Sentences with phrase «of an osteoblast cell»

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The process takes place by means of a mechanism — unveiled in this study — that inhibits the activity of the osteoblasts, the cells that produce the bone matrix so that bones can grow during childhood and youth, and remain in good condition in adulthood.

A new therapy changes the balance of osteoblasts (pictured here) and fat cells in the bone marrow, leading to stronger bones.

Varghese and her team showed that they could control the differentiation of human pluripotent stem cells into functional osteoblasts — bone - building cells — simply by adding the molecule adenosine to their growth medium.

Instead, Sen found that actin was trafficked into the nuclei of the stem cells, where it had the surprising effect of inducing the cells to become osteoblasts.

Bones need a constant new creation of cells specific to their tissue, including the bone - producing cells called osteoblasts.

Two types of cell maintain bone: osteoblasts, which create new bone tissue, and osteoclasts, which remove old tissue.

The stretched cells turned into bone - making cells called osteoblasts, Chen's team reports in the April issue of Developmental Cell.

This soluble factor was found at higher levels in the blood of animals with lung tumors, could increase the activation of osteoblasts and contributed to the maturation of neutrophils in cultured cells.

«Our findings indicate the existence of long - distance interactions between lung tumors and bones: lung tumors remotely activate osteoblasts, and those bone cells, in turn, shape immunity by supplying tumors with cancer - promoting neutrophils,» says Pittet, who is an associate professor of Radiology at Harvard Medical School.

Furthermore, since the cells responsible for synthesising new bone tissue (osteoblasts) are known to attach close to the tip, it would appear that the electric field distribution signals this point as the centre of damage, becoming a moving beacon for repair efforts as the crack is healed.

Both the number and activity of osteoblasts — cells that produce and reshape bone tissue — were increased within the bone marrow of mice with lung tumors compared with cancer - free animals; and reducing the number of osteoblasts in mice not only limited neutrophil infiltration of tumors but also interrupted tumor progression.

Dissolved metal ions were shown to reach the bone marrow, where they impair mesenchymal stromal cells (MSCs), the progenitors of osteoblasts, a type of cell that is responsible for bone mineralization.

Two nearly identical plots showing cell counts after exposure to osteoblasts (bone cells) lacking a particular protein appear in Figure 6c of the Blood paper.

Proper bone development is maintained through a fine balance of bone - forming (osteoblast) and bone - resorbing (osteoclast) cells.

Then bone - making cells called osteoblasts and bone - absorbing cells called osteoclasts grow and sculpt new bone at the site of fracture.

«Our experiments showed that restoring H19 expression hindered by too much p53 restored «protective differentiation» of osteoblasts to counter events of tumor growth early on in bone cancer,» said co-author, Ihor Lemischka, PhD, Director of The Black Family Stem Cell Institute within the Icahn School of Medicine.

The WNT7B protein had no effect on the total activity of bone - degrading osteoclasts but substantially increased the number of bone - building osteoblast cells.

Our bones are in a constant state of flux as the number of bone - making (osteoblast) cells fluctuates, while the number of bone - degrading (osteoclast) cells also adjusts.

Mineralized human primary osteoblast matrices as a model system to analyse interactions of prostate cancer cells with the bone microenvironment.

Differential osteogenicity of multiple donor - derived human mesenchymal stem cells and osteoblasts in monolayer, scaffold - based 3D culture and in vivo.

Studying the drug - responsiveness of breast cancer cells cultured within human osteoblast - derived matrices.

Both pathways appear to be responsible for the differentiation and proliferation of cell type similar to bone mass and osteoblasts (Fig. 6).

Spatial Segregation of BMP / Smad Signaling Affects Osteoblast Differentiation in C2C12 Cells.

The periosteum is a mixed cell population of fibroblasts, osteoblasts, MSCs, and pericytes cells.

Similarity between the osteoblasts and the calicoblastic epithelium cells of scleractinian coral was also shown in the localization of the protein BMP in the tissue of S. pistillata (Zoccola et al., 2009), and for its role in the coral biomineralization (Mass et al., 2016; Zoccola et al., 2009).

In addition to iPS cells derived from progeria - patients, the researchers successfully applied their method to adult mesenchymal stem cells, which can differentiate into a variety of cell types, including adipocytes, osteoblasts, chondrocytes, cardiomyocytes, and, as described lately, beta - pancreatic islets cells.

Through its various targets, MMP1 promotes not only tumor invasion but also breast cancer colonization to bone by mechanisms that include the release of membrane - bound EGF - like growth factors from tumor cells, leading to activation of EGF receptor signaling and suppression of OPG expression in osteoblasts, which in turn promotes the differentiation and activation of osteoclasts required for bone destruction and enhanced tumor growth in the bone microenvironment (32).

To evaluate whether ABL kinases might regulate the secretion of osteoblast - derived RANKL or OPG leading to osteoclast differentiation, we analyzed RANKL and OPG mRNA abundance in the murine osteoblast cell line 7F2 in response to conditioned medium from control and ABL1 / ABL2 knockdown breast cancer cells.

Depletion of ABL kinases in breast cancer cells decreased IL - 6 concentrations and was accompanied by increased OPG expression in osteoblasts.

In vitro assays of the osteoblast cultures derived from the MT1 - / - and MT2 - / - mice showed a cell intrinsic defect in the proliferation, differentiation and mineralization abilities of MT2 - / - osteoblasts compared to WT counterparts and the mutant cells did not respond to melatonin addition.

Magnesium is mitogenic (causes cell division) in osteoblasts (the major cellular component of bone) and magnesium depletion inhibits cellular growth.

The reasoning goes as follows: estrogen is a sex hormone that is essential to female bone health because it promotes the activity of osteoblasts, which are cells that produce bone.

Research has shown that strontium may play a role in the formation of osteoblasts, new bone forming cells, while at the same time slowing the breakdown of old bone by inhibiting osteoclasts.

Osteoblasts are a type of cell that creates new material to rebuild bones.

Not only does lactoferrin increase osteoblast activity, it also reduces the formation of osteoclasts, and these bone cells help to increase bone turn - over or bone loss.

There is evidence of progesterone receptors in osteoblasts (bone building cells) but not for estrogen, indicating a bone - building role for progesterone.10

Collagen peptides are known to stimulate the growth of «osteoblasts,» which are the cells responsible for bone formation.14 Preliminary studies in rats also indicate that collagen supplementation may also help increase bone mineral density.15

Progesterone, on the other hand, boosts the production and activity of cells that build new bone or osteoblasts.

Studies showed that curcumin reduced joint swelling by modifying gene expression; inhibited inflammation by regulating NF - κB, a pro-inflammatory protein; and slowed down joint destruction by decreasing activity of osteoblasts, cells involved in bone breakdown.

You would basically see an increased activity of osteoblast which is your bone building cell.

Muthusami S, Senthilkumar K, Vignesh C, Ilangovan R, Stanley J, Selvamurugan N, Srinivasan N. «Effects of Cissus quadrangularis on the proliferation, differentiation and matrix mineralization of human osteoblast like SaOS - 2 cells.»

Here's a quote: «Lactoferrin: Lactoferrin found in foods such as yogurt and kefir will stimulate new bone growth while preventing further breakdown of existing bone tissue, lactoferrin enhances both the growth and the activity of osteoblasts (the cells that build bone), and reduces the rate of bone cell death by 50 to 70 percent and decreases the development of osteoclasts, the cells responsible for breaking down bone.»

Finally, acute changes in blood calcium concentrations do not seem to elicit the secretion of the phosphaturic hormone fibroblast growth factor 23 (FGF - 23), which is produced by bone - forming cells (osteoblasts / osteocytes) in response to increases in phosphorus intake (see the article on Phosphorus)(2).

I think that probably the signs of pano or the actual development of enostosis, as some prefer to call it, in the hemophiliac dog come about via bleeding in the marrow with osteoblast (bone depositing cells) activity.

The results showed that the combination of avocado / soybean unsaponifiables (ASU), glucosamine hydrochloride, and chondroitin sulfate is effective in equine cartilage cells (chondrocytes) and bone cells (osteoblasts) at inhibiting expression and decreasing production of mediators involved in joint cartilage breakdown.