Sentences with phrase «of an estrogen receptor»

Breastfeeding may be especially helpful at reducing risk of estrogen receptor negative, including triple negative, breast cancers.

High total and saturated fat intake were associated with greater risk of estrogen receptor - and progesterone receptor - positive (ER+PR +) breast cancer (BC), and human epidermal growth factor 2 receptor - negative (HER2 --RRB- disease, according to a new study published April 9 in the Journal of the National Cancer Institute.

Melinda Wilson, an associate professor at the University of Kentucky who is studying the role of estrogen receptors in the brain, says that her group had applied for NSF funding several times.

When those babies grow up, the resulting decrease of estrogen receptors makes them less attentive to their babies.

While one drug, MEK inhibitor, is usually used in advanced - stage melanoma, the other drug, CDK4 / 6 inhibitor, palbociclib, is currently FDA - approved for treatment of Estrogen Receptor - positive breast cancer patients.

Another smaller trial of estrogen receptor imaging is underway at the Abramson Cancer Center's 2 - PREVENT Translational Center of Excellence.

Using in vitro, or test tube, experiments, the researchers applied these chemicals to human cancer cells to measure changes of estrogen receptor - and androgen receptor - target genes and transcriptional activity.

They also show increased expression of the estrogen receptor alpha [ER +] gene that drives cell division,» says Koshy.

And the third type is a translocation, in which half of the estrogen receptor gene is swapped for a completely unrelated gene from a different part of the genome.

The mice are particularly good models of estrogen receptor - positive tumors (so named because they are fueled by estrogen) that have become resistant to the drugs used to treat them.

The researchers are collaborating with investigators at the University of Pennsylvania that have found that turning on a very specific type of estrogen receptor on melanoma makes it vulnerable to immunotherapy.

Indeed, some studies have found that as estrogen levels decline in women, the number of estrogen receptors — including ER - a — falls too.

In laboratory experiments, researchers at Karolinska Institutet in Sweden demonstrate that estrogen treatment and overexpression of the estrogen receptor cause malignant neuroblastoma cells to mature into neuron - like cells.

«Our data suggests that estrogen could be a therapeutic method for patients who express high levels of the estrogen receptor,» continues Professor Arsenian - Henriksson.

In the mice, the neuron - like cells did not grow as quickly as the original cancer cells, and analyses of the tumour tissue from patients show that those with a high level of the estrogen receptor have a better survival rate that those with a low.

The new study suggests another culprit: declining levels of an estrogen receptor known as ER - a.

It is normally very sensitive to estrogen - targeting therapies because of high expression of the estrogen receptor protein, but rarely shows high expression of the HER2 protein.

miR - 148a Suppresses estrogen - induced viability and migration of breast cancer cells via inhibition of estrogen receptor a expression.

BPA is believed to exert its biological effects largely through loose occupancy of the estrogen receptor, and there are reports of both estrogen agonist [7] and androgen antagonist [8] activity.

LSD1 engages a corepressor complex for the activation of the estrogen receptor a by estrogen and cAMP.

In pulmonary lymphangioleiomyomatosis expression of progesterone receptor is frequently higher than that of estrogen receptor.

Not only is the progesterone receptor an «essential modulator of estrogen - receptor - regulated genes,» but it also significantly contributes to the «prognostic value of estrogen receptors in ER + / PR + breast cancers.»

Overweight / obese males showed accelerated aromatization of androgens to estrogens, inhibiting gonadotropin secretion by activation of estrogen receptors (ERs) of the hypothalamus that promote hypogonadism (78).

Zhu Q, Jin L, Casero RA, Davidson NE, Huang Y. Role of ornithine decarboxylase in regulation of estrogen receptor alpha expression and growth in human breast cancer cells.

Triple - negative breast cancer (TNBC), a tumor type defined by its lack of estrogen receptor, progesterone receptor, and Her2 (ERBB2) amplification, accounts for 16 % of breast cancers.

«Our anaylsis suggests that biomarkers like E-cadherin are even more important than tumor size, tumor grade, the presence of estrogen receptors or the age of the patient.»

Unfortunately, the standard tools for assessing risk of metastasis — such as the size of the tumor, its grade, the presence of estrogen receptors and the proportion of dividing cells — are «insufficient,» note the authors, «for clinical decision making.»

In particular, KMT2C / MLL3, which is mutated in about 7 % of all estrogen receptor positive breast cancers, is a histone methyltransferase that creates the H3K4me1 mark at enhancers.

Sexual responses of the male rat medial preoptic area and medial amygdala to estrogen: site specific reduction of estrogen receptor alpha.

Mark Chen: Non-nuclear Distribution of Estrogen Receptors in the Brain of the Goldfish (Carassius auratus)

Dissection of the LXXLL nuclear receptor - coactivator interaction motif using combinatorial peptide libraries: discovery of peptide antagonists of estrogen receptors alpha and beta

Dr. Mack's research has focused primarily on the use of novel antitumor agents in human estrogen receptor negative breast tumor cells, and more recently, on the use of bioflavonoids in the regulation of estrogen receptor positive (ER +) and estrogen receptor negative (ER --RRB- breast tumor cell proliferation.

Amphiregulin is an essential mediator of estrogen receptor alpha function in mammary gland development

Breast cancer cells, which survive in hypoxia, share many characteristics with breast cancer stem cells (CSC) such as loss of estrogen receptor - α (ER - α) expression (1), increased anoikis resistance (14) and increased resistance to radiotherapy and chemotherapy (15, 16).

Loss of RUNX1, a key regulator of estrogen receptor - positive luminal breast cells, impairs mammary epithelial differentiation and contributes to luminal breast cancer via genetic interactions with a loss of p53 or RB1.

A novel first - in - class small molecule (ERX - 11) that interacts with and disrupts the interactome of the estrogen receptor (ER), blocks the growth of ER - positive breast cancers, including those that are resistant to currently approved hormonal agents.

One of progesterone's functions is to restore the normal sensitivity of estrogen receptors.

Because they can bind to different portions of estrogen receptors, isoflavones can both combat estrogen dominance and address deficiencies by acting in a manner similar to the naturally - occurring form of the hormone.

In a 2009 study in the journal, Breast Cancer Research and Treatment, researchers found that dietary acrylamide intake was associated with increased risk of estrogen receptor - positive breast cancer, but the same was not found with estrogen receptor - negative breast cancer.

The androgen derivative 5alpha - androstane - 3beta, 17 beta - diol inhibits prostate cancer cell migration through activation of the estrogen receptor beta subtype..

5alpha - Androstane - 3beta, 17 beta - diol (3beta - diol), an estrogenic metabolite of 5alpha - dihydrotestosterone, is a potent modulator of estrogen receptor ERbeta expression in the ventral prostrate of adult.

«Dimethyl sulfoxide is a potent modulator of estrogen receptor isoforms and xenoestrogen biomarker responses in primary culture of salmon hepatocytes.»

With the discovery of estrogen receptor positive breast cancers came agents to block estrogen's effects, including the drug tamoxifen.

Ovarian Actions of Estrogen Receptor - β: An Update Ann E. Drummond, Ph.D. 1 Peter J. Fuller, B.Med.Sci., M.B.B.S., Ph.D., F.R.A.C.P. 1 1Prince Henry's Institute of Medical Research, Clayton, Victoria, Australia

4) Reduces the function of Estrogen Receptor Beta 5) Negatively affects mitochondrial function 6) Alters hypothalamic pituitary - gonadal axis Increases testosterone, 7) lowers progesterone, 8) alters GnRH secretion 9) Increases glucocorticoids, 10) heightens response to stress, elevates levels of anxiety

Sometimes they increase estrogenic activity — depending on the type of estrogen receptor present in this kind of tissue, say, in this case, the skin — and sometimes they increase it, like in the ovaries.

In hypothyroidism and Hashimoto's, large numbers of estrogen receptors amplify estrogen's dangerous effects.

Finally, the effects, or activity, of estrogen depends largely on the number of estrogen receptors at the tissue level.

In fact, I was just lecturing in Oregon with Dr. Tori Hudson and she said to the audience, «I hope everyone's put the soy issue debate to a close,» because soy is protective of the estrogen receptor beta, but it's a different issue with thyroid.

Clomid (Clomiphene citrate) and Nolva (Nolvadex, Tamoxifen) are structurally similar and classified as selective modulators of estrogen receptors with mixed agonistic and antagonistic properties.