During autopsies, researchers found that their brains had the lowest
amount of amyloid deposits and contained the most antibodies.
To determine the occurrence of Aβ peptides in the rat CSF we resorted to Aβ immunoprecipiation followed by MALDI - MS analysis, before and after the
formation of amyloid deposits.
The 37 - amino - acid polypeptide amylin is the principal
constituent of the amyloid deposits that form in the islets of Langerhans in patients with type - 2 diabetes mellitus, but its role in the pathogenesis of this disease is unresolved.