Sentences with phrase «of alternative splicing of»

These include molecular evolution of transcription factors or changes in transcriptional regulation (Enard et al., 2002; Konopka et al., 2009), accelerated evolution of small non-coding RNAs (Pollard et al., 2006), changes in the tissue - specificity of enhancer elements (McLean et al., 2011; Prabhakar et al., 2008), or changes in patterns of alternative splicing of specific genes (Calarco et al., 2007).

These mutated RNAs accumulate and alter regulation of alternative splicing of numerous genes.

Not exact matches

Importantly, genetic modifications blocking alternative splicing of Cdc42 in mice result in incorrectly formed axons and dendrites and, ultimately, structural and behavioural abnormalities.

However, to what extent alternative splicing increases the number of functionally important proteins in individual neurons remains an open question.

In fact, he and his community of researchers in alternative RNA splicing — a field he helped to create — have shown that they can do world - class research despite tight government budgets and three - month delivery times for reagents that can cost three times as much as they would in the United States or Europe.

Like Kornblihtt's lab, alternative RNA splicing makes use of constrained resources in innovative ways.

One way to get many types of cells or proteins from the same genetic starting material is by mixing and matching different parts of one gene to produce multiple gene readouts, a phenomenon known as alternative splicing.

In cells, U1 snRNP plays multiple roles in processing RNA including the process of alternative splicing, by which one gene can make instructions for two or more proteins.

The two closely related regulatory genes are active in the normal development of mammals and govern how RNAs produced from the genes are joined to make final versions of the encoded protein, a process called alternative splicing.

Alternative splicing was long considered a rare hiccup during transcription, but researchers have concluded that it may occur in half — some say close to all — of our genes.

In addition, the total amount of a protein can be regulated by alternative splicing, which is illustrated in the current work by using the general transcription factor TBP (TATA - box binding protein) as an example.

«The alternative splicing of more than 100 genes reacts extremely sensitively to changes in temperature, so that different proteins are produced depending on the time of day and body temperature,» said Prof. Dr. Florian Heyd.

Of particular interest is a possible association of temperature - dependent alternative splicing with the immune response during an infection with feveOf particular interest is a possible association of temperature - dependent alternative splicing with the immune response during an infection with feveof temperature - dependent alternative splicing with the immune response during an infection with fever.

In this case the temperature - dependent alternative splicing changes a non-coding region of the TBP mRNA, thereby regulating the efficiency with which the TBP protein is synthesized.

This is an alternative splicing model of the cardiac sodium channel (SCN5A) in myotonic dystrophy.

Choudhury and colleagues designed a series of experiments to find that DAZAP1 binds to a number of other proteins in the cell nucleus and promotes alternative splicing.

«While gene duplication and alternative splicing are typically invoked as major mechanisms underpinning protein neofunctionalization, this study suggests that the process of co-option should be re-evaluated as a potentially important method by which genes can acquire novel functions.»

But parts of each of four exons in Dscam can become active separately, at different times — a process called alternative splicing.

As a postdoc in the lab of Zefeng Wang, PhD, a member of the UNC Lineberger Comprehensive Cancer Center, Choudhury stumbled upon DAZAP1 while searching for proteins involved in alternative splicing — when a single gene organizes its genetic code to create different proteins with various functions.

In eukaryotes, almost all genes undergo alternative splicing, in which a precursor form of mRNA is cut and re-stitched together in numerous different combinations.

A gene can code for different proteins — with diverse functionality — through the genetic mechanism of alternative splicing (the cutting and rejoining of genes).

To bypass the challenge, the team relied on their complementary expertise in genome engineering, stem cell differentiation into neurons, and genomic analysis of alternative splicing.

To peel away at the intricate layers that govern the development of neurons, a research team led by Chaolin Zhang, PhD, Assistant Professor in Systems Biology and Biochemistry and Molecular Biophysics and Hynek Wichterle, PhD, Associate Professor in Pathology & Cell Biology, Neuroscience, and Neurology, at the Center for Motor Neuron Biology and Disease, Columbia University Medical Center, focuses on a level of molecular regulation called alternative splicing.

Alternative splicing is a process of generating multiple transcripts and protein variants by joining different combinations of coding segments.

The researchers» findings contribute to the mechanistic understanding of how the machinery required to initiate and propagate action potentials of neurons are controlled at the level of alternative splicing — a very tiny piece of the neuronal maturation puzzle, but one that has a significant impact.

A key regulator of alternative splicing is the Rbfox family of proteins, which are enriched in neurons and previously were linked to neurodevelopmental disorders, including autism, schizophrenia, and epilepsy.

«Deviant alternative splicing, or mutations in the products of alternative splicing, have been tied to cancer, autism and serious development disorders, both in mice and in humans.

«Our findings represent the first example of alternative splicing associated with Bt resistance that evolved in the field,» said Fabrick, who is also an adjunct scientist in the Department of Entomology at UA.

Clariom D Pico assays allow discovery of coding and noncoding genes, exons, and splicing events, including rare transcripts, expanding the potential for finding novel biomarkers missed by alternative techniques.

In the PNAS paper, the scientists demonstrated their method on two genomics problems, the role of gene enhancers in the fruit fly embryo and alternative splicing in a human - derived cell line.

The researchers learned that the astonishing diversity of cadherin in pink bollworm from India is caused by alternative splicing, a novel mechanism of resistance that allows a single DNA sequence to code for many variants of a protein.

Revealing functional networks of alternative splicing regulation in cancer (Valcárcel's group, Mol Cell 2013; Mol Cell 2015a: Mol Cell 2015b).

It is estimated that of the approximately 25,000 genes in the human genome, approximately 90 % have alternative splice forms.

I do like that the authors performed RNA - Seq of the transcriptome, which provides insights into mechanisms like alternative splicing (AS), allele - specific expression (ASE), and RNA editing.

Adrian R. Krainer Posttranscriptional control of gene expression; pre-mRNA splicing mechanisms, fidelity and genetic diseases; alternative splicing; RNA - protein interactions; cancer

Examination of copy number variants, alternative splicing, epigenetics and genetic variants are needed to characterise the interactions between heritable and non-heritable mutations for an insight into the full genomic complexity of these little - understood disorders.

However, its extreme length (> 13kb), number of exons (> 50) and high level of alternative splicing means CACNA1C isoform structure and expression is poorly understood, making it difficult to identify which gene isoforms confer disease risk and where they are expressed.

In some cases, alternative splicing of RNA results in the production of proteins that are involved in disease.

Tra2ß Protein Is Required for Tissue - specific Splicing of a Smooth Muscle Myosin Phosphatase Targeting Subunit Alternative Exon.

Studies in Biology at University of Bern, Switzerland; PhD on regulation of alternative splicing at the Karolinska Intitute, Stockholm, Sweden and at Uppsala University, Sweden; Postdoc on post-transcriptional mRNA surveillance at Brandeis University, Boston, USA; research group leader (since 2000) and full professor (since 2010) at the University of Bern, working on mRNA surveillance, turnover and splicing.

Use of this alternative splice site yields a transcript with an in - frame 21 base pair deletion that deletes 7 amino acids from the translated protein.

May 07, 2007 Hui Zhu, of the Eng lab, was featured in Today's Plain Dealer Newspaper in an article highlighting her interest in alternative splicing, a molecular process that allows a single gene to produce many different proteins.

An intriguing clue to this selectivity is provided by Setola et al., who identify a truncated form of SMN1 that arises from an alternative spliced SMN1 transcript that is preferentially expressed in the axonal projections of developing motor neurons.

Resveratrol, by modulating RNA processing factor levels, can influence the alternative splicing of pre-mRNAs.

Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing.

Since November 2013, as part of SGC, Clara mainly investigates different subfamilies of kinases involved in alternative splicing through phosphorylation - mediated regulation of SR proteins activity.

Pyrvinium pamoate changes alternative splicing of the serotonin receptor 2C by influencing its RNA structure.

For example, PPAM alters the molecular composition of the serotonin receptor 2C through direct binding to the pre-mRNA causing a conformational change, which makes the regulated splice site more accessible to the splicing machinery, such promoting alternative exon inclusion [86].

(D) Diagrammatic image of four transcript isoforms that were detected as alternative splice variants resulting from a SNP in the 2nd intron of bsl1 - 2.

Multiple transcripts arising from alternative initiation or polyadenylation sites, or alternative RNA splicing at a single locus were not considered as multiple genes but as variants of a single transcription unit.