Agre shared the Nobel Prize in Chemistry with Roderick MacKinnon in 2003 for his discovery
of aquaporins — channels that regulate and facilitate water molecule transport through cell membranes, a process essential to all living organisms.
Shapiro's team realized that increasing the number
of aquaporins on a given cell made it stand out in MRI images acquired using a common clinical technique called diffusion - weighted imaging, which is sensitive to the movement of water molecules.
And the work of Landon King, who is the director of the pulmonary and critical care medicine program at Johns Hopkins now; when Landon was a fellow in our laboratory, he discovered that in fact glucocorticoids, corticosteroids induce regulation expression
of the aquaporins in the microvasculature of the lung.
«Dr Burton's work is groundbreaking because it clarifies the roles
of aquaporins in the brain during the short and long - term responses to traumatic head injury.
Laminar - specific and developmental expression
of aquaporin - 4 in the mouse hippocampus.
Functional Expression
of Aquaporin - 2 Tagged with Photoconvertible Fluorescent Protein in mpkCCD Cells.
Specialized membrane domains for water transport in glial cells: high - resolution immunogold cytochemistry
of aquaporin - 4 in rat brain.
Enhanced expression
of aquaporin 4 in human brain with inflammatory diseases.
Roles
of aquaporin 4 and Kir4.1 in brain water and potassium homeostasis: lessons from knockout mice
«Overexpression
of aquaporin has no negative impact on cells because it is exclusive to water and simply allows the molecules to go back and forth across the cell membrane,» Shapiro says.
Nadia Nabil Haj - Yasein Roles
of aquaporin 4 and Kir4.1 in brain water and potassium homeostasis: lessons from knockout mice Faculty of Medicine, University of Oslo, 28 February 2012 Supervisor: Erlend Arnulf Nagelhus
Not exact matches
The gene
aquaporin - 1 encodes channel - forming integral protein (CHIP), a member
of a large family
of water transporters found throughout nature.
It has been understood for several years that, in patients suffering from this disease, immune cells attack the
aquaporin - 4 water channel
of the brain cells.
For example, the
aquaporin protein - mediated flow
of water across biological cell membranes is down to a balance between hydrophobic and hydrophilic interactions with channel surfaces.
This work builds on more than a decade
of research conducted by the University
of Adelaide's Professor Andrea Yool on the water channel proteins known as «
aquaporins.»
Aquaporins have long been known to act as pores by transporting water across membranes in plants and animals, and they play critical roles in controlling the water content
of cells.
This particular
aquaporin is abundant on the surface
of roots.
There is efforts now to block the reabsorption
of water through
aquaporin biology, but we're still not there yet.
So we went after this, and now
of course that protein is known as
aquaporin 1, the first defined water channel; a large family
of hundreds
of different water channels and different organisms — these green plants around us here have
aquaporins in their rootlets.
Decreased expression
of the glial water channel
aquaporin - 4 in the intrahippocampal kainic acid model
of epileptogenesis.
Aquaporin sits within the membrane that envelops cells and acts as a gatekeeper for water molecules, allowing them to move in and out
of the cell.
This means that when a gene
of interest is turned on, the cell will overexpress
aquaporin, making the cell look darker under diffusion - weighted MRI.
Structural biology
of eukaryotic
aquaporins Thursday 20 May 2010 at 1415 Small auditorium, Domus Medica, University
of Oslo
Under normal physiological conditions the number
of water molecules entering and exiting an
aquaporin - expressing cell is the same, so that the total amount
of water in each cell does not change.
Multiplex QPCR reactions
of RT product were performed using FAM - labeled probes for
aquaporin 4, S100b, CX43, GLT - 1 and AKAP12, in combination with VIC - labeled, primer limited GAPDH probe and Taqman mastermix (all Applied Biosystems).
To continue this work, he moved to the Walz lab as a post-doctoral fellow, where he completed the first atomic resolution structure
of a mammalian membrane protein,
aquaporin - 0, using electron microscopy.
In 2012, he showed that interfering with phosphorylation
of the membrane protein
aquaporin - 0 results in cataracts that are visually the same as those in a human patient.
Picture of the day:
It seems like Nobel Laureate Peter Agre ’ s lecture on “ Aquaporin Water Channels ” was not only educational and informative but also made the young scientists laugh.
But research supports the use
of ceramides and
aquaporins in moisturizers.
Rheinanthrone, a metabolite
of sennoside A, triggers macrophage activation to decrease
aquaporin - 3 expression in the colon, causing the laxative effect
of rhubarb extract.
Some
of the companies working on incorporating biomimicry into design are: Calera (biomineralization) Novomer (CO2 into biodegradable plastics) Dyesol (solar cells) Qualcomm (display screens) WhalePower (wind turbines) BioPower (wave power) Purebond (bonding systems) Regen Energy (energy solutions) Qinetiq (water harvesting) Grimshaw (architecture)
Aquaporin (water purification) PAXwater (flow forms) Cambridge Biostability (preservation) Biosignal (antibacterial methods) The Land Institute (agriculture systems)