Sentences with phrase «of aldose»

Investigation of the Functional Role of Aldose 1 - Epimerase in Engineered Cellobiose Utilization, Sijin Li, Suk - Jin Ha, Hee Jin Kim, Jonathan M. Galazka, Jamie H.D. Cate, Yong - Su Jin, Huimin Zhao, Journal of Biotechnology, 168 (1): 1 - 6.

«Working closely with Professor Srivastava and other UTMB faculty, the next step is to prove the safety and efficacy of aldose reductase inhibitors for these conditions and develop them to improve the health of millions of people,» said Jason Abair, associate vice president of the center.

Not exact matches

«The discovery that aldose reductase regulates mucus production and goblet cell metaplasia makes inhibition of this enzyme an attractive therapeutic option to reduce mucus - related airway obstructive diseases — and for the first time gives us a real chance to alter the course of the underlying disease in asthma and COPD.»

Researchers have proved that a single «master switch» enzyme, known as aldose reductase, is key in producing excess mucous that clogs the airways of people with asthma and chronic obstructive pulmonary disease (COPD).

The next step, Srivastava said, is clinical trials of the drugs as a therapy for asthma and COPD — a process that should be expedited since aldose reductase inhibitors have already undergone Phase III clinical trials for diabetic neuropathy.

«Aldose reductase is key to a whole range of inflammation disorders, so it comes as no surprise that it should be crucial to the inflammatory processes that drive disease in asthma and COPD,» said UTMB Health biochemistry and molecular biology professor Satish Srivastava, senior author of the paper.

High - fat diet induced neuropathy of pre-diabetes and obesity: effects of «healthy» diet and aldose reductase inhibition.

Aldose reductase is the first enzyme in the sorbitol - aldose reductase (polyol) pathway [12] responsible for the reduction of glucose to sorbitol, as well as the reduction of galactose to galacAldose reductase is the first enzyme in the sorbitol - aldose reductase (polyol) pathway [12] responsible for the reduction of glucose to sorbitol, as well as the reduction of galactose to galacaldose reductase (polyol) pathway [12] responsible for the reduction of glucose to sorbitol, as well as the reduction of galactose to galactitol.

Also, from Wikipedia re Sorbitol, the Polyol Pathway and Aldose Reductase: «While most cells require the action of insulin for glucose to gain entry into the cell, the cells of the retina, kidney, and nervous tissues are insulin - INdependent, so glucose moves freely across the cell membrane, regardless of the action of insulin.

[13] Mechanisms that may account for lipoic acid's benefit in preventing diabetic complications include prevention of protein glycosylation [14] and inhibition of the enzyme aldose reductase, the latter of which subsequently inhibits conversion of glucose and galactose to sorbitol.