Not exact matches
In the study, analysis
of patient samples demonstrated that high LSC17 scores meant poor outcomes with current standard treatment, even for patients who had undergone
allogeneic stem cell transplantation.
Of these 34 patients, 13 (38 %) have remained in remission for five years, and an additional two patients whose disease did not progress after BV went on to achieve remission after receiving
allogeneic stem cell transplant (in which healthy
stem cells are taken from a donor and administered to the patient).
As a result, they are currently being investigated as a cellular therapeutic for the treatment
of autoimmune diseases and long - term patient and graft survival following solid organ transplantation, and
allogeneic hematopoietic
stem cell transplantation.
Sioud M, Mobergslien A, Boudabous A, Fløisand Y. Evidence for the involvement
of galectin - 3 in mesenchymal
stem cell suppression
of allogeneic T -
cell proliferation.
Mehta J, Gordon LI, Tallman MS, et al., Does younger donor age affect the outcome
of reduced - intensity
allogeneic hematopoietic
stem cell transplantation for hematologic malignancies beneficially?
Immunosuppressive effect
of mesenchymal
stem cells favors tumor growth in
allogeneic animals.
Allogeneic Sibling Donor Peripheral Blood
Stem Cells Transplantation With Myeloablative Conditioning for Chronic Myeloid Leukemia in Blast Crisis - Successful Treatment Despite Severe Phase
of the Disease
In close collaboration with universities and physicians world - wide, our comprehensive investigational
stem cell treatments employ well - targeted combinations
of allogeneic human umbilical cord
stem cells, autologous bone marrow
stem cells, and autologous adipose
stem cells for the diseases listed below.
Allogeneic mesenchymal
stem cell infusion for treatment
of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS - IH).
Horwitz et al 79 reported that donor MSC contributed to bone remodelling after
allogeneic stem cell transplantation (SCT) in 3 children with osteogenesis imperfecta, a rare genetic disorder
of type I collagen.
One promising solution to increase long - term overall survival has been in the area
of allogeneic hematopoietic
stem cell transplantation (HCST).
In the future, outpatient blood and bone marrow
stem cell transplantation will be offered to a broader group
of patients with other blood disorders and for
allogeneic transplants (transplant from non-twin donor
stem cells).
Use
of a lower dose
of rabbit anti — T - lymphocyte globulin (ATLG) was superior to a higher dose in children with hematologic malignancies undergoing
allogeneic hematopoietic
stem cell transplantation (HSCT) from an unrelated donor, according to the results
of a study published in Lancet Oncology.
Allogeneic stem cell transplantation to leukaemic patients, in which the patient's own diseased bone marrow is replaced by healthy donor material, is one
of the best - established and most effective immunological therapies.
Allogeneic cell therapies involving primary
cell types such as bone marrow mesenchymal stromal /
stem cells (BM - MSCs), hematopoietic
stem and progenitor
cells (HSPCs), and T and natural killer (NK)
cells for immunotherapy applications are especially challenging because
of the vigorous process
of screening...
• Patients must have adequate coagulation (international normalized ratio (INR) or prothrombin time (PT), partial thromboplastin time (PTT) ≤ 1.5 times ULN) • Adequate liver function (total bilirubin ≤ 1.5 times the ULN, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 times ULN Exclusion Criteria: • Presence
of active / uncontrolled central nervous system involvement • History
of clinically significant cardiac disease; uncontrolled hypertension • Left ventricular ejection fraction (LVEF) < 45 % •
Allogeneic stem cell transplant within 100 days before first dose
of study drug • Known history
of human immunodeficiency virus (HIV) infection • Chronic or active hepatitis B or C, requiring antiviral therapy • Evidence
of history
of bleeding disorder, dialysis, or coexisting cancer that is distinct in primary site or histology from the cancer evaluated in this study • Serious, uncontrolled infection • Unresolved chronic toxicity > grade 1 from prior therapy • Use
of strong CYP3A4 inhibitors or strong inducers within 7 days prior to the start
of study treatment and for the duration
of the study
Patients receive one
of two types
of stem cell - based transplants: autologous, in which a patient donates and receives back his / her own
stem cells; or
allogeneic, in which bone marrow - derived
stem cells come from a related or unrelated donor whose human leukocyte antigens (HLA) are genetically matched with those
of a patient.
Low - Dose ATLG Prevents GVHD in Pediatric Hematologic Malignancies: A newly published randomized phase III study
of pediatric patients showed lower doses
of rabbit anti — T - lymphocyte globulin (ATLG) was superior to a higher dose in children with hematologic malignancies undergoing
allogeneic hematopoietic
stem cell transplantation from an unrelated donor.
Ponatinib Extends Survival Over Transplant in Chronic Phase CML: The results
of a new study that included patients from the PACE trial and the European Bone Marrow Transplant registry revealed that treatment with ponatinib yielded better overall survival (OS) compared with
allogeneic stem cell transplantation (allo - SCT) in patients with chronic phase chronic myeloid leukemia (CP - CML) with a T315I mutation.
Burmeister DM, Stone R, Wrice N, et al., Delivery
of Allogeneic Adipose
Stem Cells in Polyethylene Glycol ‐ Fibrin Hydrogels as an Adjunct to Meshed Autografts After Sharp Debridement
of Deep Partial Thickness Burns.
If these results are confirmed and one or more
of these FLT3 - targeted drugs become approved by the FDA, testing for the FLT3 biomarker may eliminate the need for thousands
of patients to undergo
stem cell transplantation (each
allogeneic transplant costs hundreds
of thousands
of dollars and place recipients at grave risk
of infection and other complications such as Graft vs. Host disease).
Review
of «Delivery
of Allogeneic Adipose
Stem Cells in PEG - Fibrin Hydrogels as an Adjunct to Meshed Autografts After Sharp Debridement of Deep Partial Thickness Burns» from STEM CELLS Translational Medicine by Stuart P. Atki
Stem Cells in PEG - Fibrin Hydrogels as an Adjunct to Meshed Autografts After Sharp Debridement of Deep Partial Thickness Burns» from STEM CELLS Translational Medicine by Stuart P. Atk
Cells in PEG - Fibrin Hydrogels as an Adjunct to Meshed Autografts After Sharp Debridement
of Deep Partial Thickness Burns» from
STEM CELLS Translational Medicine by Stuart P. Atki
STEM CELLS Translational Medicine by Stuart P. Atk
CELLS Translational Medicine by Stuart P. Atkinson
He established the Long Term Transplant Clinic at Vanderbilt in 2006, which allows for systematic multidisciplinary follow up
of patients after
allogeneic stem cell transplant.
Thus, one can transplant fully
allogeneic hematopoietic
stem cells and co-transplant, for example, hearts from the hematopoietic
stem cell donor to induce lifelong donor - specific acceptance
of the transplant, without deleterious immunosuppression [4].
Acute myeloid leukemia (AML) is the leading cause
of leukemia mortality in the United States.1 Curative treatment involves intensive induction chemotherapy, before proceeding to either consolidation chemotherapy or
allogeneic stem cell transplantation based on the patient's risk for relapse.2 This approach has been employed for > 4 decades and, although most individuals achieve complete remissions with front - line therapy, 3 the majority
of patients ultimately relapse with drug - resistant disease, and overall survival rates remain disappointingly poor.4 The limited ability
of many patients to tolerate the intense chemotherapy - based treatments, in particular hematological toxicity, further contributes to the poor outcomes noted in this disease.
Macmillan, 2014; Holler, E., et al. «Metagenomic analysis
of the stool microbiome in patients receiving
allogeneic stem cell transplantation: Loss
of diversity is associated with use
of systemic antibiotics and more pronounced in gastrointestinal graft - versus - host disease.»