The present study is informed by the theory
of allostatic load to examine how multiple stress responsive biomarkers are related to mental health outcomes.
The concepts
of allostatic load and allostatic processes can help psychologists understand how health trajectories are influenced by stressful childhood experiences in the family.
Developmental markers
of allostatic load: Examining the evidence in a longitudinal sample of kindergarten children
Schore's regulation theory: Maternal - infant interaction in the NICU as a mechanism for reducing the effects
of allostatic load on neurodevelopment in premature infants
This study will collect data using standardised measures on HRQOL and behaviours of children as well as on HRQOL, mental health and stress levels of parents along with physiological tests
of allostatic load and telomere length.
The goal of this study was to examine whether growth delay can serve as an index
of allostatic load during early development, as it is well known that the activity of stress - mediating systems inhibits growth.
Guided by an evolutionary model
of allostatic load, this study examined the hypothesis that the association between interparental aggression and subsequent changes in children's cortisol reactivity to interparental conflict is moderated by their temperamental dispositions.
The impact
of allostatic load on maternal sympathovagal functioning in stressful child contexts: Implications for maladaptive parenting.
Growth delay as an index
of allostatic load in young children: Predictions to disinhibited social approach and diurnal cortisol activity.
Higher Adherence to a Diet Score Based on American Heart Association Recommendations Is Associated with Lower Odds
of Allostatic Load and Metabolic Syndrome in Puerto Rican Adults
Role
of allostatic load and health behaviours in explaining socioeconomic disparities in mortality: a structural equation modelling approach
«Weathering» and age patterns
of allostatic load scores among blacks and whites in the United States.
This leads to the kind
of allostatic response that is positive, anabolic, ultimately balancing pro- and anti-inflammatory pathways.
Not exact matches
Marital Conflict,
Allostatic Load, and the Development
of Childrens Fluid Cognitive Performance.
Science is demonstrating the relevance
of concepts like
allostatic load, genetic snps, dysbiosis, and nutrient deficiency that render a pregnancy full
of ultrasounds the loading
of a gun shot by that Hepatitis B vaccine at birth, or perhaps 8 at a catch up visit a year later.
The researchers conclude, «Further prospective studies
of the relation between reaction time and mental health outcomes in other samples are needed to gauge whether reaction time is a true risk factor for mental disorders and to confirm the mediating roles played by smoking and
allostatic load.»
The researchers were also interested in assessing the role
of the cumulative effects
of stress over time, or «
allostatic load.»
The so - called «
allostatic load,» ie, the imbalance between the ability to adapt to environmental demands and overexposure to environmental stress, increase the risk
of cardiometabolic diseases via neuroendocrine, autonomic, and immune mediators (see section V.P)(111).
Assessment
of oxidative stress /
allostatic load — An index
of oxidative stress and
allostatic load is the amount
of ascorbates —
of buffered, natural vitamin C — based on individual «C Cleanse».
''... we hypothesize that repeated stress - related
allostatic overload may affect brain function at three basic levels: (a) at the cellular level, it may compromise proteostasis (e.g. tau protein), organelles homeostasis, and induce epigenetic changes in neuronal DNA; (b) at the tissue level it may affect intracellular communication (synaptic contacts), number
of cells (reduction
of neuronal density), composition
of the extracellular matrix (accumulation
of amyloid plaques), and neuroinflammation; (c) at the systemic levels it may alter the brain's regulation
of behavior (cognitive decline).
For, to me, it leads us to the powerfully positive message that, by following the
allostatic load guidelines that suggest we take the approach
of both reducing cumulative environmental load and optimizing
allostatic response mechanisms that revolve around hormones such as cortisol, epinephrine, and insulin plus the cardiovascular, gastrointestinal, detoxification, and immune systems, we can make major inroads in reducing human suffering.
It can be hypothesized, that in predisposed individuals...,
allostatic overload may participate in the development
of AD - related neuropathology as well.»
Mravec et al (3) next discuss Alzheimer's disease / senile dementia in terms
of a subject near and dear to my heart, as evidenced by my many writings and lectures on the subject over the years,
allostatic load.
''... chronic, stress - induced repeated activation
of the LC may lead to an
allostatic overload
of the de-toxicant capacity
of LC neurons.
We hypothesize that
allostatic overload may also participate in the development
of AD indirectly via induction
of alterations in peripheral tissues and organs.
So, though I'm mindful that I've got a starting line to get ready for in a little over two months, which means just one more month
of big training because we taper, I've got to be mindful
of not just miles, minutes, and workout goals, I've got to be sure I'm factoring in the total stress load - which is the
allostatic load — and if that scale is tipped too far for too long I could wipe out positive effects
of training.
Therefore, I was pleased to find a paper that addresses this ailment from a metabolic,
allostatic load point
of view, the recently published paper (February 2018) «Aging and Parkinson's disease: Inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis» by Calabrese et al (1).
Rather «badness» is a matter
of dosage, with low doses actually being beneficial because
of the positive, low - grade, anabolic
allostatic response they engender.
It is my hope that this
allostatic load, systems - based, functional medicine examination
of the problem will give you some insights on how you may assist some who are already suffering and how you can certainly assist those who may currently be asymptomatic but prone to development.
Therefore, whether the
allostatic response functions positively or negatively is largely a matter
of degree or dosage.
In the next quote Calabrese et al (1) continue this fascinating and controversial discussion on the idea that small
of amounts
of «toxic» substances can promote health by optimizing
allostatic, adaptive response elements by addressing what are known as «hormetins»:
Exercise treatment for bipolar disorder: potential mechanisms
of action mediated through increased neurogenesis and decreased
allostatic load
Protective and damaging effects
of mediators
of stress: Elaborating and testing the concepts
of allostasis and
allostatic load.
Batteries
of biomarkers that measure
allostatic load (also termed
allostatic overload to highlight pathophysiology
of the extreme)(38) tap into the major mediators
of allostasis along with some key secondary outcomes, such as body mass index or waist — hip ratio and glycosylated hemoglobin (39), and provide a broad - based assessment
of the dysregulation
of these adaptive systems that has turned out to have predictive value in a variety
of epidemiologic studies (40).
McEwen has characterized these accumulated risks as «
allostatic load:» As physiological systems fluctuate to meet the demands posed by a stressful environment, physiological costs
of chronic exposure to recurring or heightened neural or neuroendocrine responses to repeated or chronic stress accumulate, resulting in interacting dysregulations in multiple physiological systems (10).
While Reactive bursts can be adaptive, especially under the conditions in which our ancestors evolved, chronic Reactive states create significant
allostatic load as well as a lot
of unnecessary anxiety, irritation, frustration, drivenness, envy, interpersonal disturbances, and shame.
The framework
of allostasis and
allostatic load is supported in that examination
of multiple biomarkers working together in concert was
of value in understanding mental health problems concurrently and longitudinally.
These interactive models involving polyphenotypic options are distinct from unilateral uniphenotypic ones
of combined vulnerabilities and adversities (diathesis - stress,
allostatic load).
Elaborating and testing the concepts
of allostasis and
allostatic load