Sentences with phrase «of aristolochic acids»

Many traditional pharmacopeias include Aristolochia and related plants, which contain nephrotoxins and mutagens in the form of aristolochic acids and similar compounds (collectively, AA).

Mutational signatures reveal high burdens of aristolochic acid — related mutations in Asian liver cancers, with Taiwan most intensely affected.

Not exact matches

At least one of the four medicines that contained Aristolochia DNA also contained aristolochic acid.

Genomic sequencing experts at Johns Hopkins partnered with pharmacologists at Stony Brook University to reveal a striking mutational signature of upper urinary tract cancers caused by aristolochic acid, a plant compound contained in herbal remedies used for thousands of years to treat a variety of ailments such as arthritis, gout and inflammation.

«Genome - wide sequencing has allowed us to tie aristolochic acid exposure directly to an individual getting cancer,» Kenneth Kinzler, Ph.D., professor of oncology in the Johns Hopkins Kimmel Cancer Center's Ludwig Center for Cancer Genetics and Therapeutics.

But the genome - wide spectrum of mutations associated with aristolochic acid exposure remained largely unknown.

Dr. Donald M. Marcus, professor emeritus of medicine and immunology at Baylor, and Dr. Arthur P. Grollman, distinguished professor of pharmacological sciences at Stony Brook University, discuss the scientific evidence showing that the plant Aristolochia can cause aristolochic acid nephropathy (AAN).

When a member of Rozen's team spotted the same type of mutation in liver cancer, the group wondered if plants that contain aristolochic acid might increase a person's risk of developing the disease.

«I was dumbstruck to find the evidence of exposure to aristolochic acid in 78 per cent of cases,» says Rozen.