They found that when E. coli were treated with
doses of ampicillin too low to kill all of the cells, some of those left alive suffered DNA damage that was hastily — and often inaccurately — patched up.
Phage from ampicillin - treated mice tripled the
amount of ampicillin resistance, while phage from ciprofloxacin - treated mice doubled the amount of ciprofloxacin resistance.
In control diet - fed mice, a
cocktail of ampicillin, neomycin, metronidazole, and vancomycin completely blocked hepatic neutrophil and lymphocyte infiltration.
Following overnight incubation, transformed bacteria are compared to unexposed bacteria for their ability to grow in the
presence of ampicillin.
«The resistance was demonstrably reduced, even at a lower
dose of ampicillin than usually,» said co-author and corresponding group leader Kathrin Rychli.
Amoxicillin has bactericidal activity against susceptible organisms similar to
that of ampicillin.