This is because as bodyfat goes up so do
levels of the aromatase enzyme and this means that the rate at which men start producing estrogen goes up.
These studies demonstrate that chrysin is a more potent inhibitor
of the aromatase enzyme than phyto - estrogens and other flavonoids that are known to have aromatase - inhibiting properties (Arch Pharm Res 1999 Jun; 22 (3): 309 - 12; J Steroid Biochem Mol Biol 1997 Apr; 61 (3 - 6): 107 - 15).
However in cases where low testosterone levels are not related to excessive aromatisation the
use of aromatase inhibitors on their own are of little benefit.
Without adequate amounts of zinc, the testicular cells lose the ability to convert lipids, concentration of androgen receptors decrease and levels
of aromatase in the liver are inhibited.
A researcher at Syracuse University has simple advice for breast cancer survivors struggling with the side
effects of Aromatase Inhibitors (AIs): exercise.
Estrogen is usually thought of as a female hormone but it is also found in men and converts from testosterone via the
action of the aromatase enzyme.
In summary, this study sheds light on the somatic alteration landscape of ER - positive breast cancers and offers insight into some of the
mechanisms of aromatase inhibitor resistance.
This month, Matthew J. Ellis and colleagues reported the whole - genome and / or exome sequencing of 77 estrogen - receptor - positive (ER +) breast cancer patients enrolled in a clinical
trial of aromatase inhibitors.
A multi-center randomized trial was conducted to determine if acupuncture would be effective in relieving pain as a
result of aromatase inhibitors, a commonly used treatment for breast cancers that are hormone sensitive.
Also, I have since found out, based on literature review, that I have a high
intake of aromatase inhibitors, many plant foods.
The citrus flavonone hesperetin inhibits
growth of aromatase - expressing MCF - 7 tumor in ovariectomized athymic mice.
Declining testosterone in aging males can be the result of several factors one of these being an
excess of the aromatase enzyme activity resulting with too much testosterone being aromatised into estrogen.
When there is a high level
of aromatase present in the male body, too much testosterone will be converted to estrogen.
In hypothyroidism, both the increased
amount of aromatase and the increased activity of the enzyme largely contribute to the problem of excessive estrogen.
I have had so many people comment on how strong and full my hair looks, and this at a time when I was extremely worried about hair thinking and potential hair loss as a result of starting on a five year
programme of aromatase inhibitors.
Although supplements purported to increase testosterone have been around for awhile, recently we have seen the introduction of novel new nutrients which are research proven to increase testosterone levels such as various
forms of aromatase inhibitors such as pZole seen in the supplement Triazole, which reduces estrogen and causes a rise in testosterone, as well as D - Aspartic Acid (Testforce 2) and those based around the Prolensis herb (Tropinol).
As aromatase inhibition is dose - dependent, it has been suggested that aromatase is less suppressed in the testes than in adipose and muscle tissue, which explains the incomplete
effectiveness of aromatase inhibition in men.
Estrogen is often overproduced in hypothyroidism by increased
production of aromatase, which converts testosterone and other androgens into estrogen.
Dear Dr. Gregor, what nutrients do you recommend to counteract the side
effects of aromatase inhibitors, and is there any diet which could eliminate the need for them at all?
Adrenal fatigue, which is a disorder that affects the adrenal glands, may also cause the level
of aromatase in the body to increase *; thus leading to high estrogen levels and low testosterone levels.
In these cases where an excess of aromatisation exists the use
of an aromatase inhibitor can help obtain a healthy estrogen: testosterone balance.
Another natural inhibitor
of aromatase is chrysin.
Stress also increases the production
of aromatase and 5 - alpha - reductase, two enzymes that break down testosterone.
Resveratrol — a natural inhibitor
of aromatase.
As men age, their levels
of aromatase increase, thereby depleting free testosterone and increasing estrogen levels.
6 OXO is a suicide inhibitor
of aromatase, and when it binds to aromatase, the binding is irreversible [1].
Estrogen production in endometriosis and use
of aromatase inhibitors to treat endometriosis
Chrysin - may limit the activity
of aromatase, resulting in lower estrogen levels and increased testosterone levels.
They can help decrease the activity
of aromatase and therefore lower the production of estrogen in men.
When we gain more fat cells, we will have higher levels
of aromatase.
As a result, people with more fat cells in their bodies, have high levels
of aromatase and higher levels of estrogen.