Sentences with phrase «of an abnormal protein called»

Several factors have been implicated in Alzheimer's, including the build - up of an abnormal protein called beta amyloid, fibrous tangles in the brain involving abnormal forms of a protein called tau, and — most recently — an association between the disease and a gene called ApoE.

In most cases, CTE is thought to be caused by repeated blows to the head, which damage brain tissue and lead to a buildup of an abnormal protein called tau, according to the CTE Center.

Not exact matches

All these diseases share a common feature: abnormal buildup of a protein called tau in the brains of patients.

Payne keyed in the symptoms, and the computer program suggested a handful of potential conditions, including a rare disease called amyloidosis, in which abnormal proteins build up in the body, interfering with normal organ function and causing nerve damage.

People with the transthyretin amyloidosis have mutations in the DNA of the transthyretin gene, which causes abnormal buildup and deposits of a transport protein called transthyretin in nerve and heart cells.

FA is caused by reduced expression of a mitochondrial protein called frataxin (FXN) due to a two mutated or abnormal copies of the FXN gene.

According to the proposal, called the amyloid hypothesis, Alzheimer's disease, estimated to affect more than 5 million people in the United States alone, is caused by abnormal buildup of A-beta protein in the brain.

In multiple myeloma, normal plasma cells transform into malignant myeloma cells and produce large quantities of toxic abnormal immunoglobulin called monoclonal protein that can damage multiple organs.

Multiple myeloma is preceded by a blood disorder called monoclonal gammopathy of undetermined significance (MGUS) in which abnormal plasma cells produce many copies of an antibody protein.

For nearly 30 years, researchers have gathered evidence that a group of bizarre, fatal brain diseases — including mad cow and its human equivalent, Creutzfeldt - Jakob disease — are caused not by a virus or bacterium but by an abnormal form of a protein, called a prion.

The problem with making blood stem cells proliferate outside the body is that the artificial growth gives rise to an accumulation of abnormal proteins in a part of the cell called the endoplasmic reticulum, ER.

Li points out that, unlike yeast cells, human and mammalian cells have a protein called p53 that kills cells with abnormal numbers of chromosomes.

The disease is largely attributed to an abnormal buildup of proteins, which can form amyloid beta plaques and tangles in the brain that trigger inflammation and result in the loss of brain connections called synapses, the effect most strongly associated with cognitive decline.

Hutchinson - Gilford progeria is caused by a spontaneous mutation during conception in a gene called LMNA, which encodes a protein called prelamin A. Progeria patients experience a buildup of an abnormal version of prelamin A in their cells that, among other changes, distorts the nucleus and alters gene expression.

The researchers found that the ALS / FTD mutation produces an abnormal version of a protein called TIA1 that is a building block of such organelles.

Rather, the mutation produces an abnormal version of a protein involved in a process called phase separation in cells.

Alzheimer's disease, the most common form of dementia, is characterized by the accumulation of plaques (composed of amyloid - beta protein) and fibrous tangles (composed of abnormal tau) in brain cells called neurons.

When grown in a collagen gel, Madin - Darby canine kidney (MDCK) cells form into cysts, and the orientation of proteins, called polarity, are abnormal following Tuba knockdown.

Parkinson's is due to degeneration of the brain's dopamine area; parkinsonism is caused primarily by abnormal clumping of proteins called alpha - synuclein.

No genes that produce abnormal proteins were found, but instead the elevated risk appears to come from groups of tightly - linked DNA sequences called «haplotypes» that regulate the expression of protein - coding genes.