Sentences with phrase «of animal exposure»

All members of the two most popular classes of lipid - lowering drugs (the fibrates and the statins) cause cancer in rodents, in some cases at levels of animal exposure close to those prescribed to humans.

Not exact matches

The transformation of animal skin into leather entails the usage of 130 various chemicals, including cyanide, and workers and people living near tanneries suffer from constant exposure to these chemicals

Under the FDA's Food Safety Modernization Act, the agency does have the authority to order the recall of certain food products when the FDA determines that there is a reasonable probability that the article of food is adulterated or in violation of certain allergen labeling requirements and that the use of or exposure to such article will cause serious adverse health consequences or death to humans or animals.

I think to succeed a photo has to be good technically — proper exposure, setting, etc. — but it also should illustrate the natural character of the animal, suggest his niche in the environment.

We tried EVERYTHING: white noise, dark room, music, no music, complete silence in the rest of the house, bath before nap, swim before naps to wear out, indirect sunlight exposure, a soft animal he could touch (only when we were watching on the monitor to avoid SIDS), etc..

A fact sheet from the US Environmental Protection Agency (EPA), indicates that about 90 % of exposure for humans is due to eating contaminated food, since dioxins and furans typically accumulate in the fatty tissues of fish and animals that are exposed when these by - products are released into the water and air during manufacturing.2 Dioxin is not metabolized in our bodies, and is passed to our children through the placenta and breastfeeding.3 Sodium Polyacrylate - Super Absorbent Polymers While actual contact with disposable diapers does not contribute to dioxin accumulation in your baby, your baby's bottom does come in contact with chemicals used to increase the absorbency of the diapers.

Studies show that dioxins collect in the fatty tissues of animals and humans, and even low levels of exposure can lead to cancer, endometriosis, birth defects, and reproductive disorders.

«Just try not to worry,» said Frederick vom Saal, whose work has shown that very low levels of exposure disrupt the hormonal system of animals.

My son hasn't had a ton of exposure to farm animals (even though we've lived in Iowa and Idaho) so I would love to do that!

For example, animal studies have demonstrated that the expression of P - glycoprotein, a broad - specificity transmembrane transporter on intestinal enterocytes, is induced by breast milk (and not formula exposure) and is protective against experimental colitis (3).

Based on the amounts being found in people and what is known about the metabolism of bisphenol A from animal experiments, it also appears that human exposures are above the current U.S. safety limit, according to the assessment.

The most recent study report described in these same regions decreased tissue levels of 5 - HT and tryptophan hydroxylase, the synthesizing enzyme for serotonin, and no evidence of excessive serotonin degradation as assessed by levels of 5 - hydroxyindoleacetic acid (the main metabolite of serotonin) or ratios of 5 - hydroxyindoleacetic acid to serotonin.30 A recent article described a significant association between a decrease in medullary 5 - HT1A receptor immunoreactivity and specific SIDS risk factors, including tobacco smoking.40 These data confirm results from earlier studies in humans39, 41 and are also consistent with studies in piglets that revealed that postnatal exposure to nicotine decreases medullary 5 - HT1A receptor immunoreactivity.42 Animal studies have revealed that serotonergic neurons located in the medullary raphe and adjacent paragigantocellularis lateralis play important roles in many autonomic functions including the control of respiration, blood pressure, heart rate, thermoregulation, sleep and arousal, and upper airway patency.

In animal models, exposure to cigarette smoke or nicotine during fetal development alters the expression of the nicotinic acetylcholine receptor in areas of the brainstem important for autonomic function, 28 alters the neuronal excitability of neurons in the nucleus tractus solitarius (a brainstem region important for sensory integration), 29 and alters fetal autonomic activity and medullary neurotransmitter receptors.30 In human infants, there are strong associations between nicotinic acetylcholine receptor and serotonin receptors in the brainstem during development.31 Prenatal exposure to tobacco smoke attenuates recovery from hypoxia in preterm infants, 32 decreases heart rate variability in preterm33 and term34 infants, and abolishes the normal relationship between heart rate and gestational age at birth.33 Moreover, infants of smoking mothers exhibit impaired arousal patterns to trigeminal stimulation in proportion to urinary cotinine levels.35 It is important to note also that prenatal exposure to tobacco smoke alters the normal programming of cardiovascular reflexes such that there is a greater - than - expected increase in blood pressure and heart rate in response to breathing 4 % carbon dioxide or a 60 ° head - up tilt.36 These changes in autonomic function, arousal, and cardiovascular reflexes might all increase an infant's vulnerability to SIDS.

In the past, Suffolk County officials have been reluctant to indemnify other nonprofit groups with contracts, such as the Society for Prevention of Cruelty to Animals, because of the potential exposure to damages in a lawsuit.

As a result, the Oneida County Health Department is cautioning area residents to be particularly prudent when dealing with animals, both domestic and feral in order to reduce the risk of exposure to the deadly virus transmitted through the saliva and mucous membranes of an infected animal.

Rabies is caused by a virus that people and other mammals can get through exposure to the saliva or nervous tissue of a rabid animal and is fatal without proper «Post Exposure Prophylaxis («PEP») vexposure to the saliva or nervous tissue of a rabid animal and is fatal without proper «Post Exposure Prophylaxis («PEP») vExposure Prophylaxis («PEP») vaccines.

Over the past 5 years, a few promising candidate drugs designed to ward off the effects of radiation exposure have begun to undergo animal, and even human, testing.

«We know noise exposure has an effect on male fertility in animals, but our study is the first to show the risk of exposure to environmental noise on male infertility in humans.»

Heat - not - burn devices may eliminate users» exposure to tobacco smoke, but the vapor they produce has the same negative impact on blood vessel function as smoking, according to a preliminary animal study presented at the American Heart Association's Scientific Sessions 2017, a premier global exchange of the latest advances in cardiovascular science for researchers and clinicians.

In most animals, exposure to acid stimulates special channels at the tips of sensory neurons called nociceptors.

Aversive associative learning in Aplysia california survives restraint of the animal and surgical exposure of the central nervous system.

Researchers performed a meta - analysis of literature examining patients with NASH, and then tested their hypothesis using an animal model, which enabled them to eliminate possible confounders of the clinical data, such as antibiotic exposure and medical comorbidities.

The stress groups were compared to a fourth group of animals that served as controls, with no exposure to stress or acupuncture.

Likewise, instead of researching how alcohol exposure affected the developing rat fetus, I daydreamed about a career that didn't involve microscopes, animal colonies, or behavioral testing.

To discover this, Hui Liu, Gene Robinson, and Eric Jakobsson of the University of Illinois developed new computational tools to analyze patterns of gene conservation across a wide range of animals, for genes activated and inhibited in the honey bee brain by exposure to a chemical communication signal that triggers alarm.

After exposure to the pollution for five hours per day, three days a week for 10 weeks, the animals showed accelerated aging in the hippocampus, a region of the brain associated with memory.

The NRC panel, chaired by neurobiologist Charles Stevens of the Salk Institute in La Jolla, California, looked at more than 500 human, animal, and cellular studies on EMFs and found «no conclusive and consistent evidence... that exposures to residential electric and magnetic fields produce cancer, adverse neurobehavioral effects, or reproductive and developmental effects.

The researchers announced results from human and animal studies that found biomarkers of harmful cardiac, pulmonary, and reproductive effects from exposure to alternative tobacco products — a growing market of constantly evolving products including electronic cigarettes, hookah, and smokeless tobacco like snuff and gutkha.

«More worryingly, since low - level chemical exposure poses a threat to human reproductive development, the consumption of products from animals grazing such pastures may be of considerable environmental concern.»

Only one of the 20 Spalax tested (an animal that was more than 10 years old) developed malignant tumors after exposure to one of the carcinogens.

Studies with lab animals have linked pyrethroid exposure to damage of the thyroid, liver and nervous system, as well as impairment of behavioral development, changes in the immune system and disruption of reproductive hormones, according to the 2006 EPA review.

He remains very concerned about the exposure of animals that inhabit the depths and migrate upwards at night to feed, as well as animals at the sea floor.

This is having a major effect on the allocation of research funding, the use of animal testing and the exposure of patients to non-active substances.

protected animals»); studies on in vitro systems (whole perfused organs, tissue slices, cell and tissue cultures, and subcellular fractions); and human studies (including estimations of occupational and environmental exposure, postmarketing surveillance, epidemiology, and the ethical and strictly controlled use of human volunteers).

In a similar way, we and other groups have early data that exposure of rats and mice to high levels of social stress can make the offspring of those animals more susceptible to social stress, again something that persists for several generations.

In tests in mice, animals that received a single dose of one of the vaccines showed no symptoms following exposure to the real pathogen — Ebola, H1N1 influenza, or Toxoplasma gondii.

The researchers collected information on exposure to animal skin during the first three months of life, along with information on the health of children until the age of 10 years.

All three of the exposed animals not only survived the virus but developed high amounts of protective antibodies against it, likely protecting them against future exposures (although the research team has not yet explored how long that immunity lasts).

None of the 10 people had worked on farms or had direct exposure to food animals.

Two - thirds of the animals were protected when treated 48 hours after exposure.

Researchers used both animal models and human cells to demonstrate the hyper - responsiveness of MAIT cells to systemic exposure to bacterial superantigens.

Led by Bavari and Travis Warren, Ph.D., the USAMRIID team performed a series of studies involving a lethal challenge with Marburg virus in nonhuman primates to determine the efficacious dose and regimen of AVI - 7288, as well as to characterize the drug exposures in animals that produced efficacy.

Principle investigator Shuk - mei Ho, PhD, director of the Cincinnati Cancer Center, Jacob G. Schmidlapp Chair of Environmental Health and professor at the University of Cincinnati College of Medicine, says that human exposure to BPA is a common occurrence and that animal studies have shown that BPA contributes to development of prostate cancer but that human data are scarce.

However, none of the supplements worked very well in animals, even when researchers administered them in repeated, high doses for a month prior to a noise - exposure test, Le Prell notes.

After three years of exposure to one of two powerful carcinogens, only one of the 20 animals studied developed any tumours.

«Although the doses of EDCs were somewhat high, we did this to simulate their effects of daily exposure, as well as body accumulation due to long - term exposure, simultaneously in animal experiments,» said Choi.

Higher - impact committees have more prestige but arguably more exposure: search committees for the recruitment of new faculty members, personnel committees for tenure and promotion, or institutional review boards (IRBs) for the enforcement of regulations and the approval of plans for human - subjects and animal research.

«We have animal literature, which shows direct links between exposure and adverse health outcomes, the limited human studies, and the fact that 90 to 100 percent of the population has measurable levels of these compounds in their bodies,» said John Meeker, an assistant professor of environmental health sciences at the University of Michigan School of Public Health and a lead author.

By analyzing the chemical composition of the water in which the animals lived during the duration of the experiment, the researchers determined that exposure to space induces distinct differences in metabolism and / or secretion.

One of his latest studies, published in 2015, found that exposure to bright blue - white light during the day has the opposite effect of light exposure at night: It greatly enhances the release of melatonin and inhibits the proliferation of prostate cancer cells in an animal model.