We are also studying the mechanisms
of asymmetric cell division.
The First Cell Cycle of the Caenorhabditis elegans Embryo: Spatial and Temporal Control
of an Asymmetric Cell Division.
For his postdoc, he joined the laboratory of Lily and Yuh Nung Jan at University of California San Francisco to analyse the mechanisms
of asymmetric cell division.
This is the first time to visualize the real time event
of asymmetric cell division, and we were able to see other events such as cell elongation of the zygote and migration of the nucleus.»
«Live cell imaging
of asymmetric cell division in fertilized plant cells: Insight into why leaves grow up and roots grow down in flowering plants.»
Not exact matches
Through their studies, they observed that zygotes absent
of SSP, WRKY2, and HDG11 / 12, do not develop properly and their
cell division no longer becomes
asymmetric.
Ueda's group also discovered HOMEODOMAIN GLABROUS11 (HDG11) and HDG12, the factors derived from the egg
cells, which are responsible for controlling the
asymmetric division of the zygote and development
of the embryo.
This
asymmetric cell division leads to small and large
cells on the top and bottom part
of the embryo, respectively.
This
division has to be «
asymmetric,» meaning that only one
of the two
cells generated during the stem
cell division goes on to differentiate, while the other
cell remains a stem
cell.
After a certain period, some
of these stem
cells switch to producing neurons, a stage known as
asymmetric division.
«Neural stem
cell divisions appear to be much more
asymmetric than we had previously anticipated,» states Darcie Moore, postdoc in the group
of Sebastian Jessberger and lead author
of the study.
Not only did the group succeed in visualizing the real time events
of zygote polarization and
asymmetric cell division, they were able to quantify the dynamic patterns
of the cytoskeleton (i.e. formation
of the ring structure and longitudinal array
of MTs and F - actin, respectively).
The group succeeded in visualizing for the first time, how the cytoskeleton
of plant egg
cells is disassembled after fertilization and then reorganized to create a polarity in the
cell that eventually leads to
asymmetric cell division.
«Although polarization and
asymmetric cell division of zygotes to form the body axis is a common phenomena found in algae, mosses, and flowering plants, the origin
of cell polarity and how
asymmetric cell division occurs have remained a mystery up to now,» says Dr. Minako Ueda, a lecturer at ITbM, Nagoya University and a leader
of this research.
«We were able to show by live
cell imaging that polarization
of the
cell occurs after fertilization
of the egg
cell, and both MTs and F - actin play a role in inducing
asymmetric cell division to form the plant's body axis,» says Ueda.
In order to investigate their specific roles, they used inhibitors
of each protein to see their effect on zygote polarization and
asymmetric cell division.
The group's results show that MTs are responsible for elongation
of the zygote along the top - bottom axis, whereas F - actin plays a role in moving the nucleus towards the top part
of the zygote, to make it ready for
asymmetric cell division.
Ana Fonseca (Corbeil, TUD)-- «New insights into
cell migration and
asymmetric cell division of human hematopoietic progenitors» (2008)
In parallel, the roles
of symmetric and
asymmetric cell divisions are investigated as a mechanism for governing stem
cell self - renewal and differentiation during embryonic development and in the adult.
Jürgen Knoblich Institute
of Molecular Biotechnology
Asymmetric cell division and proliferation control in Drosophila
[email protected] +43 1790 44 4800
Abstract We discovered that a subset
of satellite
cells in skeletal muscle are self - renewing stem
cells that give rise to myogenic progenitors through
asymmetric apical - basal
cell divisions.
Importantly, this results in an abnormal increase in centrosome number, a 10-fold reduction in the numbers
of satellite stem
cells undergoing
asymmetric divisions, and a marked decrease in the generation
of myogenin - expressing progenitors.
Accordingly, our data suggests that the failure
of regenerative myogenesis to keep pace with disease progression in DMD is not due to muscle stem
cell exhaustion, but rather is due to a
cell - autonomous deficiency in
asymmetric division.
«
Asymmetric cell division is the gold standard feature
of normal stem
cells,» Tang said.
Vascular
Cell Biology New Roles for BMP Signaling in Angiogenesis Victoria Bautch, University of North Carolina, Chapel Hill Coordination of angiogenesis by asymmetric cell division Shane Herbert, University of Manche
Cell Biology New Roles for BMP Signaling in Angiogenesis Victoria Bautch, University
of North Carolina, Chapel Hill Coordination
of angiogenesis by
asymmetric cell division Shane Herbert, University of Manche
cell division Shane Herbert, University
of Manchester
This
division can be oriented, daughter
cells can be pushed inside or outside as result
of the mitotic spindle orientation, and
asymmetric, daughter
cells can acquire distinct components giving them different contractile properties.
16 -
cell stage doublet resulting from the
asymmetric division of an isolated 8 -
cell stage blastomere.
The first talk
of the meeting was by Juergen Knoblich, and it was great to hear about his current projects, using Drosophila genetics to understand
cell cycle exit and quiescence plus the contribution
of changing the balance
of asymmetric versus symmetric
divisions in development
of various disorders.
Furthermore,
cells in which MELK had been depleted displayed
asymmetric division (Figure 6G), characterized by an unequal allocation
of cell mass into daughter
cells.