Women generally have lower levels
of alcohol dehydrogenase, an enzyme in the liver that metabolizes alcohol, and therefore are advised to drink smaller amounts.
Emerging research suggests that curcumin, the active compound in turmeric, may effectively support the activity
of alcohol dehydrogenase in a way that protects against liver damage.
Previous work on gender differences in alcohol dependence has shown that women get drunk on fewer drinks than men owing to a deficit
of alcohol dehydrogenase, the enzyme in the stomach lining that breaks down booze.
Not exact matches
The mutation in
alcohol dehydrogenase would have protected those who had it from some
of the nefarious effects
of alcohol and alcoholism.
Bierut: So there are multiple different pathways to alcoholism and some
of them are pharmacologic - type pathways
of how a person metabolizes
alcohol — how they respond to it with the
alcohol dehydrogenase or acetaldehyde
dehydrogenase, two important enzymes that are involved in the metabolism
of alcohol, and we would kind
of think [
of] that as a more direct
alcohol - related route to the development
of alcoholism.
Steve: This is really interesting material, I think, because perhaps many
of the listeners are familiar with older research, for example, that found that the aldehyde
dehydrogenase enzyme is not available for certain people, and that for them, drinking in excess is really uncomfortable, so they tend not to, but that's more
of a direct genetic biochemical kind
of a system related to the
alcohol molecule ultimately as it gets metabolized.
A study
of the interplay between peer drinking and the functional polymorphism rs1229984 in the
alcohol dehydrogenase 1B gene (ADH1B) in the development
of adolescent drinking milestones has found that peer drinking reduces the protective effects
of an ADH1B variant.
10 Chemistry
of a cheap date: Women produce only 60 percent as much
alcohol dehydrogenase, the enzyme that neutralizes booze, as men do.
Among East Asians, the researchers found a strong signal
of selection in the
alcohol dehydrogenase (ADH) cluster, the enzymes that break down
alcohol.
One
of the enzymes that facilitates this process is
alcohol dehydrogenase, which is coded for by the ADH gene.
Other groups suggested that the sequestration
of heme or the interaction between Aß and the Aß - binding
alcohol dehydrogenase might explain the observed complex IV deficits [64].
Adding insult to injury: In women, the enzyme aldehyde
dehydrogenase (ALDH)-- which breaks down
alcohol in the stomach — can work less efficiently than in men, says Scott Walters, PhD, associate professor at the University
of Texas School
of Public Health.
activates
alcohol dehydrogenase, the enzyme needed for transformation
of hydroxylated toxins from their
alcohol form to an intermediate (often more toxic) aldehyde form