There are also many other differences in the number or coding sequences
of ankyrin repeat genes between wMel strain genomes and wAu [21], [49](see also [15] and [48] for sequence of wMelCS).
To see what was happening in the brains
of these ankyrin - G mutant mice, the researchers analyzed the cell components in inhibitory synapses connecting with pyramidal neurons, finding that two proteins known as GAT1 and GAD67 — responsible for making the neurochemical GABA that dials back nerve impulses — were at much lower levels in the synapses on pyramidal neurons in ankyrin - G mutant mice than in normal mice.
In collaboration with Dr. Ke Xu's lab at UC Berkeley, the team determined that this is because of aberrant accumulation and distribution
of Ankyrin - G in the AIS.
Not exact matches
The sequence similarity between MAD - 3 and pp40 includes a casein kinase II and consensus tyrosine phosphorylation site, as well as five repeats
of a sequence found in the human erythrocyte protein
ankyrin.
In baseline tests, the high - energy
ankyrin - G mice usually swam longer, only floating for about 10 seconds
of the 200 second test compared to the normal mice that floated about 50 seconds, but after several sessions with the bully mice, the
ankyrin - G mice were quick to give up and float, remaining still for well over 100 seconds on average.
The research group hopes to use its
ankyrin - G mice to better understand the biology
of bipolar disorder, to help clarify how lithium works to treat bipolar disorder, and to test new treatments for bipolar disorder.
Specifically, the mice lacked the protein
ankyrin - G, in particular neurons in the brain, a defect that appears to make the animals both hyperactive and less fearful, a behavioral profile suggestive
of a mania - like state for a mouse.
Molecular mechanisms that enhance synapse stability despite persistent disruption
of the spectrin /
ankyrin / microtubule cytoskeleton.
Here we show variation between incompatible Culex strains in two Wolbachia
ankyrin repeat - encoding genes associated with a prophage region, one
of which is sex - specifically expressed in some strains, and also a direct effect
of the host nuclear genome on CI rescue.
I became an eye researcher completely by accident while trying to unravel the role
of a protein called
Ankyrin in forming biological important membrane domains in cells, in this case, the photoreceptor.