Bromelain Exerts Anti-Inflammatory Effects in an Ovalbumin - Induced Murine Model
of Allergic Airway Disease.
Enhanced Expression of Myristoylated Alanine — Rich C Kinase Substrate (MARCKS) in Airway Epithelium of an Animal Model
of Allergic Airway Inflammation and Human Patients with COPD
Dr. Julie Deckers (VIB - UGent): «As predicted, our test showed that house dust mite - induced skin inflammation leads to aggravated levels
of allergic airway inflammation.
UFZ researchers and their colleagues from the University of Leipzig have recently been successful in finding a protein that plays a critical role in the development
of allergic airway inflammation.
Tobias Polte and his team from the Department of Environmental Immunology at the Helmholtz Centre for Environmental Research (UFZ) collaborated with Jan Simon and his colleagues from the Clinic for Dermatology, Venereology and Allergology at the University of Leipzig and have recently been successful in discovering a molecule that plays a significant role in the development
of allergic airway inflammation — as demonstrated in their recent publication in Nature Communications.
Not exact matches
In some rare cases, severe
allergic reaction symptoms can cause swelling
of the tongue and
airway blockage.
Specifically, the researchers found that a peptide, called STAT6 - IP, when delivered to the lungs
of neonatal mice at the time
of first RSV exposure reduces the development
of allergic - type lung inflammation and
airway hyperresponsiveness («twitchy»
airways) in mice when they are «re-challenged» with RSV as young adults.
«Asthma and
airway allergic responses are among the most common chronic diseases in childhood affecting more than 6 million children in the US,» said John Wherry, Ph.D., Deputy Editor
of the Journal
of Leukocyte Biology.
The experiments indicated that when dectin - 1 recognizes tropomyosin in house dust mites, shrimp or other common allergy - triggering species it suppresses
airway cells» production
of an immune molecule, IL - 33, which otherwise would promote an
allergic response by immune cells.
Lead researchers Associate Professor Chrishan Samuel and Dr Simon Royce tested the efficacy
of the MSCs on three key components
of asthma in a preclinical model
of chronic
allergic airways disease: inflammation;
airway remodeling (structural changes that occur in lungs as a result
of prolonged inflammation); and
airway hyperresponsiveness (the clinical symptom
of asthma).
Read the full paper titled Intranasal administration
of mesenchymoangioblast - derived mesenchymal stem cells abrogates
airway fibrosis and
airway hyperresponsiveness associated with chronic
allergic airways disease published in the FASEB Journal.
Previous studies have demonstrated that there are various levels
of inflammatory responses in patients who suffer from asthma, and
allergic airway inflammation with increasing EOS is the main pathological feature
of asthma (20,21).
Asano T, Kume H, Taki F, et al: Thalidomide attenuates
airway hyperresponsiveness and eosinophilic inflammation in a murine model
of allergic asthma.
Career Goals: Developing
of novel immunotherapeutic strategies for the treatment
of chronic
allergic inflammation and
airway remodeling.
RIPK2 gene silencing in the
airways decreased
allergic airway inflammation in an ovalbumin - mediated mouse model
of asthma (Jun et al., 2013).
He did his Ph.D from University
of Pune in Biotechnology in identifying posttranscriptional regulation
of cytokine IL - 10 and its effect on
allergic airway inflammation.
An inflammation
of the nasal
airways,
allergic rhinitis is linked with a sensitized immune system that overreacts to what should be a benign stimulant.
The combination
of vitamins E and C to enhance
airway antioxidant levels in people with
allergic asthma and reduce the incidence
of preeclampsia among pregnant women with chronic hypertension or a history
of preeclampsia / eclampsia
Symptoms
of allergic reactions can range from itching to obstruction
of the
airways — which may lead to death if not treated immediately.
In one study, researchers at the University
of Connecticut found that bromelain reduced
airway inflammation in animals with
allergic airway disease.
One possible explanation is that the
allergic inflammation that causes atopic dermatitis may make the
airways of the lungs more prone to inflammation as well.
Coughing can be a symptom
of several maladies, including heartworm disease, chronic obstructive pulmonary disease,
allergic bronchitis, cardiomyopathy, congestive heart disease, lung cancer, and several other pathologies that can affect the upper and lower
airways.
Allergic bronchitis is the narrowing
of the
airways due to inflammation and swelling
of the bronchi caused by exposure to an allergen.
A severe
allergic reaction will result in the swelling
of the actual
airway.
This could a an
allergic reaction, with the speed
of the swelling and that it is causing coughing; I would recommend visiting your Veterinarian as swelling may cause
airway obstruction.
Answer: I Cant Recommend A Prescription Antibiotic Unless Your Pet Has Local Vet Exam To Evaluate For Many Possible Causes
Of Underlying Cough From Infection To Parasite, To Inflammatory,
Allergic Airway Disease, Collapsing Trachea, Etc..
Criteria Description PRIORITY Carcinogenicity Potential to cause cancer Endocrine Disruption Potential to negatively effect hormone function and impact development Mutagenicity Potential to damage DNA Teratogenicity Potential to harm fetus Reproductive Toxicity Potential to negatively impact reproductive system ADDITIONAL Acute Toxicity Potential to cause harm upon initial, short term exposure Chronic Toxicity Potential to cause harm upon repeated, long - term exposures Irritation
of Skin and Mucous Membranes Potential to irritate eyes, skin, and respiratory system Sensitization Potential to cause
allergic reaction upon exposure to skin or
airways Other Any additional characteristic (e.g., flammability, skin penetration potential, etc.) relevant to the overall evaluation but not included in the previous criteria