Sentences with phrase «of amino acid residues of»

A parallel study was performed focusing on the exploration of amino acid residues of cyclic pentapeptides by systematic substitutions of various aromatic amino acid residues [62].

Structure - activity relationship study on artificial CXCR4 ligands possessing the cyclic pentapeptide scaffold: the exploration of amino acid residues of pentapeptides by substitutions of several aromatic amino acids.

Not exact matches

The major function of DNA is to encode the sequence of amino acid residues in proteins, using the genetic code.

They retained, for example, the amino acid residues that bind to G - tract RNA, and the researchers confirmed that, like their mammalian counterparts, each RNA - binding domain of Glo can bind to this type of RNA sequence.

This allowed them to identify the boundaries of two globular domains and to crystallize the unique C - terminal domain spanning amino - acid residues 641 to 739.

Then, by establishing a new method for complementation assay using JUNO - deleted eggs, the group examined the role of amino acid residue in fertilization.

As a result of the mutational analysis, an amino acid residue of the JUNO protein, 62th Tryptophan (W62), was determined to be essential for the interaction with IZUMO1.

In aqueous fluids, amino acid residues that have polar sidechains — components that can have a charge under certain physiological conditions or that participate in hydrogen bonding — tend to be located on the surface of the protein where they can interact with water, which has negatively and positively side charges to its molecule.

They found that the N - terminal end of the cytoplasmic tail of gp41, measuring 45 amino acid residues, lacked a regular secondary structure and was not associated with the membrane, which wraps around an HIV - 1 viral particle like the leather cover of a baseball.

The C - terminal end of the cytoplasmic tail of gp41, measuring 105 amino acid residues, was tightly associated to the membrane and had three alpha - helixes with portions that were hydrophobic and portions that were hydrophilic.

What enabled them to reach this unexpected finding is an original method that this team established, which can measure direct products of γ - secretase (peptides of 3 to 5 small amino - acid residues which were named γ - byproducts).

To do this, cinnamaldehyde binds to two residues of an amino acid called cysteine on the tau protein.

The SH3 binding sites of two SH3 binding proteins were localized to a nine - or ten - amino acid stretch very rich in proline residues.

Proteins are defined by their unique sequence of amino acid residues; this sequence is the primary structure of the protein.

Comparison of amino acid residues at these positions among various mammalian melanopsins suggests that melanopsins in apes including humans have acquired and kept two residues destabilizing the bond with retinal in molecular evolution.

The residue contained traces of some of the amino acids that make up proteins.

«NMR enabled us to obtain additional information such as which amino acid residues form salt bridges thus enhancing the stability of the fibrils,» explains Prof. Henrike Heise from Heinrich Heine University Düsseldorf and Jülich's Biomolecular NMR Center.

Furthermore, the structure elucidates the location and conformation of all 42 amino acid residues of the many individual Aβ protein molecules for the first time.

It has been observed in this pathway that a single - base missense transversion causes the replacement of valine with glutamic acid at amino acid residue 600 in BRAF that is detected in about 85 % of nevi and melanoma [32, 33].

7004.1 is an extension of 790.1 with 5 extra residues at the N - terminus.7004.2 is truncated 10 amino acids short of the end exon 1 of tat.

SAR studies performed on FC131 analogues, such as modification of the amino acid residues as well as ring structures and backbones, indicated that a defined spatial arrangement of the functional groups on the side chain is necessary for the activity of such compounds.

Mutational Insights into the Roles of Amino Acid Residues in Ligand Binding for Two Closely Related Family 16 Carbohydrate Binding Modules, Xiaoyun Su, Vinayak Agarwal, Dylan Dodd, Brian Bae, Roderick Mackie, Satish Nair, Isaac Cann, Journal of Biological Chemistry, DOI: 10.1074 / jbc.M110.168302, August 24, 2010.

Substitution of pseudokinase domain residue Val - 617 by large non-polar amino acids causes activation of JAK2

All deletion alleles eliminated the pathogenic p.K1872X mutation and restored the open reading frame of BRCA2, producing predicted proteins of residue length 3,409 to 3,212 compared with the 3,418 amino acid full - length BRCA2 protein.

Upon mTORC1 inhibition, for example by amino acid depletion, mTORC1 dissociates from the ULK complex, leading to dephosphorylation of specific residues within ULK1 and Atg13, which are normally phosphorylated by mTORC1 [123].

Colors for individual amino acids are assigned based on similar properties of residues (Table S5).

«They always include an adenosine triphosphate binding site and a set of conserved amino acid residues.

Discovered that apoE is a major ligand for the low density lipoprotein receptor by mapping the amino acid residues involved in receptor binding and defining the role of apoE in liver clearance of lipoproteins.

So far we have only been able to detect the presence of some of the simpler amino acids in our photolysis residues.

The speed comes at a cost: the high pH of the soaking solution followed by pressure cooking destroys key nutrients, including vitamins and the sulfur - containing amino acids and leaves toxic residues.

Furthermore, substituting oxygen for sulfur — causing oxidation — in sulfur - containing amino acids (including in the more rare S - adenosylmethionine) can have effects in methionine residues where the surface is exposed, causing an oxidation - reduction cycle, imparing the activity of «methionine sulfoxide reductase and the subsequent accumulation of methionine sulfoxide residues [that] are associated with age - related diseases, neurodegeneration, and shorter lifespan.»

Bivalent - sulfur containing compounds are very prone to oxidation, so of the twenty standard amino acids, C and M are the most prone to oxidation, and M undergoes oxidation more readily than C, so M residues in proteins are the most vulnerable to oxidative damage.