Sentences with phrase «of angiogenesis»

Peter Carmeliet: «Our discovery opens up a whole new domain for inhibition of angiogenesis in various diseases such as cancer.

Inhibitors of angiogenesis seem to be safe and, unlike conventional chemotherapy, do not induce drug resistance.

E. R. Kasala et al., (2015)[3] states that «In vitro and in vivo models have shown that chrysin inhibits cancer growth through induction of apoptosis, alteration of cell cycle and inhibition of angiogenesis, invasion and metastasis without causing any toxicity and undesirable side effects to normal cells» (page 214).

One of the early pioneers of angiogenesis research, Dr. Konerding leads a group focusing on angiogenesis in inflammation, wound healing, and tumor growth, as well as on clinical anatomy.

«The potential diagnostic applications are exciting, but a great deal more work needs to be done,» says William Li, president and medical director of the Angiogenesis Foundation in Cambridge, Massachusetts.

Okyanos treatment targets the damaged heart tissue and stimulates the growth of new blood vessels through the process of angiogenesis using adult adipose -(fat) derived regenerative cells.

Vascular Cell Biology New Roles for BMP Signaling in Angiogenesis Victoria Bautch, University of North Carolina, Chapel Hill Coordination of angiogenesis by asymmetric cell division Shane Herbert, University of Manchester

Therefore, kahweol - treatment has another key target in this essential step of the angiogenesis process.

Since 2002, he has served as professor of vascular physiology at Maastricht University and professor of angiogenesis in tissue engineering at the Technical University Eindhoven.

A clinical, contemporary example of a multidisciplinary mind is Judah Folkman, the pioneer of angiogenesis research.

The classical concepts of angiogenesis consider the endothelial cells within tumors as a rather passive cell population that merely reacts in response to growth factors released by the tumor cells.

Antagonists of growth hormone releasing hormone (GHRH) given before whole body radiation lead to modulation of radiation response and organ - specific changes in the expression of angiogenesis.

Tissue - specific microvascular endothelial cell lines from H - 2K (b)- tsA58 mice for studies of angiogenesis and metastasis

The Tie receptors with their Angiopoietin ligands act as regulators of angiogenesis and vessel maturation.

As an active researcher, much of her work is focused on regulation of angiogenesis in pediatric solid tumors, including Wilms» tumor, neuroblastoma, and hepatoblastoma.

Our group is actively involved in the search for new modulators of angiogenesis from natural sources [10], [11], [12], [13], [14].

Also, it increases the rate of healing by stimulation of angiogenesis, granulation, and epithelialization, making skin grafting unnecessary and giving excellent cosmetic results.

The drug Avastin inhibits production of the angiogenesis - promoting VEGF, although oncologists must contend with other molecules in the tumor microenvironment that promote blood vessel growth.

Analysis of metastatic lymph nodes from human patients with colon or head and neck cancers also revealed no evidence of angiogenesis.

«Its involvement in the recruitment of inflammatory lymphocytes and promotion of angiogenesis may serve as a critical link between colitis and CAC.

IP5 seems a good candidate to eventually join the list of angiogenesis inhibitors already approved by the U.S. Food and Drug Administration, says cell biologist Judah Folkman of Harvard Medical School in Boston, Massachusetts.

The authors conclude that their six hallmarks — sustained proliferative signaling, evading growth suppression, resisting cell death, replicative immortality, induction of angiogenesis, and invasion / metastasis — continue to provide a useful conceptual framework for understanding the biology of cancer.

Cellular, biochemical and genetic experiments collectively establish a role of pericyte - expressed Tie2 in the control of angiogenesis and vascular maturation.

Efficacy and toxicity of the angiogenesis inhibitor SU5416 as a single agent in patients with advanced renal cell carcinoma, melanoma, and soft tissue sarcoma.

He is an expert on microvascular anatomy and patterns of angiogenesis and the effects of antiangiogenic agents in blood vessels in different organ and tissue systems.

Because the majority of angiogenesis regulatory factors appear to be sequestered in platelets, which possess the ability to selectively accumulate these factors in patients with cancer, they have the potential to detect tumor growth before it is clinically apparent.

The center is undertaking several projects, including examining colon cancer's cellular microenvironment, reversing the effects of angiogenesis and understanding how genetic changes may make colon cancer cells more aggressive in some individuals and how those changes may be reversed.

Professor Judah Folkman is the founder of the field of angiogenesis research.

His vast basic knowledge of angiogenesis, combined with his first - hand experience in clinical medicine, led to numerous breakthroughs in the field of vascular biology and provided the groundwork, and the inspiration, for other laboratories to contribute to this field.

He made and led the seminal discoveries underlying the mechanism of angiogenesis - the growth of blood capillaries - which opened a field of investigation now pursued by thousands of laboratories worldwide.

This results in cancer cells secreting large amounts of the fermentation product lactic acid into their extracellular microenvironment, lowering the extracellular pH to 6 - 6.5, contributing to acidosis, initiation of angiogenesis and providing a metabolic fuel for cancer cells, which also induces immunosuppression.

Dr Li of the Angiogenesis Foundation gave a TED talk on this in 2010.

Visionary cancer researcher Dr. William Li, founder of the Angiogenesis Foundation and a popular TED speaker, is currently in the process of creating a rating system that will score foods according to their ability to curb cancer cell angiogenesis.

Inhibition of cell proliferation and in vitro markers of angiogenesis by indole -3-carbinol, a major indole metabolite present in cruciferous vegetables.

The CAM and zebrafish in vivo assays and the ex vivo mouse aortic ring assay clearly identify kahweol as a new anti-angiogenic compound, but gives no information on which specific steps of angiogenesis are targeted by this compound.

His laboratory was the first to purify angiogenesis regulators, develop all of the assays required to study this process and propose the concept of angiogenesis - dependent diseases.

All CM members have research interests in basic cancer mechanisms, including the normal functions of oncogenes and tumor suppressor genes; regulators of cell cycle and apoptosis; regulators of angiogenesis and metastasis; and stem cells and blood formation.

Some of the proven mechanisms of action include release of endogenous opioids; stimulation of angiogenesis; reduction of the formation of fibrosis; reduction of inflammation; blockage of the effects of reactive oxygen species (ROS) release; neuronal regeneration and functional recovery; enhancement of wound closure; improvement of wound epithelialization, cellular content, granulation tissue formation, and collagen deposition; and bactericidal effects.

Promising new treatment options include novel delivery systems (inhalation or intracavitary chemotherapy); use of immunomodulators such as liposome - encapsulated muramyl tripeptide - phosphatidylethanolamine; antimetastatic agents such as inhibitors of angiogenesis (interferons, thalidomide), matrix metalloproteinase inhibitors, and minocycline; dietary modifications; and gene therapy.

For the first time, a team led by Professor Stuart Cook at Duke - NUS, uncovered a role for the gene, Wars2, in the process of angiogenesis.

They also found no increase in the levels of angiogenesis - inducing factors or in the expression of angiogenesis - related genes in metastatic lymph nodes.