Then, by establishing a new method for complementation assay using JUNO - deleted eggs, the group examined the
role of amino acid residue in fertilization.
Structure - activity relationship study on artificial CXCR4 ligands possessing the cyclic pentapeptide scaffold: the
exploration of amino acid residues of pentapeptides by substitutions of several aromatic amino acids.
A parallel study was performed focusing on the exploration
of amino acid residues of cyclic pentapeptides by systematic substitutions of various aromatic amino acid residues [62].
SAR studies performed on FC131 analogues, such as modification
of the amino acid residues as well as ring structures and backbones, indicated that a defined spatial arrangement of the functional groups on the side chain is necessary for the activity of such compounds.
Comparison of amino acid residues at these positions among various mammalian melanopsins suggests that melanopsins in apes including humans have acquired and kept two residues destabilizing the bond with retinal in molecular evolution.
One enzyme, EP - B2, plays a crucial role in this process by breaking gluten proteins after glutamine residues, which comprise one -
third of all amino acid residues in gluten,» Khosla added.