Sentences with phrase «of amyloid plaque deposits»

«Our study shows that both higher levels of HDL — good — and lower levels of LDL — bad — cholesterol in the bloodstream are associated with lower levels of amyloid plaque deposits in the brain,» said Bruce Reed, lead study author and associate director of the UC Davis Alzheimer's Disease Center.

Not exact matches

Previously, researchers have focused on the role of protein deposits called amyloid plaques that lodge in the brain of Alzheimer's affected people.

More than 40 illnesses known as amyloid diseases — Alzheimer's, Parkinson's and rheumatoid arthritis are a few — are linked to the buildup of proteins after they have transformed from their normally folded, biologically active forms to abnormally folded, grouped deposits called fibrils or plaques.

One look at an image of an Alzheimer's afflicted brain is unflinching testimony to the disease's cruelty: It destroys of up to 30 percent of a brain's mass, carving out ravines and depositing piles of molecular junk, most visibly amyloid plaque.

Studies in mice specially bred to have features of the disease found that DHA reduces beta - amyloid plaques, abnormal protein deposits in the brain that are a hallmark of Alzheimer's, although a clinical trial of DHA showed no impact on people with mild to moderate Alzheimer's disease.

Whether this strategy will stop Alzheimer's disease in its tracks is a big if, however, because there's still a debate over whether the b - amyloid deposited in plaques causes the brain damage seen in Alzheimer's disease, or instead is a symptom of some other underlying factor.

While approximately 80 percent of Alzheimer's disease patients also have cerebral amyloid angiopathy, or amyloid beta deposits in the brain's blood vessels that increase the risk for stroke and dementia, the predominant amyloid beta pathology is plaques.

Immunotherapy is a promising strategy for the treatment of Alzheimer's that uses antibodies to stimulate the immune system to remove pieces of a protein called amyloid beta which accumulates in the brain (in deposits known as plaques) and is thought to be a major factor driving Alzheimer's neurodegenerative effects.

«The activity of the microglia is stimulated by dying brain cells, not by the deposits of amyloid proteins, called plaques, which also occur in Alzheimer's disease,» Haass notes.

The results were remarkably positive, with the reduction in BACE1 activity not only stalling the development of amyloid plaques in the mice, but actually removing the deposits that had already formed.

Measuring tau deposits using the novel radiotracer 18F - AV - 1451 (18F - T807), in conjunction with 11C - PiB to measure amyloid plaques and 18F - FDG to measure regional neurodegeneration, offers new insight into the neurodegenerative characteristics of Alzheimer's disease and shows that tau pathology may be an instrumental target for disease - modifying strategies.

At 10 months of age the mouse models were found have no amyloid plaque deposits at all.

The researchers were looking for two specific types of protein: deposits of beta - amyloid plaque and knotted threads of tau protein tangles.

Scientists have identified a basic pathologic process underlying Alzheimer's development that involves the formation of abnormal protein deposits in the brain known as beta - amyloid plaques, but they still aren't entirely sure what causes this to happen.