolecular fountain of youth effect: When Rzigalinski applied cerium oxide nanoparticles to rat neurons in a petri dish, the particles seemed to strip out the free radicals that make tissues age and kept the neurons alive and functioning up to six times their normal life span.

The device can treat either form of age - related macular degeneration: the dry stage, where the delicate tissues of the macula become thinned and slowly lose function, or the less common wet stage that's caused by the growth of abnormal blood vessels behind the macula.

Scientists at the Barshop Institute for Longevity and Aging Studies, part of the School of Medicine at the UT Health Science Center at San Antonio, have found another secret of longevity in the tissues of the longest - lived rodent, the naked mole rat.

Functions in all three of those tissues are known to decline with age.

Yin is using zebrafish to study the regeneration of heart tissue because of the amazing capacity of these common aquarium fish to regenerate the form and function of almost any body part, including heart, bone, skin and blood vessels, regardless of their age.

Yin and other scientists conducting research in the institution's Kathryn W. Davis Center for Regenerative Medicine study tissue repair, regeneration and aging in a diverse range of organisms that have robust mechanisms to repair and regenerate tissue.

«There have been factors found that are suggested to be aging factors,» Lee says, «but there has not been identification of a circulating factor that can go the other way, of turning the old tissue into younger tissue.»

The Center's goal is to understand basic mechanisms of tissue and organ formation, and then to use this knowledge to regenerate, repair, and replace tissues damaged by aging, disease and injury.

Tissues outside of the bones don't naturally calcify, yet mineralization of organs, including the heart, blood vessels, and kidneys, occurs with age and is exacerbated in people with diabetes or kidney disease.

The UCLA team identified 353 DNA markers from 51 types of cells and tissues and examined how age affects their DNA methylation levels throughout a lifetime.

And the trouble with extrapolating so much from mouse studies is that «nobody has actually shown over the long term how long these quote un-quote improvements persist, and we don't know whether it's broadly improving aspects of aging or it's specific to certain tissues,» said Matt Kaeberlein, a biologist who studies aging in dogs and other animal models at the University of Washington.

Regenerative medicine represents a new frontier in science, which seeks to understand the mechanistic basis of tissue aging, repair, and regeneration and to leverage this knowledge to improve human health.

«The 353 markers on the DNA provide a weighted average that gives you a very accurate measure of the age of the tissue,» says Horvath.

About half of all screening - aged women have dense breast tissue, according to Deborah Rhodes, M.D., a Mayo Clinic Breast Clinic physician and the senior author of this study.

So much of the loss of function and vitality that commonly accompanies aging actually begins with this gradual loss of muscle tissue starting in mid-life.

While changes in insulin secretion are unlikely to play a major role in the acute effects of SD, cellular stress in pancreatic tissue suggests that chronic SD may contribute to the loss or dysfunction of endocrine cells, and that these effects may be exacerbated by normal aging, say the researchers.

Naidoo is also senior author of a follow - up study in Aging Cell this month that shows, for the first time, an effect of sleep deprivation on the UPR in peripheral tissue, in this case, the pancreas.

«This hallmark of many old tissues,» explains Judith Campisi of the Buck Institute for Research on Aging in Novato, Calif., «will generally promote the growth of cancer.»

The investigators suggest that the premature loss of estrogen caused by the oophorectomy may affect a series of aging mechanisms at the cellular and tissue level across the whole body leading to diseases in multiple systems and organs.

Senescence is associated with normal aging, and senescent cells accumulate in aged tissues, which impair the normal functions of the tissue and contribute to age - related diseases.

Now Yamanaka and his colleagues report in the journal Cell that the same combination of genes induced pluripotency in commercially available human fibroblasts (connective tissue cells that play a crucial role in healing) derived from the facial skin of a 36 - year - old woman, the joint tissue of a man, aged 69, and a newborn, respectively.

There is a lot of work still to do, and many potential pitfalls before it could be applied to human patients, but in principle almost any illness caused by damaged or ageing tissue — heart disease, diabetes, Alzheimer's and dozens of others — could be fixed this way.

Stem cells, which have to divide regularly to regenerate tissues with new cells, can produce telomerase, but not the amount required to counteract the shortening of telomeres that accumulates with aging: over time, the tissues have fewer fresh cells and they lose their regenerative capacity.

As a result, they have less than half of the fat tissue found in normal, aged mice.

The mice with age - related disease, they found, had abnormally high levels of immune cells called T regulatory cells (Tregs) inside their fat tissue.