Sentences with phrase «of aneuploid cells»

Telomeres respond to aneuploidy by generating stress signals that suppress the proliferation of aneuploid cells.

Not exact matches

In short, the suddenly awakened cells displayed massive genomic instability, quite beyond their simple aneuploid condition at the start of the experiments.

«We think this rapid evolution could allow the aneuploid cells to acquire some of the pro-cancer characteristics that might promote cancer development or cause a cancer in a person to proliferate,» Sheltzer says.

Having an irregular number of chromosomes, almost by definition, leads to imbalances in the numbers of proteins expressed in aneuploid cells.

Cells isolated from lungs of infected animals exhibited relatively stable aneuploid phenotypes and were found to retain their aneuploid chromosome in 70 — 80 % of isolates based on multiplex PCR [20 isolates were analyzed from each strain, 15 were aneuploid for MN35 (75 %), 16 for MN55 (80 %), 14 for MN77 (70 %), and 15 for MN89 (75 %)(Figure S9)-RSB-.

We have also identified a transcriptional signature of aneuploidy that is associated with cellular stress and slow proliferation, and is found in aneuploid primary and cancer cells across a host of organisms.

We demonstrated that aneuploidy can function as a novel source of genomic instability, as aneuploid cells tend to display elevated levels of mutation, mitotic recombination, and chromosome loss.

We're working to understand how aneuploidy impacts cancer progression, in hopes of developing therapies that can specifically eliminate aneuploid cancers while leaving normal cells unharmed.

Wing primordia subjected to CIN are characterised by tumor - like overgrowths, metastatic behavior and malignancy to the host upon blockade of the apoptotic machinery, and this tumorigenic response relies mainly on the production of highly aneuploid cells that delaminate from the epithelium and activate a JNK - dependent transcriptional response.

Using a series of genetically - matched euploid and aneuploid cell lines, we have demonstrated that aneuploidy can paradoxically function as a barrier to tumor growth.

Cole Laboratory publishes new paper in Cell (10/19/2017)- Chromosome mis - segregation creates cells with the wrong number of chromosomes (aneuploid cells).