Sentences with phrase «of alternative splicing at»

Studies in Biology at University of Bern, Switzerland; PhD on regulation of alternative splicing at the Karolinska Intitute, Stockholm, Sweden and at Uppsala University, Sweden; Postdoc on post-transcriptional mRNA surveillance at Brandeis University, Boston, USA; research group leader (since 2000) and full professor (since 2010) at the University of Bern, working on mRNA surveillance, turnover and splicing.

Not exact matches

But parts of each of four exons in Dscam can become active separately, at different times — a process called alternative splicing.

To peel away at the intricate layers that govern the development of neurons, a research team led by Chaolin Zhang, PhD, Assistant Professor in Systems Biology and Biochemistry and Molecular Biophysics and Hynek Wichterle, PhD, Associate Professor in Pathology & Cell Biology, Neuroscience, and Neurology, at the Center for Motor Neuron Biology and Disease, Columbia University Medical Center, focuses on a level of molecular regulation called alternative splicing.

The researchers» findings contribute to the mechanistic understanding of how the machinery required to initiate and propagate action potentials of neurons are controlled at the level of alternative splicing — a very tiny piece of the neuronal maturation puzzle, but one that has a significant impact.

«Our findings represent the first example of alternative splicing associated with Bt resistance that evolved in the field,» said Fabrick, who is also an adjunct scientist in the Department of Entomology at UA.

Multiple transcripts arising from alternative initiation or polyadenylation sites, or alternative RNA splicing at a single locus were not considered as multiple genes but as variants of a single transcription unit.

While this phenomenon is known to increase complexity at the transcriptome level, the effect of alternative splicing on the complexity at the proteomic level remains controversial.

«The investigational compounds used in this study represent the first orally available SMN2 splicing modifiers for SMA,» commented Stuart W. Peltz, CEO of PTC Therapeutics, Inc. «Using the experience and expertise in RNA biology we have gained at PTC over the last 16 years, we used our alternative splicing technology to identify and subsequently optimize investigational compounds that target the SMN2 splicing to produce the SMN protein.

psq is a large and complex locus, which, through the use of three alternative promoters and alternative splicing, gives rise to at least 12 different transcripts (FlyBase; Weber et al. 1995; Horowitz and Berg 1996; Ferres - Marco et al. 2006).