The cooperative function
of arginine residues in the Prototype Foamy Virus Gag C - terminus mediates viral and cellular RNA encapsidation.
These compounds include some features of the polyethylene - hexamethylene biguanide NB325, as well as the peptide T140 that has five guanide groups on the side chains
of arginine residues.
Not exact matches
One unique characteristic
of ATAs is that they recognize two different substrates in the same active site, and it was found that the active - site
residue arginine (Arg138) functions on both substrates.
For example, the replacement
of an Arg
residue with the epimeric N - methyl - D -
arginine led to the identification
of the cyclic pentapeptide - based CXCR4 antagonist FC122 (4) that shows a significant enhancement
of CXCR4 antagonistic activity (Figure 5)[11, 66, 69, 70].
The simplest structure
of glucosepane is a lysine
residue linked to a
arginine residue by a degraded form
of glucose (which has turned into the imadazolium ring, etc).
However, we also detected a G to A mutation at chr15: 88432938 (one base downstream) affecting the same
arginine residue but changing it to tryptophan (R140W) instead
of leucine.
This occurrence could have hindered the detection
of junction - spanning peptides, since most mass spectrometry experiments involve digesting proteins with the enzyme trypsin, which cuts peptide chains exclusively after
arginine and lysine
residues.
HMT family
of proteins consist
of enzymes that methylate lysine or
arginine residues on histone tails as well as other proteins.