Sentences with phrase «of androgen receptors»

Reduced testosterone equals less stimulation of androgen receptors in your skin's sebaceous glands.

Insulin both encourages the creation of IGF - 1, an anabolic hormone also found in dairy, and increases the receptiveness of the androgen receptors of the sebaceous glands to DHT.

The activation of the androgen receptors stimulates the cells to boost and increase the protein production in the body that is used for

The activation of the androgen receptors stimulates the cells to boost and increase the protein production in the body that is used for ATP or energy production as well.

Without adequate amounts of zinc, the testicular cells lose the ability to convert lipids, concentration of androgen receptors decrease and levels of aromatase in the liver are inhibited.

The supplement increases the number of androgen receptors in the body that can form binding links with free testosterone molecules.

It's also been found that vitamin D increased the number of androgen receptors in the muscle cells.

People lacking zinc often exhibit impairments of their androgen receptors.

This is a result of the greater presence of androgen receptors in upper body muscles and their ability to respond better to resistance training.

«Recent data have shown that a variant of the androgen receptor called AR - V7, found in tumour cells circulating in the blood of patients with metastatic CRPC, predicted resistance to treatment with enzalutamide and abiraterone,» she will say.

A new University of Colorado Cancer Center study being presented today at the Endocrine Society Annual Meeting shows that even triple negative breast cancers expressing very low levels of androgen receptor may benefit from this therapy.

«We're still early in the study of androgen receptor in breast cancer and already scientists are divvying up the disease to say, for example, that only the high AR expressing subtype should be treated with anti-androgen receptor therapies,» Barton says.

The new research found that on top of their known effects on cancer, Hsp90 inhibition also blocked production of abnormal forms of the androgen receptor, stripping cancer cells of their defences against hormone treatments.

However, cancer cells often generate abnormal forms of the androgen receptor that can be switched on all the time without the need for androgen hormone stimulation.

AR - V7 is a truncated form of the androgen receptor (AR) that is detected in about a third of patients with castration - resistant prostate cancer.

Aberrant activation of androgen receptor in a new neuropeptide - autocrine model of androgen - insensitive prostate cancer.

Inappropriate activation of the androgen receptor by nonsteroids: involvement of the Src kinase pathway and its therapeutic implications.

Native functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy.

Express high levels of the androgen receptor, a key to testosterone production, and so are vulnerable to hormonal therapy.

This preclinical work led to the development of a novel anti-androgen ARN - 509, a small - molecule inhibitor discovered in collaboration with UCLA chemist Michael Jung, which targets the increased levels of androgen receptor found in hormone - refractory disease.

He is currently funded by the Susan G. Komen for the Cure Foundation to explore the role of androgen receptor (AR) in breast cancer subtypes.

In humans, L - carnitine helps to increase the growth of muscle cell fibers by increasing energy production within cells and by increasing the number of androgen receptor sites on the muscle cell surface, which in turn increases the level of circulating testosterone.

A candidate gene study of the androgen receptor gene enabled the detection of three alleles in the trinucleotide (CAG) repeat region in exon 1 in the Japanese Akita inu breed [100].

Not exact matches

The increase in androgen receptors increases the influence of testosterone, which further increases their confidence and eagerness to tackle future challenges.

Small victories build new androgen receptors in the areas of the brain responsible for reward and motivation.

The AR - V7 variant is formed when an androgen receptor loses the end part of the receptor, called the C - terminal end; this is deleted due to an error in RNA processing in tumour cells, leaving only the beginning part of the receptor, the N - terminal end.

Mice that won home or away showed increased expression of the receptors for the male hormone androgen in a region of the brain that influences social aggression.

For example, levels of estrogen and androgen receptors were upregulated in female - associated placentas while inflammatory markers associated with increased risk of behavioral disorders were upregulated in placentas from both sexes.

«It is telling us that the pesticides most prevalent in the human population have effects on the androgen receptor,» said Zoeller, who directs the university's Laboratory of Molecular, Cellular and Developmental Endocrinology.

The most common, found in nearly two - thirds of the samples, were abnormalities in genes responsible for the androgen receptor — a cell structure that sends growth signals in response to the male hormone androgen.

Denmeade says the combination of drugs that block testosterone production and receptors, called androgen deprivation therapy, may make prostate cancer more aggressive over time by enabling prostate cancer cells to subvert attempts to block testosterone receptors.

Using in vitro, or test tube, experiments, the researchers applied these chemicals to human cancer cells to measure changes of estrogen receptor - and androgen receptor - target genes and transcriptional activity.

On the other hand, we suspect that PCBs could provoke cancer through several mechanisms, which include the interaction with estrogen and androgen hormone receptors, the production of free radicals, or with DNA.

Will you be able to send me a listing of funding sources for research in blood disorders and funding sources for disorders of mutant androgen / steroid receptors?

A search of the CRISP database of NIH - funded research projects on three key words — mutant, androgen, and receptor — yields 24 projects funded since 1999 by nine different NIH institutes: the National Cancer Institute (eight projects), the National Institute of General Medical Sciences (NIGMS, three projects), the National Institute of Child Health and Human Development (three projects), the National Institute of Diabetes and Digestive and Kidney Diseases (two projects), and the National Center for Research Resources (two projects).

This is a small subset of all the NIH - funded research related to the work you want to do, but it is a fair sample of the diversity of androgen - receptor research within NIH.

Androgen receptors are remarkable for their diversity of roles in human disease.

They will soon publish details of how tamandron, and related but more potent compounds, bind to androgen receptors.

Such a drug would block only the androgen receptor in prostate cells, and so stop the chain of reactions leading to further tumour growth, says McCague.

McCague says tamandron has a similar structure to tamoxifen but one part of the molecule resembles testosterone (see Diagram) and this should cause it to bind specifically to androgen receptors.

This human data follows extremely promising preclinical data (much of which was reported at the previous year's San Antonio Breast Cancer Symposium) supporting the androgen receptor as a target in breast cancer.

Androgen is the generic term for any natural or synthetic compound, usually a steroid hormone, that stimulates or controls the development and maintenance of masculine characteristics in vertebrates by binding to androgen reAndrogen is the generic term for any natural or synthetic compound, usually a steroid hormone, that stimulates or controls the development and maintenance of masculine characteristics in vertebrates by binding to androgen reandrogen receptors.

But recent work shows that while these cancers lack estrogen receptors, progesterone receptors, and aren't driven by the gene HER2, up to a third of these tumors express the androgen receptor — clinical trials are underway to inhibit the androgen receptor in these tumors in much the same way that the drug Tamoxifen inhibits estrogen receptor in estrogen - receptor - positive breast cancers.

It was only when we discovered that two - thirds of triple - negative breast cancers express vitamin D and androgen receptors that we were able to treat the tumors using a hormone - receptor approach.»

«The study showed that androgen receptor has important roles in other subtypes of triple negative breast cancer as well,» Barton says.

Results showed that not only does anti-androgen receptor therapy reduce the ability of androgen - receptor - expressing triple - negative breast cancers to proliferate, migrate and invade, but for these cells, androgen receptor seems essential to survival.

A recent study by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine revealed that triple - negative breast cancer (TNBC), which has generally been unresponsive to hormone receptor - targeted treatments, can indeed be treated using vitamin D and androgen receptor - targeted therapy.

Rosenfeld's group went on to find that these cytokines trigger a relay team of molecules to alter the androgen receptor.

«We have demonstrated for the first time that Hsp90 inhibitors can block the production of the most common abnormal androgen receptors that cause many prostate cancers to stop responding to current treatments.

Androgens, like testosterone, encourage the growth of prostate cancer cells, so scientists designed drugs called selective androgen receptor antagonists / modulators (SARMs) to block androgen receptors.