Sentences with phrase «of alternative splicing»

Studies in Biology at University of Bern, Switzerland; PhD on regulation of alternative splicing at the Karolinska Intitute, Stockholm, Sweden and at Uppsala University, Sweden; Postdoc on post-transcriptional mRNA surveillance at Brandeis University, Boston, USA; research group leader (since 2000) and full professor (since 2010) at the University of Bern, working on mRNA surveillance, turnover and splicing.

The researchers used Schizophyllum commune as a model for their study of the functional consequences of the products of alternative splicing in fungi.

To that end, Reinders and his colleague Prof. Han Wösten from Utrecht University began a research project into the products of alternative splicing in fungi.

«Our findings represent the first example of alternative splicing associated with Bt resistance that evolved in the field,» said Fabrick, who is also an adjunct scientist in the Department of Entomology at UA.

These mutated RNAs accumulate and alter regulation of alternative splicing of numerous genes.

Global analysis of alternative splicing differences between humans and chimpanzees.

However, its extreme length (> 13kb), number of exons (> 50) and high level of alternative splicing means CACNA1C isoform structure and expression is poorly understood, making it difficult to identify which gene isoforms confer disease risk and where they are expressed.

Hiller M *, Huse K *, Szafranski K, Jahn N, Hampe J, Schreiber S, Backofen R, and Platzer M. Widespread occurrence of alternative splicing at NAGNAG acceptors contributes to proteome plasticity.

While this phenomenon is known to increase complexity at the transcriptome level, the effect of alternative splicing on the complexity at the proteomic level remains controversial.

In cells, U1 snRNP plays multiple roles in processing RNA including the process of alternative splicing, by which one gene can make instructions for two or more proteins.

A key regulator of alternative splicing is the Rbfox family of proteins, which are enriched in neurons and previously were linked to neurodevelopmental disorders, including autism, schizophrenia, and epilepsy.

Use of this alternative splice site yields a transcript with an in - frame 21 base pair deletion that deletes 7 amino acids from the translated protein.

BRAF mRNA alternative splicing is a mechanism of resistance to targeted therapy.The aim of this study is to evaluate the impact of alternative splicing in patients treated with BRAF and MEK inhibitors and to assess the efficacy of splicing modulators in overcoming this resistance mechanism.

These include molecular evolution of transcription factors or changes in transcriptional regulation (Enard et al., 2002; Konopka et al., 2009), accelerated evolution of small non-coding RNAs (Pollard et al., 2006), changes in the tissue - specificity of enhancer elements (McLean et al., 2011; Prabhakar et al., 2008), or changes in patterns of alternative splicing of specific genes (Calarco et al., 2007).

HITS - CLIP, together with analysis of knockout mice and bioinformatic approaches, led to the discovery that the position of protein binding in the messenger RNA is a prime determinant of the outcome of alternative splicing or polyadenylation, general rules applicable to many splicing factors.

We investigated cases of alternative splicing by retaining all the multi-exonic receptor gene models and counted the number of alternative isoforms produced.

Sequencing the RNA in a biological sample can unlock a wealth of information, including the identity of bacteria and viruses, the nuances of alternative splicing or the transcriptional state of organisms.

To bypass the challenge, the team relied on their complementary expertise in genome engineering, stem cell differentiation into neurons, and genomic analysis of alternative splicing.

The researchers» findings contribute to the mechanistic understanding of how the machinery required to initiate and propagate action potentials of neurons are controlled at the level of alternative splicing — a very tiny piece of the neuronal maturation puzzle, but one that has a significant impact.

«Deviant alternative splicing, or mutations in the products of alternative splicing, have been tied to cancer, autism and serious development disorders, both in mice and in humans.

Yang — whose essay described examples of alternative splicing, a process by which the same stretch of DNA and its complementary messenger RNA can be spliced together in different ways and thus be translated into different proteins — will receive a $ 1000 prize.

15/3: 30 Tissue - specific transcriptome - wide networks reflect joint regulation of alternative splicing and gene expression.

Lue, whose essay described the regulation of alternative splicing and how defects in this process can cause disease, and Mueller, whose essay described examples of alternatively spliced proteins coded by the same gene with different functions that act in different cells, will each receive a $ 400 prize, and their science teachers, Dr. Martina Davies and Mrs. Jessica Graham respectively, will each receive a $ 400 grant for genetics materials.