Sentences with phrase «of amyloid plaque aggregates»

In persons with the disease, the formation of amyloid plaque aggregates, a process known to cause the onset of Alzheimer's disease, prevents the Crtc1 protein from functioning correctly.

Not exact matches

A protein fragment called amyloid - beta (Aβ) is known to aggregate and create plaque in the brains of Alzheimer's patients.

Previously, researchers have shown that treating cells with neuregulin - 1, for example, dampens levels of amyloid precursor protein, a molecule that generates amyloid beta, which aggregate and form plaques in the brains of Alzheimer's patients.

Currently, Alzheimer's diagnoses rely on clinical neuropathologic assessment of amyloid - β (Aβ) peptide aggregates (plaques) and neurofibrillary tangles.

In the brains of patients with Alzheimer's, amyloid peptides aggregate to form oligomers and plaques that are thought to be responsible for the disease symptoms.

In the brains of patients with Alzheimer's disease (AD), amyloid precursor protein is broken apart, and the resulting fragments — β - amyloid peptides, or Aβ peptides — aggregate to form plaques.

Golde notes that while normal concentrations of amyloid - beta in human brains can aggregate to form plaques, that doesn't happen in the lab without help.

Therapies applying this paradigm to clear β - amyloid protein (Aβ) plaques and soluble aggregates from patients with Alzheimer's disease (AD) is an extremely active field of research, with multiple active and passive Aβ vaccines currently in human clinical trials.

Together with γ - secretase, it generates amyloid - β, a short hydrophobic peptide that aggregates extracellularly into amyloid plaques in the brain of AD patients (De Strooper et al, 1998; Vassar et al, 1999; Hardy & Selkoe, 2002).

Lilly scientists had hoped that their agent, an amyloid antibody, would soak up enough of the circulating amyloid so that there weren't enough fragments around to aggregate into the toxic plaques.

The brains of individuals having Alzheimer's have clumps of amyloid plaques which are made up of aggregates of misfolded proteins.