Sentences with phrase «of aneuploid»

Drugs that target these pathways may have broad utility against a wide range of aneuploid cancers, while exhibiting minimal toxicity in euploid tissue.

Mutations in a deubiquitinating enzyme of S. cerevisiae, which arose during the evolution of an aneuploid isolate, leads to improved proliferation of many aneuploid strains, likely by promoting degradation of aberrant proteins produced in perturbed stoichiometric ratios [11].

Phenotypic diversity is caused by this aneuploidy, as loss of the aneuploid chromosomes restored both euploidy and the wild - type parental phenotype.

Heitman and his colleagues also used some of the aneuploid offspring to infect animal models and showed they could be just as virulent as the parent, suggesting how new properties (drug resistance) and old ones (virulence) could be combined.

Telomeres respond to aneuploidy by generating stress signals that suppress the proliferation of aneuploid cells.

The rate of aneuploid embryos resulting in miscarriage increases dramatically with maternal age such that 50 % or more of pregnancies after age 40 will miscarry.

In the embryology lab, at the earliest days of embryo development, most of these aneuploid embryos don't develop, and are never seen clinically.

Examples of aneuploid embryos include trisomy 18 and trisomy 21, otherwise known as Down Syndrome.

Not exact matches

Miscarriage occurs in about a fourth of pregnancies — most of these are aneuploid.

Half or more (sometimes all) embryos in a particular IVF treatment cycle are aneuploid, and while we can't prove this, we suspect that the majority of natural conceptions are affected by aneuploidy as well.

In a woman under age 30, half of embryos are aneuploid.

An embryo that carries an abnormal number of chromosomes is «aneuploid».

In a retrospective analysis of clinical trial data, they found that melanoma patients with highly aneuploid tumors were less likely to benefit from immune checkpoint blockade therapy than patients whose tumors showed fewer chromosomal disruptions.

In short, the suddenly awakened cells displayed massive genomic instability, quite beyond their simple aneuploid condition at the start of the experiments.

«We think this rapid evolution could allow the aneuploid cells to acquire some of the pro-cancer characteristics that might promote cancer development or cause a cancer in a person to proliferate,» Sheltzer says.

Having an irregular number of chromosomes, almost by definition, leads to imbalances in the numbers of proteins expressed in aneuploid cells.

Further CGH analysis showed that two of these strains were aneuploid (Figure 9B).

Cells isolated from lungs of infected animals exhibited relatively stable aneuploid phenotypes and were found to retain their aneuploid chromosome in 70 — 80 % of isolates based on multiplex PCR [20 isolates were analyzed from each strain, 15 were aneuploid for MN35 (75 %), 16 for MN55 (80 %), 14 for MN77 (70 %), and 15 for MN89 (75 %)(Figure S9)-RSB-.

Thus, under the stressful gauntlet of the host, several aneuploid progeny appeared as fit as the euploid parent whereas others were attenuated.

Mice were infected with the aneuploid strains via intranasal instillation and monitored for signs of pulmonary cryptococcosis or meningoencephalitis.

Consistent with the observed consequences of aneuploidy in S. cerevisiae, all aneuploid C. neoformans strains in our study exhibited a TS phenotype (Figure 3A).

We have also identified a transcriptional signature of aneuploidy that is associated with cellular stress and slow proliferation, and is found in aneuploid primary and cancer cells across a host of organisms.

We demonstrated that aneuploidy can function as a novel source of genomic instability, as aneuploid cells tend to display elevated levels of mutation, mitotic recombination, and chromosome loss.

We're working to understand how aneuploidy impacts cancer progression, in hopes of developing therapies that can specifically eliminate aneuploid cancers while leaving normal cells unharmed.

Moreover, many human tumors have highly abnormal numbers of chromosomes (that is, they are aneuploid), with initial chromosomal loss participating in the early steps of the transformation cascade in inherited cancers caused by heterozygous mutation in tumor suppressor genes and the more widespread aneuploidy characteristic of advance tumors thought to drive acquisition of malignant growth properties.??

Wing primordia subjected to CIN are characterised by tumor - like overgrowths, metastatic behavior and malignancy to the host upon blockade of the apoptotic machinery, and this tumorigenic response relies mainly on the production of highly aneuploid cells that delaminate from the epithelium and activate a JNK - dependent transcriptional response.

Using a series of genetically - matched euploid and aneuploid cell lines, we have demonstrated that aneuploidy can paradoxically function as a barrier to tumor growth.

Cole Laboratory publishes new paper in Cell (10/19/2017)- Chromosome mis - segregation creates cells with the wrong number of chromosomes (aneuploid cells).

We are particularly interested in the mechanism of chromosome pairing and the quality control of the crossover formation process, and we aim to understand how the formation of gametes with abnormal / aneuploid genome is minimized in mammals.