Sentences with phrase «of alternative splicing on»

While this phenomenon is known to increase complexity at the transcriptome level, the effect of alternative splicing on the complexity at the proteomic level remains controversial.

Not exact matches

«The alternative splicing of more than 100 genes reacts extremely sensitively to changes in temperature, so that different proteins are produced depending on the time of day and body temperature,» said Prof. Dr. Florian Heyd.

To bypass the challenge, the team relied on their complementary expertise in genome engineering, stem cell differentiation into neurons, and genomic analysis of alternative splicing.

To peel away at the intricate layers that govern the development of neurons, a research team led by Chaolin Zhang, PhD, Assistant Professor in Systems Biology and Biochemistry and Molecular Biophysics and Hynek Wichterle, PhD, Associate Professor in Pathology & Cell Biology, Neuroscience, and Neurology, at the Center for Motor Neuron Biology and Disease, Columbia University Medical Center, focuses on a level of molecular regulation called alternative splicing.

In the PNAS paper, the scientists demonstrated their method on two genomics problems, the role of gene enhancers in the fruit fly embryo and alternative splicing in a human - derived cell line.

Studies in Biology at University of Bern, Switzerland; PhD on regulation of alternative splicing at the Karolinska Intitute, Stockholm, Sweden and at Uppsala University, Sweden; Postdoc on post-transcriptional mRNA surveillance at Brandeis University, Boston, USA; research group leader (since 2000) and full professor (since 2010) at the University of Bern, working on mRNA surveillance, turnover and splicing.

As a proxy for splicing alteration, we computed the Shannon's entropy on the relative abundance of a gene's alternative splicing isoforms (Methods)-- higher values corresponding to more stochastic production of alternative isoforms.

From 2010 - 12, Doğtaş was part of the Kunstraum München, an art association focusing on political and conceptual art, where he organized an alternative academy called «Forms of Informal Research» (2011), and curated the first solo exhibition of Palestinian - Jordanian artist Oraib Toukan's work, entitled Splice (2012).