Four dogs with this allele were DNA sequenced, and none contained the SNP
of allelic variant 1.
Most
of the allelic variants represent disease - causing mutations.
Not exact matches
Mutations are cataloged in OMIM in the
Allelic Variants section
of gene entries (see 1.2).
By looking at your specific
allelic variants of your HLA family
of genes, genetic testing can help you determine if genetics play a role in your gluten sensitivity.
Allelic variant 3 is an insertion
of 24 nucleotides at position -78
of the canine Cox - 2 gene (CGCCTCCGCCTCCGCCTCCGCCGC).
The
allelic variant, RS3 334, is associated in men, but not women, with a lower bonding quality with the partner (characterized by lower scores on the partner bonding scale and a greater likelihood
of reporting martial problems)(Walum et al., 2008).