Today is the 70th birthday of Elizabeth Hay, an embryologist at Harvard Medical School who, through pioneering studies on regeneration
of amphibian limbs, has shed light on the cellular mechanisms that transform normal cells into tumors.
Not exact matches
There is only one group
of vertebrate that has the capacity to regenerate highly complex structures such as
limbs, jaws, tail, spinal cord, or eyes throughout their lives: the urodele
amphibians.
Once ashore, these four -
limbed vertebrates, called tetrapods, branched into an impressive range
of animals:
amphibians, reptiles, dinosaurs, birds and mammals.
Unique proteins in these
amphibians cast doubt on the existence
of any latent potential for
limb regeneration
Daley notes that when
amphibians regenerate their
limbs, they form a cluster
of primitive undifferentiated cells called a blastema.
Harrison's results demonstrated that the developing
amphibian nervous system is remarkably flexible in adapting to such novel situations, even to the point
of accelerating the growth
of nerve fibers in a host species to keep pace with the faster - growing
limb of a smaller donor species.
In basic research, you can find tapeworms who thrive in the intestine
of their animal hosts — or the
limb - generating axolotl, a water
amphibian whose very name means «water monster.»
For many centuries, inquiring minds have puzzled over the capabilities
of certain worms,
amphibians, fish and other animals to regrow
limbs and other body parts.
In 2009, Ballengée and SK Sessions published «Explanation for Missing
Limbs in Deformed
Amphibians» in the Journal
of Experimental Zoology and received international media attention from the BBC and others.