Insights into substrate specificity of geranylgeranyl reductases revealed by the structure of digeranylgeranylglycerophospholipid reductase, an essential enzyme in the biosynthesis
of archaeal membrane lipids.
The researchers compared the sequence to that of other sequenced methanogens to identify a distinct set of genes characteristic
of archaeal methanogens.
Comparison
of archaeal and bacterial genomes: computer analysis of protein sequences predicts novel functions and suggests a chimeric origin for the archaea.
As a follow - up, which is the current study, they tested 51 volunteers and decided to get a large range in ages to test the age - dependency
of the archaeal signatures.
«If we could turn back the clock and peer inside this cell, would its cellular organization have been like
that of an archaeal cell or more eukaryote - like?»
Recent findings emphasize the importance of investigating members
of the archaeal domain of life in order to obtain a more comprehensive view of microbial ecology, symbiosis, and metabolic interdependencies involving archaeal partners, and of evolution of life on Earth in regard to the deep roots of archaea as well as our microbial ancestry.
In this Review, we provide an overview of the currently recognized archaeal diversity, summarize new findings on the metabolic potential of recently described archaeal lineages, and discuss these data in light
of archaeal evolution.
Not exact matches
The mix
of nuclear genes would come from the
archaeal guest and later from the mitochondrion, which forfeited parts
of its genome to the nucleus over time.
Hartman suggested in 1984 that the nucleus arose when a hypothetical cell that stored its genetic information as RNA instead
of DNA and possessed a simple cytoskeleton became the host for an
archaeal organism.
Recently discovered
archaeal lineages include mesophiles and (hyper --RRB- thermophiles, anaerobes and aerobes, autotrophs and heterotrophs, a large diversity
of putative
archaeal symbionts, as well as previously unknown acetogens and different groups
of methanogens (see the figure).
Spang et al. review the diversity
of Archaea and their genomes, metabolomes, and history, which clarifies the biology and placement
of recently discovered
archaeal lineages.
Excitingly, these proteins are functionally enriched for membrane bending, vesicular biogenesis, and trafficking activities, suggesting that eukaryotes evolved from an
archaeal host that contained some key components that governed the emergence
of eukaryotic cellular complexity after endosymbiosis.
On the basis
of our current understanding, much
archaeal diversity still defies genomic exploration.
Recently, cultivation - independent sequencing methods have produced a wealth
of genomic data for previously unidentified
archaeal lineages, several
of which appear to represent newly revealed branches in the tree
of life.
The lineages
of these groups are not restricted to extreme habitats, as was once thought common for
archaeal species; rather, archaea are widespread and occur in all thinkable environments on Earth, where they can make up substantial portions
of the microbial biomass.
Efforts to obtain and study genomes and enrichment cultures
of uncultivated microbial lineages will likely further expand our knowledge about
archaeal phylogenetic and metabolic diversity and their cell biology and ecological function.
The authors consider the available data to explore an essential question: what might the
archaeal ancestor
of all eukaryotes look like?
Orphan and her team plan to use the genomic information from the paired methane - oxidizing
archaeal and bacterial partners to develop deeper insights into the physiology and mechanisms
of interaction and energetic exchange between different methanotrophic consortia coexisting in the environment.
Using heavy - duty computers to sift through this mess, the team ultimately reconstructed 7280 bacterial and 623
archaeal genomes — about a third
of which were new to science.
«From a practical standpoint, the ability to direct the specific, addressable destruction
of DNA... could have considerable functional utility, especially if the system can function outside
of its native bacterial or
archaeal context,» they wrote.
Currently only 35 bacterial and
archaeal phyla are recognized on the basis
of classical approaches to microbial taxonomy.
Ten years ago in the early days
of genome sequencing, researchers scoured the genomes
of 580 bacterial and
archaeal species for large genes.
Currently, we are exploring several environmental samples retrieved from allover the world - ranging from hydrothermal vents in Japan to hot springs in Yellowstone National Park and New Zealand — for the presence
of novel
archaeal (and bacterial) lineages using cultivation - independent approaches, such as metagenomics and single cell genomics.
One
of the main findings that we have obtained thus far, is that the eukaryotic lineage seem to branch from within the
archaeal Domain
of life, affiliating with the so - called «TACK» superphylum (comprising Thaum -, Aig -, Cren - and Korarchaeota).
Disa will work on the genomic exploration
of «microbial dark matter», focusing on new
archaeal lineages and viruses, using both lab - and bioionformatics - based approaches.
This study sheds new light onto
archaeal genome evolution, the deep roots
of archaea and the phylogenetic placement
of DPANN.
Now available in the Early Edition
of PNAS: Tom Williams (University
of Bristol, UK) in collaboration with, among others, the Ettema - lab reports on using integrative modeling
of gene and genome evolution to root the
archaeal tree
of life and to resolve the metabolism
of the earliest
archaeal cells.
Starting his first postdoc here in Ettema - lab his work will involve the exploration
of poorly described
archaeal lineages and the development
of novel methods to investigate syntrophic relationships in microbial communities.
The genome
of M. acetivorans C2A is by far the largest
of all sequenced
archaeal genomes.
«
Archaeal Dominance in the Mesopelagic Zone
of the Pacific Ocean.»
Tom Williams (University
of Bristol, UK) in collaboration with, among others, the Ettema - lab reports on using integrative modeling
of gene and genome evolution to root the
archaeal tree
of life and to resolve the metabolism
of the earliest
archaeal cells.
To gain a better understanding
of the evolutionary path by which these
archaeal proteins gave rise to the eukaryotic cytoskeleton we have assembled a team
of global experts in cytoskeletal biology and evolutionary cell biology.
Of special interest is the
archaeal Domain, which remains poorly chraracterized to date.
Using second and third generation sequencing technologies, we aim at generating genomic data
of novel bacterial and
archaeal lineages, as well as
of unchracterized protists.
Comparisons
of bacterial and
Archaeal Communities in the Rumen and a Dual - Flow Continuous Culture Fermentation System using Amplicon Sequencing — I J Salfer — Journal
of Animal Science
Impact
of Different Bioenergy Crops on N - Cycling Bacterial and
Archaeal Communities in Soil, Yuejian Mao, Anthony Yannarell, Sarah Davis, Roderick I. Mackie, Environmental Microbiology, doi: 10.1111j.1462-2920.2012.02844.x, August 2012.
Recently, this very lab described the Asgard Archaea, an
archaeal phylum with clear signs
of cellular complexity, such as the presence
of eukaryotic membrane trafficking components.
All but three
of the 65
archaeal sequences appeared to be from methanogenic microbes.
Starting his first postdoc here in Ettema - lab his work will involve the exploration
of poorly described
archaeal lineages and
By utilizing metagenomic data from newly discovered bacterial and
archaeal groups, we are able to perform exploratory evolutionary analyses and test specific hypothesis regarding the origins
of various systems.
My research is framed within the Wellcome Trust consortium on the
archaeal origins
of eukaryotic cell organization (http://evocyt.com/), which includes a diverse group
of researchers studying the evolution
of eukaryotic machinery from different points
of view — e.g. how do specific cellular systems work in different lineages, and how did that affect the origin
of the eukaryotic cell plan?
Finally, there is no attempt to see if their analysis (
of the degree
of cyclization
of aquatic
archaeal glycerol dialkyl glycerol) might be affected by modern changes in the lake.
What do those do to the degree
of cyclization
of aquatic
archaeal glycerol dialkyl glycerol?
I note that in their SOI they list the constants used with the magical formula that relates the temperature to the degree
of cyclization
of aquatic
archaeal glycerol dialkyl glycerol tetraethers to temperature... as they say...